Basic Information:

  VIRBase ID:  

VHID00374726

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          PTPN6:  NM_080549     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	PTPN6
miRBase Accession/Entrez ID	MIMAT0003717	5777
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCP//HCPH//HPTP1C//PTP-1C//SH-PTP1//SHP-1//SHP-1L//SHP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PTPN6	chr12:7057613(+) A-I      intronic chr12:7057600(+) A-I      intronic chr12:7057568(+) A-I      intronic chr12:7057399(+) A-I      intronic chr12:7059145(+) A-I      intronic chr12:7057892(+) A-I      intronic chr12:7057884(+) A-I      intronic chr12:7056765(+) A-I      intronic chr12:7056583(+) A-I      intronic chr12:7057875(+) A-I      intronic chr12:7057217(+) A-I      intronic chr12:7057906(+) A-I      intronic chr12:7057849(+) A-I      intronic chr12:7057848(+) A-I      intronic chr12:7057380(+) A-I      intronic chr12:7057980(+) A-I      intronic chr12:7057210(+) A-I      intronic chr12:7058058(+) A-I      intronic chr12:7056678(+) A-I      intronic chr12:7058004(+) A-I      intronic chr12:7059038(+) A-I      intronic chr12:7057581(+) A-I      intronic chr12:7057841(+) A-I      intronic chr12:7056571(+) A-I      intronic chr12:7056651(+) A-I      intronic chr12:7058060(+) A-I      intronic chr12:7056685(+) A-I      intronic chr12:7057372(+) A-I      intronic chr12:7056734(+) A-I      intronic chr12:7056682(+) A-I      intronic chr12:7057925(+) A-I      intronic chr12:7057960(+) A-I      intronic chr12:7058000(+) A-I      intronic chr12:7057247(+) A-I      intronic chr12:7057997(+) A-I      intronic chr12:7057379(+) A-I      intronic chr12:7057585(+) A-I      intronic chr12:7057185(+) A-I      intronic chr12:7057514(+) A-I      intronic chr12:7060331(+) A-I      intronic chr12:7057924(+) A-I      intronic chr12:7059008(+) A-I      intronic chr12:7057488(+) A-I      intronic chr12:7059084(+) A-I      intronic chr12:7056677(+) A-I      intronic chr12:7056733(+) A-I      intronic chr12:7057462(+) A-I      intronic chr12:7056561(+) A-I      intronic chr12:7057519(+) A-I      intronic chr12:7056569(+) A-I      intronic chr12:7057926(+) A-I      intronic chr12:7057224(+) A-I      intronic chr12:7057495(+) A-I      intronic chr12:7057267(+) A-I      intronic chr12:7056739(+) A-I      intronic chr12:7058053(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PTPN6	chr12:7056682(+) A-I intron -    22327324 chr12:7056685(+) A-I intron -    22327324 chr12:7056733(+) A-I intron -    22327324 chr12:7056571(+) A-G intron -    22484847 chr12:7056651(+) A-G intron -    22484847 chr12:7056677(+) A-G intron -    22484847 chr12:7056678(+) A-G intron -    22484847 chr12:7056682(+) A-G intron -    22484847 chr12:7056685(+) A-G intron -    22484847 chr12:7056733(+) A-G intron -    22484847 chr12:7056739(+) A-G intron -    22484847 chr12:7056851(+) G-A intron -    22484847 chr12:7057267(+) A-G intron -    22484847 chr12:7057462(+) A-G intron -    22484847 chr12:7057514(+) A-G intron -    22484847 chr12:7058000(+) A-G intron -    22484847 chr12:7058053(+) A-G intron -    22484847 chr12:7058060(+) A-G intron -    22484847 chr12:7056569(+) A-G intron -    22484847 chr12:7057997(+) A-G intron -    22484847 chr12:7059008(+) A-G intron -    22484847 chr12:7059038(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTPN6	chr12:7055707-7055708(+) m6A 5'UTR       24981863 chr12:7060538-7060539(+) m6A 5'UTR//exon//intron       - chr12:7060544-7060545(+) m6A 5'UTR//exon//intron       - chr12:7060621-7060622(+) m6A 5'UTR//exon//intron       - chr12:7060707-7060708(+) m6A exon//intron       - chr12:7064343-7064344(+) m6A 3'UTR//CDS//exon       - chr12:7064362-7064363(+) m6A 3'UTR//CDS//exon       - chr12:7064574-7064575(+) m6A 3'UTR//CDS//exon       - chr12:7064587-7064588(+) m6A 3'UTR//CDS//exon       - chr12:7064592-7064593(+) m6A 3'UTR//CDS//exon       - chr12:7064847-7064848(+) m6A CDS//exon       - chr12:7064883-7064884(+) m6A CDS//exon       - chr12:7064895-7064896(+) m6A CDS//exon       - chr12:7064907-7064908(+) m6A CDS//exon       - chr12:7065337-7065338(+) m6A CDS//exon       - chr12:7069142-7069143(+) m6A CDS//exon       - chr12:7069256-7069257(+) m6A CDS//exon       - chr12:7069279-7069280(+) m6A CDS//exon       - chr12:7069372-7069373(+) m6A CDS//exon       - chr12:7069537-7069538(+) m6A CDS//exon       - chr12:7069847-7069848(+) m6A CDS//intron       25456834 chr12:7069888-7069889(+) m6A CDS//intron       - chr12:7069968-7069969(+) m6A CDS//exon       - chr12:7069991-7069992(+) m6A CDS//exon       - chr12:7070006-7070007(+) m6A CDS//exon       - chr12:7070045-7070046(+) m6A 3'UTR//CDS//exon       - chr12:7070324-7070325(+) m6A 3'UTR//exon       - chr12:7070341-7070342(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PTPN6	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: PTPN6

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.