Basic Information:

  VIRBase ID:  

VHID00374695

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          MED1:  NM_004774     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	MED1
miRBase Accession/Entrez ID	MIMAT0003717	5469
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CRSP1//CRSP200//DRIP205//DRIP230//PBP//PPARBP//PPARGBP//RB18A//TRAP220//TRIP2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MED1	chr17:37571067(-) A-I      intronic chr17:37590039(-) A-I      intronic chr17:37590055(-) A-I      intronic chr17:37605336(-) A-I      intronic chr17:37605346(-) A-I      intronic chr17:37605365(-) A-I      intronic chr17:37605378(-) A-I      intronic chr17:37605480(-) A-I      intronic chr17:37571031(-) A-I      intronic chr17:37571026(-) A-I      intronic chr17:37571032(-) A-I      intronic chr17:37605486(-) A-I      intronic chr17:37605491(-) A-I      intronic chr17:37605502(-) A-I      intronic chr17:37605510(-) A-I      intronic chr17:37605518(-) A-I      intronic chr17:37605536(-) A-I      intronic chr17:37605531(-) A-I      intronic chr17:37605530(-) A-I      intronic chr17:37605523(-) A-I      intronic chr17:37571051(-) A-I      intronic chr17:37570268(-) A-I      intronic chr17:37570297(-) A-I      intronic chr17:37572127(-) A-I      intronic chr17:37573497(-) A-I      intronic chr17:37573520(-) A-I      intronic chr17:37574658(-) A-I      intronic chr17:37574772(-) A-I      intronic chr17:37574782(-) A-I      intronic chr17:37575580(-) A-I      intronic chr17:37583628(-) A-I      intronic chr17:37579364(-) A-I      intronic chr17:37579397(-) A-I      intronic chr17:37581310(-) A-I      intronic chr17:37581448(-) A-I      intronic chr17:37581565(-) A-I      intronic chr17:37581712(-) A-I      intronic chr17:37581791(-) A-I      intronic chr17:37581875(-) A-I      intronic chr17:37581906(-) A-I      intronic chr17:37581933(-) A-I      intronic chr17:37581973(-) A-I      intronic chr17:37582334(-) A-I      intronic chr17:37582449(-) A-I      intronic chr17:37582507(-) A-I      intronic chr17:37582592(-) A-I      intronic chr17:37582600(-) A-I      intronic chr17:37582618(-) A-I      intronic chr17:37582637(-) A-I      intronic chr17:37582885(-) A-I      intronic chr17:37583594(-) A-I      intronic chr17:37598683(-) A-I      intronic chr17:37596043(-) A-I      intronic chr17:37596028(-) A-I      intronic chr17:37596025(-) A-I      intronic chr17:37594930(-) A-I      intronic chr17:37594588(-) A-I      intronic chr17:37594174(-) A-I      intronic chr17:37602200(-) A-I      intronic chr17:37594148(-) A-I      intronic chr17:37594031(-) A-I      intronic chr17:37576553(-) A-I      intronic chr17:37583603(-) A-I      intronic chr17:37600678(-) A-I      intronic chr17:37600959(-) A-I      intronic chr17:37601010(-) A-I      intronic chr17:37601083(-) A-I      intronic chr17:37601665(-) A-I      intronic chr17:37601737(-) A-I      intronic chr17:37602094(-) A-I      intronic chr17:37603568(-) A-I      intronic chr17:37603605(-) A-I      intronic chr17:37604540(-) A-I      intronic chr17:37604545(-) A-I      intronic chr17:37593389(-) A-I      intronic chr17:37604584(-) A-I      intronic chr17:37605864(-) A-I      intronic chr17:37605956(-) A-I      intronic chr17:37606260(-) A-I      intronic chr17:37601620(-) A-I      intronic chr17:37593440(-) A-I      intronic chr17:37567471(-) A-I      intronic chr17:37593363(-) A-I      intronic chr17:37593361(-) A-I      intronic chr17:37593323(-) A-I      intronic chr17:37593314(-) A-I      intronic chr17:37593145(-) A-I      intronic chr17:37593059(-) A-I      intronic chr17:37592557(-) A-I      intronic chr17:37592514(-) A-I      intronic chr17:37592502(-) A-I      intronic chr17:37592492(-) A-I      intronic chr17:37592486(-) A-I      intronic chr17:37591383(-) A-I      intronic chr17:37591237(-) A-I      intronic chr17:37591225(-) A-I      intronic chr17:37590079(-) A-I      intronic chr17:37590063(-) A-I      intronic chr17:37589204(-) A-I      intronic chr17:37583630(-) A-I      intronic chr17:37583614(-) A-I      intronic chr17:37583629(-) A-I      intronic chr17:37567406(-) A-I      intronic chr17:37567450(-) A-I      intronic chr17:37567460(-) A-I      intronic chr17:37567726(-) A-I      intronic chr17:37568086(-) A-I      intronic chr17:37568119(-) A-I      intronic chr17:37568619(-) A-I      intronic chr17:37568923(-) A-I      intronic chr17:37568928(-) A-I      intronic chr17:37568929(-) A-I      intronic chr17:37568970(-) A-I      intronic chr17:37568992(-) A-I      intronic chr17:37570235(-) A-I      intronic chr17:37570236(-) A-I      intronic chr17:37570237(-) A-I      intronic chr17:37598686(-) A-I      intronic chr17:37598728(-) A-I      intronic chr17:37599387(-) A-I      intronic chr17:37599419(-) A-I      intronic chr17:37599448(-) A-I      intronic chr17:37599471(-) A-I      intronic chr17:37599526(-) A-I      intronic chr17:37600677(-) A-I      intronic chr17:37569695(-) A-I      intronic chr17:37577428(-) A-I      intronic chr17:37579319(-) A-I      intronic chr17:37591358(-) A-I      intronic chr17:37599393(-) A-I      intronic chr17:37593996(-) A-I      intronic chr17:37582648(-) A-I      intronic chr17:37604937(-) A-I      intronic chr17:37575070(-) A-I      intronic chr17:37570397(-) A-I      intronic chr17:37589923(-) A-I      intronic chr17:37605362(-) A-I      intronic chr17:37605517(-) A-I      intronic chr17:37581729(-) A-I      intronic chr17:37592441(-) A-I      intronic chr17:37605928(-) A-I      intronic chr17:37581972(-) A-I      intronic chr17:37591299(-) A-I      intronic chr17:37568646(-) A-I      intronic chr17:37591374(-) A-I      intronic chr17:37594998(-) A-I      intronic chr17:37593084(-) A-I      intronic chr17:37567702(-) A-I      intronic chr17:37597782(-) A-I      intronic chr17:37569498(-) A-I      intronic chr17:37585119(-) A-I      intronic chr17:37581800(-) A-I      intronic chr17:37594276(-) A-I      intronic chr17:37569697(-) A-I      intronic chr17:37599525(-) A-I      intronic chr17:37573314(-) A-I      intronic chr17:37589909(-) A-I      intronic chr17:37592426(-) A-I      intronic chr17:37592612(-) A-I      intronic chr17:37591254(-) A-I      intronic chr17:37581311(-) A-I      intronic chr17:37605601(-) A-I      intronic chr17:37578485(-) A-I      intronic chr17:37594673(-) A-I      intronic chr17:37605924(-) A-I      intronic chr17:37581271(-) A-I      intronic chr17:37590085(-) A-I      intronic chr17:37597774(-) A-I      intronic chr17:37594351(-) A-I      intronic chr17:37571194(-) A-I      intronic chr17:37581628(-) A-I      intronic chr17:37587668(-) A-I      intronic chr17:37574678(-) A-I      intronic chr17:37573202(-) A-I      intronic chr17:37575825(-) A-I      intronic chr17:37594075(-) A-I      intronic chr17:37581612(-) A-I      intronic chr17:37597768(-) A-I      intronic chr17:37593539(-) A-I      intronic chr17:37599034(-) A-I      intronic chr17:37581506(-) A-I      intronic chr17:37570444(-) A-I      intronic chr17:37575466(-) A-I      intronic chr17:37589969(-) A-I      intronic chr17:37570398(-) A-I      intronic chr17:37570393(-) A-I      intronic chr17:37604617(-) A-I      intronic chr17:37572159(-) A-I      intronic chr17:37602199(-) A-I      intronic chr17:37578645(-) A-I      intronic chr17:37568216(-) A-I      intronic chr17:37582578(-) A-I      intronic chr17:37593985(-) A-I      intronic chr17:37581447(-) A-I      intronic chr17:37598661(-) A-I      intronic chr17:37573257(-) A-I      intronic chr17:37592119(-) A-I      intronic chr17:37578128(-) A-I      intronic chr17:37581715(-) A-I      intronic chr17:37568208(-) A-I      intronic chr17:37594065(-) A-I      intronic chr17:37567727(-) A-I      intronic chr17:37594770(-) A-I      intronic chr17:37581582(-) A-I      intronic chr17:37602278(-) A-I      intronic chr17:37575365(-) A-I      intronic chr17:37602536(-) A-I      intronic chr17:37583054(-) A-I      intronic chr17:37583714(-) A-I      intronic chr17:37591260(-) A-I      intronic chr17:37591364(-) A-I      intronic chr17:37605579(-) A-I      intronic chr17:37573269(-) A-I      intronic chr17:37583325(-) A-I      intronic chr17:37568141(-) A-I      intronic chr17:37581721(-) A-I      intronic chr17:37605795(-) A-I      intronic chr17:37599392(-) A-I      intronic chr17:37567545(-) A-I      intronic chr17:37592278(-) A-I      intronic chr17:37581812(-) A-I      intronic chr17:37605155(-) A-I      intronic chr17:37594561(-) A-I      intronic chr17:37581360(-) A-I      intronic chr17:37591229(-) A-I      intronic chr17:37569505(-) A-I      intronic chr17:37581581(-) A-I      intronic chr17:37592092(-) A-I      intronic chr17:37593457(-) A-I      intronic chr17:37588885(-) A-I      intronic chr17:37581640(-) A-I      intronic chr17:37581889(-) A-I      intronic chr17:37590011(-) A-I      intronic chr17:37571193(-) A-I      intronic chr17:37599487(-) A-I      intronic chr17:37582326(-) A-I      intronic chr17:37573247(-) A-I      intronic chr17:37597901(-) A-I      intronic chr17:37600660(-) A-I      intronic chr17:37594670(-) A-I      intronic chr17:37594363(-) A-I      intronic chr17:37581720(-) A-I      intronic chr17:37605863(-) A-I      intronic chr17:37581541(-) A-I      intronic chr17:37582591(-) A-I      intronic chr17:37576655(-) A-I      intronic chr17:37582659(-) A-I      intronic chr17:37578447(-) A-I      intronic chr17:37575585(-) A-I      intronic chr17:37589945(-) A-I      intronic chr17:37590068(-) A-I      intronic chr17:37594063(-) A-I      intronic chr17:37571025(-) A-I      intronic chr17:37591234(-) A-I      intronic chr17:37579186(-) A-I      intronic chr17:37575432(-) A-I      intronic chr17:37568197(-) A-I      intronic chr17:37594599(-) A-I      intronic chr17:37567557(-) A-I      intronic chr17:37581399(-) A-I      intronic chr17:37581813(-) A-I      intronic chr17:37599395(-) A-I      intronic chr17:37604582(-) A-I      intronic chr17:37587669(-) A-I      intronic chr17:37567682(-) A-I      intronic chr17:37592321(-) A-I      intronic chr17:37582588(-) A-I      intronic chr17:37601562(-) A-I      intronic chr17:37592037(-) A-I      intronic chr17:37572161(-) A-I      intronic chr17:37599004(-) A-I      intronic chr17:37569703(-) A-I      intronic chr17:37594087(-) A-I      intronic chr17:37588907(-) A-I      intronic chr17:37599036(-) A-I      intronic chr17:37582699(-) A-I      intronic chr17:37600942(-) A-I      intronic chr17:37581608(-) A-I      intronic chr17:37592323(-) A-I      intronic chr17:37581892(-) A-I      intronic chr17:37574674(-) A-I      intronic chr17:37581551(-) A-I      intronic chr17:37606196(-) A-I      intronic chr17:37589510(-) A-I      intronic chr17:37567849(-) A-I      intronic chr17:37582686(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MED1	chr17:37576655(-) A-G intron -    22484847 chr17:37590011(-) A-G intron -    22484847 chr17:37593084(-) A-G intron -    22484847 chr17:37594670(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MED1	chr17:37560921-37560922(-) m6A 3'UTR       24981863 chr17:37561148-37561149(-) m6A 3'UTR       24284625 chr17:37561363-37561364(-) m6A 3'UTR       27371828 chr17:37561375-37561376(-) m6A 3'UTR       27371828 chr17:37561426-37561427(-) m6A 3'UTR       24284625//24981863//26404942//27371828 chr17:37561447-37561448(-) m6A 3'UTR       24284625//24981863//26404942//27371828 chr17:37561474-37561475(-) m6A 3'UTR       24284625//24981863//26404942//27371828 chr17:37563358-37563359(-) m6A 3'UTR//intron       27773535 chr17:37563425-37563426(-) m6A 3'UTR//intron       27773535 chr17:37563549-37563550(-) m6A 3'UTR//intron       27773535 chr17:37563563-37563564(-) m6A 3'UTR//intron       27773535 chr17:37563640-37563641(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr17:37563662-37563663(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr17:37563685-37563686(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr17:37563705-37563706(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr17:37563724-37563725(-) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr17:37563785-37563786(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37563809-37563810(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37563851-37563852(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37563911-37563912(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:37563917-37563918(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:37563923-37563924(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37563929-37563930(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37563935-37563936(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37563947-37563948(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37563985-37563986(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr17:37564088-37564089(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr17:37564158-37564159(-) Y 3'UTR//CDS//intron       25219674//26075521 chr17:37564184-37564185(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:37564237-37564238(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37564341-37564342(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37564391-37564392(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37564444-37564445(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr17:37564505-37564506(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37564546-37564547(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37564580-37564581(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37564619-37564620(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22608085 chr17:37564698-37564699(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22608085 chr17:37564764-37564765(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22608085 chr17:37564830-37564831(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:37564904-37564905(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:37564909-37564910(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:37564954-37564955(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:37564987-37564988(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr17:37565262-37565263(-) m6A 3'UTR//CDS//intron       24284625//27773535 chr17:37565322-37565323(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr17:37565386-37565387(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr17:37565426-37565427(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22608085 chr17:37565481-37565482(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr17:37565500-37565501(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr17:37565507-37565508(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37565571-37565572(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr17:37565588-37565589(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr17:37565721-37565722(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr17:37565861-37565862(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr17:37565991-37565992(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:37566097-37566098(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:37566119-37566120(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:37566155-37566156(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:37566311-37566312(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:37566363-37566364(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:37566376-37566377(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:37566414-37566415(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr17:37566464-37566465(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr17:37566533-37566534(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37566551-37566552(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr17:37566671-37566672(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr17:37566692-37566693(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr17:37566857-37566858(-) m6A 3'UTR//CDS       27773535 chr17:37566872-37566873(-) m6A 3'UTR//CDS       27773535 chr17:37566882-37566883(-) m6A 3'UTR//CDS       27773535 chr17:37566924-37566925(-) m6A 3'UTR//CDS       - chr17:37576095-37576096(-) m6A 3'UTR//CDS       27773535 chr17:37579622-37579623(-) m6A 3'UTR//CDS       27773535 chr17:37579651-37579652(-) m6A 3'UTR//CDS       27773535 chr17:37579680-37579681(-) m6A 3'UTR//CDS       27773535 chr17:37579957-37579958(-) m6A 3'UTR//CDS       27773535 chr17:37579965-37579966(-) m6A 3'UTR//CDS       27773535 chr17:37580929-37580930(-) m6A 3'UTR//CDS       27773535 chr17:37580946-37580947(-) m6A 3'UTR//CDS       27773535 chr17:37596696-37596697(-) Y CDS//intron       26075521 chr17:37607422-37607423(-) m6A 5'UTR       24981863 chr17:37607455-37607456(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MED1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: MED1

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.