Basic Information:

  VIRBase ID:  

VHID00374648

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          PDE3B:  NM_001363570     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	PDE3B
miRBase Accession/Entrez ID	MIMAT0003717	5140
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	cGIPDE1//HcGIP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE3B	chr11:14691071(+) A-I      intronic chr11:14691075(+) A-I      intronic chr11:14827433(+) A-I      intronic chr11:14827434(+) A-I      intronic chr11:14827435(+) A-I      intronic chr11:14827443(+) A-I      intronic chr11:14827456(+) A-I      intronic chr11:14827459(+) A-I      intronic chr11:14827461(+) A-I      intronic chr11:14827469(+) A-I      intronic chr11:14827470(+) A-I      intronic chr11:14710448(+) A-I      intronic chr11:14827477(+) A-I      intronic chr11:14827490(+) A-I      intronic chr11:14827510(+) A-I      intronic chr11:14828479(+) A-I      intronic chr11:14828480(+) A-I      intronic chr11:14828483(+) A-I      intronic chr11:14828505(+) A-I      intronic chr11:14828519(+) A-I      intronic chr11:14732983(+) A-I      intronic chr11:14713689(+) A-I      intronic chr11:14691025(+) A-I      intronic chr11:14691033(+) A-I      intronic chr11:14691040(+) A-I      intronic chr11:14691048(+) A-I      intronic chr11:14713699(+) A-I      intronic chr11:14878196(+) A-I      intronic chr11:14672259(+) A-I      intronic chr11:14692455(+) A-I      intronic chr11:14873689(+) A-I      intronic chr11:14878405(+) A-I      intronic chr11:14713722(+) A-I      intronic chr11:14783667(+) A-I      intronic chr11:14878360(+) A-I      intronic chr11:14878385(+) A-I      intronic chr11:14693431(+) A-I      intronic chr11:14767660(+) A-I      intronic chr11:14713706(+) A-I      intronic chr11:14873622(+) A-I      intronic chr11:14874351(+) A-I      intronic chr11:14878382(+) A-I      intronic chr11:14783666(+) A-I      intronic chr11:14713618(+) A-I      intronic chr11:14693395(+) A-I      intronic chr11:14776218(+) A-I      intronic chr11:14836361(+) A-I      intronic chr11:14713804(+) A-I      intronic chr11:14878379(+) A-I      intronic chr11:14681941(+) A-I      intronic chr11:14878181(+) A-I      intronic chr11:14878137(+) A-I      intronic chr11:14873882(+) A-I      intronic chr11:14874345(+) A-I      intronic chr11:14878233(+) A-I      intronic chr11:14745981(+) A-I      intronic chr11:14872468(+) A-I      intronic chr11:14835068(+) A-I      intronic chr11:14878238(+) A-I      intronic chr11:14675501(+) A-I      intronic chr11:14733866(+) A-I      intronic chr11:14878279(+) A-I      intronic chr11:14675401(+) A-I      intronic chr11:14872430(+) A-I      intronic chr11:14693319(+) A-I      intronic chr11:14876322(+) A-I      intronic chr11:14836347(+) A-I      intronic chr11:14878401(+) A-I      intronic chr11:14828685(+) A-I      intronic chr11:14693318(+) A-I      intronic chr11:14828421(+) A-I      intronic chr11:14675358(+) A-I      intronic chr11:14872455(+) A-I      intronic chr11:14835089(+) A-I      intronic chr11:14710593(+) A-I      intronic chr11:14675359(+) A-I      intronic chr11:14839197(+) A-I      intronic chr11:14872652(+) A-I      intronic chr11:14876323(+) A-I      intronic chr11:14836397(+) A-I      intronic chr11:14692452(+) A-I      intronic chr11:14878211(+) A-I      intronic chr11:14693392(+) A-I      intronic chr11:14872643(+) A-I      intronic chr11:14783643(+) A-I      intronic chr11:14733072(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE3B	chr11:14665285-14665286(+) m6A 5'UTR       24284625//25456834//22608085 chr11:14665390-14665391(+) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr11:14665444-14665445(+) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr11:14665475-14665476(+) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr11:14665517-14665518(+) m6A 5'UTR       24284625//25456834//27371828//22575960//22608085 chr11:14665745-14665746(+) m6A CDS       24284625//25456834//27371828//22575960//22608085 chr11:14665911-14665912(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr11:14666035-14666036(+) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960//22608085 chr11:14666046-14666047(+) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960//22608085 chr11:14666114-14666115(+) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960//22608085 chr11:14666527-14666528(+) m6A CDS//exon       24981863 chr11:14852255-14852256(+) m6A CDS       24981863//27773535 chr11:14852280-14852281(+) m6A CDS       24981863//27773535 chr11:14852290-14852291(+) m6A CDS       24981863//27773535 chr11:14852308-14852309(+) m6A CDS       24981863//27773535 chr11:14852321-14852322(+) m6A CDS       24981863//27773535 chr11:14852379-14852380(+) m6A CDS       24981863//27773535 chr11:14852386-14852387(+) m6A CDS       24981863//27773535 chr11:14853190-14853191(+) m6A CDS       24981863//27773535 chr11:14853207-14853208(+) m6A CDS       24981863//27773535 chr11:14853277-14853278(+) m6A CDS       24981863 chr11:14889289-14889290(+) m6A CDS       24981863//27773535//22608085 chr11:14891069-14891070(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr11:14891130-14891131(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr11:14891321-14891322(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr11:14891391-14891392(+) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr11:14891399-14891400(+) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr11:14891410-14891411(+) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr11:14891549-14891550(+) m6A 3'UTR       24284625//22608085 chr11:14891587-14891588(+) m6A 3'UTR       22608085 chr11:14892095-14892096(+) m6A 3'UTR       26404942 chr11:14892146-14892147(+) m6A 3'UTR       26404942 chr11:14892172-14892173(+) m6A 3'UTR       26404942 chr11:14892224-14892225(+) m6A 3'UTR       26404942 chr11:14892264-14892265(+) m6A 3'UTR       26404942 chr11:14892320-14892321(+) m6A 3'UTR       26404942 chr11:14892334-14892335(+) m6A 3'UTR       26404942 chr11:14892345-14892346(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PDE3B	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: PDE3B

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.