Basic Information:

  VIRBase ID:  

VHID00374573

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          CIITA:  NR_104444     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	CIITA
miRBase Accession/Entrez ID	MIMAT0003717	4261
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C2TA//CIITAIV//MHC2TA//NLRA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CIITA	chr16:11013768(+) A-I      intronic chr16:11013744(+) A-I      intronic chr16:11013737(+) A-I      intronic chr16:11013734(+) A-I      intronic chr16:10984273(+) A-I      intronic chr16:11013776(+) A-I      intronic chr16:11022225(+) A-I      3'UTR chr16:11020572(+) A-I      3'UTR chr16:10986777(+) A-I      intronic chr16:10987501(+) A-I      intronic chr16:10987513(+) A-I      intronic chr16:10987961(+) A-I      intronic chr16:11006218(+) A-I      intronic chr16:11006223(+) A-I      intronic chr16:11007191(+) A-I      intronic chr16:11007308(+) A-I      intronic chr16:10986589(+) A-I      intronic chr16:10984353(+) A-I      intronic chr16:10983597(+) A-I      intronic chr16:10983556(+) A-I      intronic chr16:10983550(+) A-I      intronic chr16:10983502(+) A-I      intronic chr16:10983477(+) A-I      intronic chr16:10978437(+) A-I      intronic chr16:10978429(+) A-I      intronic chr16:10978427(+) A-I      intronic chr16:10976373(+) A-I      intronic chr16:10984333(+) A-I      intronic chr16:11007579(+) A-I      intronic chr16:10984283(+) A-I      intronic chr16:10984205(+) A-I      intronic chr16:10983598(+) A-I      intronic chr16:10986637(+) A-I      intronic chr16:10986612(+) A-I      intronic chr16:10986776(+) A-I      intronic chr16:11007370(+) A-I      intronic chr16:11007418(+) A-I      intronic chr16:11007613(+) A-I      intronic chr16:11020524(+) A-I      3'UTR chr16:11020497(+) A-I      3'UTR chr16:11020510(+) A-I      3'UTR chr16:11020515(+) A-I      3'UTR chr16:11020421(+) A-I      3'UTR chr16:11020523(+) A-I      3'UTR chr16:11020563(+) A-I      3'UTR chr16:11018352(+) A-I      3'UTR chr16:11019215(+) A-I      3'UTR chr16:11022383(+) A-I      3'UTR chr16:11022345(+) A-I      3'UTR chr16:11022215(+) A-I      3'UTR chr16:11018342(+) A-I      3'UTR chr16:11019402(+) A-I      3'UTR chr16:11022206(+) A-I      3'UTR chr16:11020589(+) A-I      3'UTR chr16:11007301(+) A-I      intronic chr16:11007542(+) A-I      intronic chr16:11007271(+) A-I      intronic chr16:10999440(+) A-I      intronic chr16:10987898(+) A-I      intronic chr16:11007609(+) A-I      intronic chr16:11007624(+) A-I      intronic chr16:11007608(+) A-I      intronic chr16:11019216(+) A-I      3'UTR chr16:11018367(+) A-I      3'UTR chr16:11020498(+) A-I      3'UTR chr16:11019264(+) A-I      3'UTR chr16:11018118(+) A-I      3'UTR chr16:11022409(+) A-I      3'UTR chr16:10984244(+) A-I      intronic chr16:10978296(+) A-I      intronic chr16:10989589(+) A-I      NonSyn:Asp->Gly chr16:11003731(+) A-I      intronic chr16:10983408(+) A-I      intronic chr16:11007272(+) A-I      intronic chr16:11013491(+) A-I      intronic chr16:10983470(+) A-I      intronic chr16:11007311(+) A-I      intronic chr16:10999363(+) A-I      intronic chr16:11007541(+) A-I      intronic chr16:11007433(+) A-I      intronic chr16:11007687(+) A-I      intronic chr16:11007568(+) A-I      intronic chr16:11008987(+) A-I      intronic chr16:11007378(+) A-I      intronic chr16:11008982(+) A-I      intronic chr16:10999862(+) A-I      intronic chr16:11007677(+) A-I      intronic chr16:10999362(+) A-I      intronic chr16:11007651(+) A-I      intronic chr16:10986636(+) A-I      intronic chr16:11007235(+) A-I      intronic chr16:11007763(+) A-I      intronic chr16:10975112(+) A-I      intronic chr16:10986580(+) A-I      intronic chr16:10984364(+) A-I      intronic chr16:11013492(+) A-I      intronic chr16:10987944(+) A-I      intronic chr16:10981590(+) A-I      intronic chr16:11007233(+) A-I      intronic chr16:11007236(+) A-I      intronic chr16:10986588(+) A-I      intronic chr16:10978295(+) A-I      intronic chr16:10975093(+) A-I      intronic chr16:10983396(+) A-I      intronic chr16:10986660(+) A-I      intronic chr16:10981446(+) A-I      intronic chr16:11008972(+) A-I      intronic chr16:11013729(+) A-I      intronic chr16:11013732(+) A-I      intronic chr16:11013743(+) A-I      intronic chr16:11013772(+) A-I      intronic chr16:10984287(+) A-I      intronic chr16:11013716(+) A-I      intronic chr16:11013733(+) A-I      intronic chr16:11013764(+) A-I      intronic chr16:11013728(+) A-I      intronic chr16:11013526(+) A-I      intronic chr16:11007753(+) A-I      intronic chr16:10976663(+) A-I      intronic chr16:11013527(+) A-I      intronic chr16:11013773(+) A-I      intronic chr16:11013612(+) A-I      intronic chr16:11007519(+) A-I      intronic chr16:11013634(+) A-I      intronic chr16:11013506(+) A-I      intronic chr16:11013709(+) A-I      intronic chr16:11013517(+) A-I      intronic chr16:11020578(+) A-I      3'UTR chr16:11020581(+) A-I      3'UTR chr16:11018312(+) A-I      3'UTR chr16:11022263(+) A-I      3'UTR chr16:11018279(+) A-I      3'UTR chr16:11018324(+) A-I      3'UTR chr16:11019263(+) A-I      3'UTR chr16:11019419(+) A-I      3'UTR chr16:11022250(+) A-I      3'UTR chr16:11022331(+) A-I      3'UTR chr16:11018220(+) A-I      3'UTR chr16:11020583(+) A-I      3'UTR chr16:11020478(+) A-I      3'UTR chr16:11018290(+) A-I      3'UTR chr16:11020434(+) A-I      3'UTR chr16:11020459(+) A-I      3'UTR chr16:11022214(+) A-I      3'UTR chr16:11020501(+) A-I      3'UTR chr16:11018230(+) A-I      3'UTR chr16:11020462(+) A-I      3'UTR chr16:11022249(+) A-I      3'UTR chr16:11022376(+) A-I      3'UTR chr16:11022328(+) A-I      3'UTR chr16:11018299(+) A-I      3'UTR chr16:11018232(+) A-I      3'UTR chr16:11019276(+) A-I      3'UTR chr16:11018191(+) A-I      3'UTR chr16:11020598(+) A-I      3'UTR chr16:11020502(+) A-I      3'UTR chr16:11018256(+) A-I      3'UTR chr16:11018240(+) A-I      3'UTR chr16:11018273(+) A-I      3'UTR chr16:11018310(+) A-I      3'UTR chr16:11022275(+) A-I      3'UTR chr16:11022245(+) A-I      3'UTR chr16:11022246(+) A-I      3'UTR chr16:11020595(+) A-I      3'UTR chr16:11018270(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CIITA	chr16:10989589(+) A-I exon CDS    15342557 chr16:10995933(+) A-I exon CDS    15342557 chr16:11002927(+) A-I exon CDS    15342557 chr16:11018118(+) A-I exon 3'UTR    15342557 chr16:11018220(+) A-I exon 3'UTR    15342557 chr16:11018230(+) A-I exon 3'UTR    15342557 chr16:11018232(+) A-I exon 3'UTR    15342557 chr16:11018240(+) A-I exon 3'UTR    15342557 chr16:11018270(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018290(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018299(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018310(+) A-I exon 3'UTR    15342557   //15258596 chr16:11018324(+) A-I exon 3'UTR    15342557   //15258596 chr16:11013716(+) A-I intron -    22327324 chr16:11013732(+) A-I intron -    22327324 chr16:11013733(+) A-I intron -    22327324 chr16:11013716(+) A-G intron -    22484847 chr16:11013728(+) A-G intron -    22484847 chr16:11013729(+) A-G intron -    22484847 chr16:11013732(+) A-G intron -    22484847 chr16:11013733(+) A-G intron -    22484847 chr16:11013743(+) A-G intron -    22484847 chr16:11013764(+) A-G intron -    22484847 chr16:10999440(+) A-G intron -    22484847 chr16:11007608(+) A-G intron -    22484847 chr16:11007677(+) A-G intron -    22484847 chr16:11007687(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CIITA	chr16:10989249-10989250(+) m6A CDS//exon       - chr16:10989537-10989538(+) m6A CDS//exon       - chr16:10989596-10989597(+) m6A CDS//exon       - chr16:10992530-10992531(+) m6A CDS//exon       - chr16:10992535-10992536(+) m6A CDS//exon       - chr16:10992553-10992554(+) m6A CDS//exon       - chr16:10992580-10992581(+) m6A CDS//exon       - chr16:10992791-10992792(+) m6A CDS//exon       - chr16:10995934-10995935(+) m6A 3'UTR//CDS//exon//intron       - chr16:10996025-10996026(+) m6A 3'UTR//CDS//exon//intron       - chr16:10996560-10996561(+) m6A 3'UTR//CDS//exon       - chr16:10996627-10996628(+) m6A CDS//exon       - chr16:10997659-10997660(+) m6A CDS//exon       - chr16:10997720-10997721(+) m6A CDS//exon       - chr16:10997743-10997744(+) m6A CDS//exon       - chr16:11000388-11000389(+) m6A CDS//exon//intron       - chr16:11000491-11000492(+) m6A CDS//exon//intron       22575960 chr16:11000505-11000506(+) m6A CDS//exon//intron       22575960 chr16:11000585-11000586(+) m6A CDS//exon//intron       22575960 chr16:11000718-11000719(+) m6A CDS//exon//intron       - chr16:11001123-11001124(+) m6A CDS//exon//intron       - chr16:11001147-11001148(+) m6A CDS//exon//intron       - chr16:11001265-11001266(+) m6A CDS//exon//intron       - chr16:11001358-11001359(+) m6A CDS//exon//intron       22575960 chr16:11001381-11001382(+) m6A CDS//exon//intron       22575960 chr16:11001407-11001408(+) m6A CDS//exon//intron       22575960 chr16:11001537-11001538(+) m6A CDS//exon//intron       22575960 chr16:11001696-11001697(+) m6A CDS//exon//intron       22575960 chr16:11001746-11001747(+) m6A CDS//exon//intron       22575960 chr16:11001921-11001922(+) m6A CDS//exon//intron       22575960 chr16:11001933-11001934(+) m6A CDS//exon//intron       22575960 chr16:11001982-11001983(+) m6A CDS//exon//intron       - chr16:11002031-11002032(+) m6A CDS//exon//intron       - chr16:11002275-11002276(+) m6A 3'UTR//exon//intron       - chr16:11002368-11002369(+) m6A 3'UTR//exon//intron       - chr16:11002940-11002941(+) m6A CDS//exon//intron       - chr16:11004064-11004065(+) m6A CDS//exon       - chr16:11004094-11004095(+) m6A CDS//exon       - chr16:11004104-11004105(+) m6A 3'UTR//CDS//exon       - chr16:11009462-11009463(+) m6A 3'UTR//CDS//exon       - chr16:11017882-11017883(+) m6A 3'UTR//exon       - chr16:11017905-11017906(+) m6A 3'UTR//exon       - chr16:11018001-11018002(+) m6A 3'UTR//exon       - chr16:11018010-11018011(+) m6A 3'UTR//exon       - chr16:11018113-11018114(+) m6A 3'UTR//exon       - chr16:11018276-11018277(+) m6A 3'UTR//exon       - chr16:11018311-11018312(+) m6A 3'UTR//exon       - chr16:11018426-11018427(+) m6A 3'UTR//exon       - chr16:11018459-11018460(+) m6A 3'UTR//exon       - chr16:11018541-11018542(+) m6A 3'UTR//exon       22575960 chr16:11018613-11018614(+) m6A 3'UTR//exon       22575960 chr16:11018625-11018626(+) m6A 3'UTR//exon       22575960 chr16:11018650-11018651(+) m6A 3'UTR//exon       22575960 chr16:11022806-11022807(+) m6A 3'UTR//intron       27773535//22608085 chr16:11023011-11023012(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023029-11023030(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023045-11023046(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023183-11023184(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023204-11023205(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:11023372-11023373(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr16:11023378-11023379(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr16:11023482-11023483(+) m6A 3'UTR//intron       27371828 chr16:11023488-11023489(+) m6A 3'UTR//intron       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CIITA	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: CIITA

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.