Basic Information:

  VIRBase ID:  

VHID00374438

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          GTF3C2:  NM_001035521     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	GTF3C2
miRBase Accession/Entrez ID	MIMAT0003717	2976
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TFIIIC-BETA//TFIIIC110

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GTF3C2	chr2:27569047(-) A-I      intronic chr2:27569071(-) A-I      intronic chr2:27569357(-) A-I      intronic chr2:27569397(-) A-I      intronic chr2:27569759(-) A-I      intronic chr2:27572681(-) A-I      intronic chr2:27570933(-) A-I      intronic chr2:27570952(-) A-I      intronic chr2:27569058(-) A-I      intronic chr2:27561466(-) A-I      intronic chr2:27563294(-) A-I      intronic chr2:27564067(-) A-I      intronic chr2:27570963(-) A-I      intronic chr2:27564072(-) A-I      intronic chr2:27564076(-) A-I      intronic chr2:27567055(-) A-I      intronic chr2:27567064(-) A-I      intronic chr2:27567066(-) A-I      intronic chr2:27570995(-) A-I      intronic chr2:27567067(-) A-I      intronic chr2:27567086(-) A-I      intronic chr2:27568011(-) A-I      intronic chr2:27568725(-) A-I      intronic chr2:27568750(-) A-I      intronic chr2:27572679(-) A-I      intronic chr2:27573785(-) A-I      intronic chr2:27568751(-) A-I      intronic chr2:27568757(-) A-I      intronic chr2:27569041(-) A-I      intronic chr2:27564071(-) A-I      intronic chr2:27562166(-) A-I      intronic chr2:27561700(-) A-I      intronic chr2:27561677(-) A-I      intronic chr2:27561564(-) A-I      intronic chr2:27561521(-) A-I      intronic chr2:27561514(-) A-I      intronic chr2:27561496(-) A-I      intronic chr2:27561474(-) A-I      intronic chr2:27561465(-) A-I      intronic chr2:27555932(-) A-I      intronic chr2:27555931(-) A-I      intronic chr2:27555150(-) A-I      intronic chr2:27554800(-) A-I      intronic chr2:27554623(-) A-I      intronic chr2:27554486(-) A-I      intronic chr2:27554317(-) A-I      intronic chr2:27553743(-) A-I      intronic chr2:27553643(-) A-I      intronic chr2:27553625(-) A-I      intronic chr2:27570969(-) A-I      intronic chr2:27571011(-) A-I      intronic chr2:27571012(-) A-I      intronic chr2:27571026(-) A-I      intronic chr2:27571034(-) A-I      intronic chr2:27571071(-) A-I      intronic chr2:27571095(-) A-I      intronic chr2:27571159(-) A-I      intronic chr2:27571188(-) A-I      intronic chr2:27571212(-) A-I      intronic chr2:27571238(-) A-I      intronic chr2:27571245(-) A-I      intronic chr2:27571260(-) A-I      intronic chr2:27571266(-) A-I      intronic chr2:27571295(-) A-I      intronic chr2:27569029(-) A-I      intronic chr2:27569031(-) A-I      intronic chr2:27569039(-) A-I      intronic chr2:27569051(-) A-I      intronic chr2:27569055(-) A-I      intronic chr2:27569061(-) A-I      intronic chr2:27569062(-) A-I      intronic chr2:27569066(-) A-I      intronic chr2:27569067(-) A-I      intronic chr2:27569068(-) A-I      intronic chr2:27569069(-) A-I      intronic chr2:27569070(-) A-I      intronic chr2:27569094(-) A-I      intronic chr2:27569109(-) A-I      intronic chr2:27569110(-) A-I      intronic chr2:27569157(-) A-I      intronic chr2:27569166(-) A-I      intronic chr2:27569316(-) A-I      intronic chr2:27569321(-) A-I      intronic chr2:27569343(-) A-I      intronic chr2:27569350(-) A-I      intronic chr2:27569365(-) A-I      intronic chr2:27569379(-) A-I      intronic chr2:27569383(-) A-I      intronic chr2:27569396(-) A-I      intronic chr2:27569398(-) A-I      intronic chr2:27569412(-) A-I      intronic chr2:27569451(-) A-I      intronic chr2:27569490(-) A-I      intronic chr2:27569491(-) A-I      intronic chr2:27569494(-) A-I      intronic chr2:27569512(-) A-I      intronic chr2:27569529(-) A-I      intronic chr2:27569531(-) A-I      intronic chr2:27569535(-) A-I      intronic chr2:27569616(-) A-I      intronic chr2:27569622(-) A-I      intronic chr2:27569658(-) A-I      intronic chr2:27569708(-) A-I      intronic chr2:27569734(-) A-I      intronic chr2:27569737(-) A-I      intronic chr2:27569758(-) A-I      intronic chr2:27569762(-) A-I      intronic chr2:27569766(-) A-I      intronic chr2:27568018(-) A-I      intronic chr2:27571449(-) A-I      intronic chr2:27571450(-) A-I      intronic chr2:27571453(-) A-I      intronic chr2:27571454(-) A-I      intronic chr2:27571467(-) A-I      intronic chr2:27571468(-) A-I      intronic chr2:27571488(-) A-I      intronic chr2:27571503(-) A-I      intronic chr2:27571505(-) A-I      intronic chr2:27571523(-) A-I      intronic chr2:27571527(-) A-I      intronic chr2:27571549(-) A-I      intronic chr2:27571559(-) A-I      intronic chr2:27571589(-) A-I      intronic chr2:27567678(-) A-I      intronic chr2:27571595(-) A-I      intronic chr2:27571634(-) A-I      intronic chr2:27571655(-) A-I      intronic chr2:27571809(-) A-I      intronic chr2:27571815(-) A-I      intronic chr2:27571871(-) A-I      intronic chr2:27569782(-) A-I      intronic chr2:27571877(-) A-I      intronic chr2:27571882(-) A-I      intronic chr2:27571886(-) A-I      intronic chr2:27571897(-) A-I      intronic chr2:27571898(-) A-I      intronic chr2:27571941(-) A-I      intronic chr2:27571954(-) A-I      intronic chr2:27571955(-) A-I      intronic chr2:27571977(-) A-I      intronic chr2:27571983(-) A-I      intronic chr2:27572080(-) A-I      intronic chr2:27572081(-) A-I      intronic chr2:27572087(-) A-I      intronic chr2:27572126(-) A-I      intronic chr2:27572153(-) A-I      intronic chr2:27570798(-) A-I      intronic chr2:27572187(-) A-I      intronic chr2:27572192(-) A-I      intronic chr2:27572209(-) A-I      intronic chr2:27572243(-) A-I      intronic chr2:27572251(-) A-I      intronic chr2:27572286(-) A-I      intronic chr2:27572535(-) A-I      intronic chr2:27572568(-) A-I      intronic chr2:27572662(-) A-I      intronic chr2:27572702(-) A-I      intronic chr2:27572706(-) A-I      intronic chr2:27572726(-) A-I      intronic chr2:27572739(-) A-I      intronic chr2:27572753(-) A-I      intronic chr2:27572779(-) A-I      intronic chr2:27572798(-) A-I      intronic chr2:27573866(-) A-I      intronic chr2:27573867(-) A-I      intronic chr2:27573931(-) A-I      intronic chr2:27574022(-) A-I      intronic chr2:27574044(-) A-I      intronic chr2:27574113(-) A-I      intronic chr2:27574116(-) A-I      intronic chr2:27574130(-) A-I      intronic chr2:27574131(-) A-I      intronic chr2:27574135(-) A-I      intronic chr2:27574205(-) A-I      intronic chr2:27576027(-) A-I      intronic chr2:27576087(-) A-I      intronic chr2:27576091(-) A-I      intronic chr2:27576094(-) A-I      intronic chr2:27576112(-) A-I      intronic chr2:27576136(-) A-I      intronic chr2:27576148(-) A-I      intronic chr2:27576408(-) A-I      intronic chr2:27576417(-) A-I      intronic chr2:27576443(-) A-I      intronic chr2:27576444(-) A-I      intronic chr2:27576454(-) A-I      intronic chr2:27576470(-) A-I      intronic chr2:27576475(-) A-I      intronic chr2:27576482(-) A-I      intronic chr2:27576509(-) A-I      intronic chr2:27576658(-) A-I      intronic chr2:27576662(-) A-I      intronic chr2:27576750(-) A-I      intronic chr2:27576759(-) A-I      intronic chr2:27576760(-) A-I      intronic chr2:27576767(-) A-I      intronic chr2:27576790(-) A-I      intronic chr2:27576798(-) A-I      intronic chr2:27576814(-) A-I      intronic chr2:27576828(-) A-I      intronic chr2:27577034(-) A-I      intronic chr2:27577068(-) A-I      intronic chr2:27577144(-) A-I      intronic chr2:27577456(-) A-I      intronic chr2:27577459(-) A-I      intronic chr2:27577510(-) A-I      intronic chr2:27577522(-) A-I      intronic chr2:27577540(-) A-I      intronic chr2:27578205(-) A-I      intronic chr2:27578225(-) A-I      intronic chr2:27578263(-) A-I      intronic chr2:27578300(-) A-I      intronic chr2:27562187(-) A-I      intronic chr2:27562191(-) A-I      intronic chr2:27562581(-) A-I      intronic chr2:27562597(-) A-I      intronic chr2:27562609(-) A-I      intronic chr2:27562637(-) A-I      intronic chr2:27562671(-) A-I      intronic chr2:27562688(-) A-I      intronic chr2:27562691(-) A-I      intronic chr2:27562771(-) A-I      intronic chr2:27562772(-) A-I      intronic chr2:27563226(-) A-I      intronic chr2:27563274(-) A-I      intronic chr2:27563276(-) A-I      intronic chr2:27563280(-) A-I      intronic chr2:27563347(-) A-I      intronic chr2:27563352(-) A-I      intronic chr2:27563356(-) A-I      intronic chr2:27563564(-) A-I      intronic chr2:27563599(-) A-I      intronic chr2:27563612(-) A-I      intronic chr2:27563620(-) A-I      intronic chr2:27563625(-) A-I      intronic chr2:27563975(-) A-I      intronic chr2:27563979(-) A-I      intronic chr2:27564096(-) A-I      intronic chr2:27564102(-) A-I      intronic chr2:27564106(-) A-I      intronic chr2:27564149(-) A-I      intronic chr2:27564175(-) A-I      intronic chr2:27566656(-) A-I      intronic chr2:27566669(-) A-I      intronic chr2:27566695(-) A-I      intronic chr2:27566984(-) A-I      intronic chr2:27567003(-) A-I      intronic chr2:27567016(-) A-I      intronic chr2:27567024(-) A-I      intronic chr2:27567058(-) A-I      intronic chr2:27567059(-) A-I      intronic chr2:27567588(-) A-I      intronic chr2:27567594(-) A-I      intronic chr2:27567606(-) A-I      intronic chr2:27567607(-) A-I      intronic chr2:27567633(-) A-I      intronic chr2:27570893(-) A-I      intronic chr2:27570835(-) A-I      intronic chr2:27569813(-) A-I      intronic chr2:27569790(-) A-I      intronic chr2:27569786(-) A-I      intronic chr2:27567634(-) A-I      intronic chr2:27567720(-) A-I      intronic chr2:27567728(-) A-I      intronic chr2:27567766(-) A-I      intronic chr2:27567769(-) A-I      intronic chr2:27567906(-) A-I      intronic chr2:27567946(-) A-I      intronic chr2:27567985(-) A-I      intronic chr2:27576836(-) A-I      intronic chr2:27568023(-) A-I      intronic chr2:27568027(-) A-I      intronic chr2:27568131(-) A-I      intronic chr2:27568215(-) A-I      intronic chr2:27568303(-) A-I      intronic chr2:27568336(-) A-I      intronic chr2:27568338(-) A-I      intronic chr2:27568348(-) A-I      intronic chr2:27568377(-) A-I      intronic chr2:27568397(-) A-I      intronic chr2:27568416(-) A-I      intronic chr2:27568424(-) A-I      intronic chr2:27568459(-) A-I      intronic chr2:27568670(-) A-I      intronic chr2:27568677(-) A-I      intronic chr2:27568702(-) A-I      intronic chr2:27568709(-) A-I      intronic chr2:27568745(-) A-I      intronic chr2:27568755(-) A-I      intronic chr2:27568775(-) A-I      intronic chr2:27568854(-) A-I      intronic chr2:27568855(-) A-I      intronic chr2:27568951(-) A-I      intronic chr2:27568967(-) A-I      intronic chr2:27568975(-) A-I      intronic chr2:27568988(-) A-I      intronic chr2:27569019(-) A-I      intronic chr2:27567894(-) A-I      intronic chr2:27572674(-) A-I      intronic chr2:27572598(-) A-I      intronic chr2:27571051(-) A-I      intronic chr2:27572780(-) A-I      intronic chr2:27563300(-) A-I      intronic chr2:27567743(-) A-I      intronic chr2:27576757(-) A-I      intronic chr2:27568035(-) A-I      intronic chr2:27577425(-) A-I      intronic chr2:27570881(-) A-I      intronic chr2:27569386(-) A-I      intronic chr2:27566747(-) A-I      intronic chr2:27572734(-) A-I      intronic chr2:27572666(-) A-I      intronic chr2:27576174(-) A-I      intronic chr2:27578304(-) A-I      intronic chr2:27574106(-) A-I      intronic chr2:27571820(-) A-I      intronic chr2:27571185(-) A-I      intronic chr2:27576764(-) A-I      intronic chr2:27571514(-) A-I      intronic chr2:27577098(-) A-I      intronic chr2:27576494(-) A-I      intronic chr2:27571250(-) A-I      intronic chr2:27572710(-) A-I      intronic chr2:27572796(-) A-I      intronic chr2:27577619(-) A-I      intronic chr2:27570991(-) A-I      intronic chr2:27578275(-) A-I      intronic chr2:27571022(-) A-I      intronic chr2:27572675(-) A-I      intronic chr2:27569654(-) A-I      intronic chr2:27576430(-) A-I      intronic chr2:27562746(-) A-I      intronic chr2:27562152(-) A-I      intronic chr2:27571408(-) A-I      intronic chr2:27577473(-) A-I      intronic chr2:27571571(-) A-I      intronic chr2:27566701(-) A-I      intronic chr2:27566742(-) A-I      intronic chr2:27578265(-) A-I      intronic chr2:27569682(-) A-I      intronic chr2:27567776(-) A-I      intronic chr2:27576120(-) A-I      intronic chr2:27567730(-) A-I      intronic chr2:27577539(-) A-I      intronic chr2:27567181(-) A-I      intronic chr2:27567752(-) A-I      intronic chr2:27572670(-) A-I      intronic chr2:27567697(-) A-I      intronic chr2:27570829(-) A-I      intronic chr2:27570972(-) A-I      intronic chr2:27567164(-) A-I      intronic chr2:27561558(-) A-I      intronic chr2:27574091(-) A-I      intronic chr2:27563387(-) A-I      intronic chr2:27567744(-) A-I      intronic chr2:27573686(-) A-I      intronic chr2:27566702(-) A-I      intronic chr2:27567659(-) A-I      intronic chr2:27554706(-) A-I      intronic chr2:27576434(-) A-I      intronic chr2:27576138(-) A-I      intronic chr2:27577467(-) A-I      intronic chr2:27567020(-) A-I      intronic chr2:27569836(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GTF3C2	chr2:27567163(-) A-I intron -    21960545   //22327324 chr2:27567164(-) A-I intron -    21960545   //22327324 chr2:27567685(-) A-I intron -    22327324 chr2:27569386(-) A-I intron -    22327324 chr2:27569836(-) A-I intron -    22327324 chr2:27569842(-) A-I intron -    22327324 chr2:27571514(-) A-I intron -    22327324 chr2:27576754(-) A-I intron -    21960545   //22327324 chr2:27576840(-) A-I intron -    22327324 chr2:27576846(-) A-I intron -    22327324 chr2:27571588(-) A-I intron -    21960545 chr2:27576758(-) A-I intron -    21960545 chr2:27576764(-) A-I intron -    21960545 chr2:27566678(-) A-I intron -    21960545 chr2:27566747(-) A-I intron -    21960545 chr2:27567181(-) A-I intron -    21960545 chr2:27569682(-) A-I intron -    21960545 chr2:27569708(-) A-I intron -    21960545 chr2:27569766(-) A-I intron -    21960545 chr2:27577539(-) A-I intron -    21960545 chr2:27577619(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GTF3C2	chr2:27548899-27548900(-) m6A 3'UTR       24284625//27773535 chr2:27548909-27548910(-) m6A 3'UTR       24284625//27773535 chr2:27548980-27548981(-) m6A 3'UTR       24284625//24209618//27773535//22608085 chr2:27548996-27548997(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr2:27549040-27549041(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr2:27549097-27549098(-) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr2:27549166-27549167(-) m6A 3'UTR//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr2:27549256-27549257(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085 chr2:27549288-27549289(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr2:27549305-27549306(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr2:27549378-27549379(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:27549405-27549406(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:27549428-27549429(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:27549450-27549451(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:27549468-27549469(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:27549499-27549500(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:27549673-27549674(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:27549694-27549695(-) Y CDS//exon//intron       25219674//26075521 chr2:27549737-27549738(-) m6A CDS//exon//intron       24284625//24209618//24981863//22575960 chr2:27549743-27549744(-) m6A CDS//exon//intron       24284625//24209618//24981863//22575960 chr2:27550071-27550072(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr2:27550121-27550122(-) m6A 3'UTR//CDS//exon       24284625//22575960 chr2:27550913-27550914(-) m6A 3'UTR//CDS//exon       24284625 chr2:27550944-27550945(-) m6A 3'UTR//CDS//exon       24284625 chr2:27550956-27550957(-) m6A 3'UTR//CDS//exon       24284625 chr2:27551003-27551004(-) m6A 3'UTR//CDS//exon       24284625 chr2:27551021-27551022(-) m6A 3'UTR//CDS//exon       24284625 chr2:27551081-27551082(-) m6A exon//intron       24284625 chr2:27560412-27560413(-) m6A CDS//exon       24284625 chr2:27560795-27560796(-) m6A CDS//exon       24284625 chr2:27560878-27560879(-) m6A CDS//exon       24284625 chr2:27560884-27560885(-) m6A CDS//exon       24284625 chr2:27560942-27560943(-) m6A exon//intron       24284625 chr2:27564862-27564863(-) m6A CDS       24284625//27773535 chr2:27564929-27564930(-) m6A CDS       24284625//22575960 chr2:27565000-27565001(-) m6A CDS       24284625//22575960 chr2:27565078-27565079(-) m6A CDS       24284625 chr2:27565732-27565733(-) m6A CDS       24284625 chr2:27565740-27565741(-) m6A CDS       24284625 chr2:27565785-27565786(-) m6A CDS       24284625 chr2:27565942-27565943(-) m6A CDS       24284625//24981863//27773536 chr2:27566181-27566182(-) m6A CDS       27773536 chr2:27566187-27566188(-) m6A CDS       27773536 chr2:27566309-27566310(-) m6A CDS       25456834//24981863//27371828 chr2:27566340-27566341(-) m6A CDS       25456834//24981863//27371828//22608085 chr2:27566350-27566351(-) m6A CDS       25456834//24981863//27371828//22608085 chr2:27566365-27566366(-) m6A CDS       24284625//25456834//24981863//27371828//22608085 chr2:27573216-27573217(-) m6A 5'UTR//intron       25456834//24981863//27371828 chr2:27573461-27573462(-) m6A 5'UTR//intron       24981863 chr2:27573496-27573497(-) m6A 5'UTR//intron       24981863 chr2:27579215-27579216(-) m6A 5'UTR//intron       24284625 chr2:27579269-27579270(-) m6A 5'UTR//intron       24284625//25456834//22608085 chr2:27579294-27579295(-) m6A 5'UTR//intron       22608085 chr2:27579303-27579304(-) m6A 5'UTR//intron       24981863//22608085 chr2:27579616-27579617(-) m6A 5'UTR       24981863//22608085 chr2:27579628-27579629(-) m6A 5'UTR       24981863 chr2:27579634-27579635(-) m6A 5'UTR       24981863//22575960 chr2:27579654-27579655(-) m6A 5'UTR       24981863//22575960 chr2:27579665-27579666(-) m6A 5'UTR       22575960 chr2:27579741-27579742(-) m6A 5'UTR       22575960 chr2:27579763-27579764(-) m6A 5'UTR       24981863 chr2:27579833-27579834(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GTF3C2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: GTF3C2

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	25012295	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.