Basic Information:

  VIRBase ID:  

VHID00374202

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9523

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART18-5p:  MIMAT0003717          TMEM50B:  NR_040016     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART18-5p	TMEM50B
miRBase Accession/Entrez ID	MIMAT0003717	757
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C21orf4//HCVP7TP3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM50B	chr21:34822643(-) A-I      3'UTR chr21:34822675(-) A-I      3'UTR chr21:34827686(-) A-I      intronic chr21:34822678(-) A-I      3'UTR chr21:34822706(-) A-I      3'UTR chr21:34827671(-) A-I      intronic chr21:34822704(-) A-I      3'UTR chr21:34822674(-) A-I      3'UTR chr21:34822673(-) A-I      3'UTR chr21:34825579(-) A-I      intronic chr21:34829764(-) A-I      intronic chr21:34827694(-) A-I      intronic chr21:34822676(-) A-I      3'UTR chr21:34822696(-) A-I      3'UTR chr21:34822681(-) A-I      3'UTR chr21:34847747(-) A-I      intronic chr21:34848607(-) A-I      intronic chr21:34848614(-) A-I      intronic chr21:34848627(-) A-I      intronic chr21:34848940(-) A-I      intronic chr21:34849005(-) A-I      intronic chr21:34849006(-) A-I      intronic chr21:34849021(-) A-I      intronic chr21:34849054(-) A-I      intronic chr21:34850034(-) A-I      intronic chr21:34828543(-) A-I      intronic chr21:34848887(-) A-I      intronic chr21:34830758(-) A-I      intronic chr21:34827258(-) A-I      intronic chr21:34841504(-) A-I      intronic chr21:34836964(-) A-I      intronic chr21:34836779(-) A-I      intronic chr21:34836669(-) A-I      intronic chr21:34836616(-) A-I      intronic chr21:34836602(-) A-I      intronic chr21:34836594(-) A-I      intronic chr21:34836590(-) A-I      intronic chr21:34835547(-) A-I      intronic chr21:34835523(-) A-I      intronic chr21:34835513(-) A-I      intronic chr21:34835477(-) A-I      intronic chr21:34830735(-) A-I      intronic chr21:34830712(-) A-I      intronic chr21:34827706(-) A-I      intronic chr21:34827656(-) A-I      intronic chr21:34827312(-) A-I      intronic chr21:34827276(-) A-I      intronic chr21:34827275(-) A-I      intronic chr21:34841585(-) A-I      intronic chr21:34826811(-) A-I      intronic chr21:34826796(-) A-I      intronic chr21:34826673(-) A-I      intronic chr21:34826363(-) A-I      intronic chr21:34826352(-) A-I      intronic chr21:34825553(-) A-I      intronic chr21:34841672(-) A-I      intronic chr21:34846865(-) A-I      intronic chr21:34847407(-) A-I      intronic chr21:34847412(-) A-I      intronic chr21:34847512(-) A-I      intronic chr21:34847765(-) A-I      intronic chr21:34848097(-) A-I      intronic chr21:34848139(-) A-I      intronic chr21:34848149(-) A-I      intronic chr21:34848471(-) A-I      intronic chr21:34827212(-) A-I      intronic chr21:34848484(-) A-I      intronic chr21:34841490(-) A-I      intronic chr21:34819338(-) A-I      ncRNA chr21:34819403(-) A-I      ncRNA chr21:34836740(-) A-I      intronic chr21:34826166(-) A-I      intronic chr21:34826746(-) A-I      intronic chr21:34837099(-) A-I      intronic chr21:34826801(-) A-I      intronic chr21:34836746(-) A-I      intronic chr21:34836896(-) A-I      intronic chr21:34826710(-) A-I      intronic chr21:34828603(-) A-I      intronic chr21:34827621(-) A-I      intronic chr21:34836988(-) A-I      intronic chr21:34849363(-) A-I      intronic chr21:34836053(-) A-I      intronic chr21:34847792(-) A-I      intronic chr21:34836615(-) A-I      intronic chr21:34830709(-) A-I      intronic chr21:34836643(-) A-I      intronic chr21:34829559(-) A-I      intronic chr21:34837042(-) A-I      intronic chr21:34836531(-) A-I      intronic chr21:34848017(-) A-I      intronic chr21:34847733(-) A-I      intronic chr21:34827669(-) A-I      intronic chr21:34847372(-) A-I      intronic chr21:34837051(-) A-I      intronic chr21:34826764(-) A-I      intronic chr21:34829478(-) A-I      intronic chr21:34838554(-) A-I      intronic chr21:34847371(-) A-I      intronic chr21:34836003(-) A-I      intronic chr21:34847378(-) A-I      intronic chr21:34827399(-) A-I      intronic chr21:34847926(-) A-I      intronic chr21:34829452(-) A-I      intronic chr21:34836710(-) A-I      intronic chr21:34838521(-) A-I      intronic chr21:34839636(-) A-I      intronic chr21:34827742(-) A-I      intronic chr21:34826840(-) A-I      intronic chr21:34827672(-) A-I      intronic chr21:34825502(-) A-I      intronic chr21:34826821(-) A-I      intronic chr21:34826245(-) A-I      intronic chr21:34846919(-) A-I      intronic chr21:34830745(-) A-I      intronic chr21:34836672(-) A-I      intronic chr21:34848043(-) A-I      intronic chr21:34822775(-) A-I      3'UTR chr21:34822716(-) A-I      3'UTR chr21:34822538(-) A-I      3'UTR chr21:34822684(-) A-I      3'UTR chr21:34822642(-) A-I      3'UTR chr21:34822729(-) A-I      3'UTR chr21:34825535(-) A-I      intronic chr21:34825534(-) A-I      intronic chr21:34825676(-) A-I      intronic chr21:34848879(-) A-I      intronic chr21:34827689(-) A-I      intronic chr21:34826669(-) A-I      intronic chr21:34837029(-) A-I      intronic chr21:34826704(-) A-I      intronic chr21:34836653(-) A-I      intronic chr21:34828617(-) A-I      intronic chr21:34826857(-) A-I      intronic chr21:34835516(-) A-I      intronic chr21:34825499(-) A-I      intronic chr21:34826682(-) A-I      intronic chr21:34827324(-) A-I      intronic chr21:34836113(-) A-I      intronic chr21:34826323(-) A-I      intronic chr21:34827626(-) A-I      intronic chr21:34825570(-) A-I      intronic chr21:34826334(-) A-I      intronic chr21:34827661(-) A-I      intronic chr21:34836734(-) A-I      intronic chr21:34847475(-) A-I      intronic chr21:34827638(-) A-I      intronic chr21:34836950(-) A-I      intronic chr21:34829836(-) A-I      intronic chr21:34836601(-) A-I      intronic chr21:34827379(-) A-I      intronic chr21:34847791(-) A-I      intronic chr21:34828575(-) A-I      intronic chr21:34827565(-) A-I      intronic chr21:34827725(-) A-I      intronic chr21:34828534(-) A-I      intronic chr21:34826267(-) A-I      intronic chr21:34848603(-) A-I      intronic chr21:34830812(-) A-I      intronic chr21:34827726(-) A-I      intronic chr21:34847722(-) A-I      intronic chr21:34836956(-) A-I      intronic chr21:34847465(-) A-I      intronic chr21:34848663(-) A-I      intronic chr21:34825590(-) A-I      intronic chr21:34825493(-) A-I      intronic chr21:34825525(-) A-I      intronic chr21:34827622(-) A-I      intronic chr21:34827436(-) A-I      intronic chr21:34848072(-) A-I      intronic chr21:34826729(-) A-I      intronic chr21:34828598(-) A-I      intronic chr21:34826745(-) A-I      intronic chr21:34836689(-) A-I      intronic chr21:34827179(-) A-I      intronic chr21:34848825(-) A-I      intronic chr21:34826358(-) A-I      intronic chr21:34819374(-) A-I      ncRNA chr21:34819387(-) A-I      ncRNA chr21:34819350(-) A-I      ncRNA chr21:34819398(-) A-I      ncRNA chr21:34819367(-) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM50B	chr21:34826746(-) A-I intron -    22327324 chr21:34810933(-) A-I intron -    22327324 chr21:34818636(-) A-G intron -    22484847 chr21:34818743(-) A-G intron -    22484847 chr21:34826745(-) A-G intron -    22484847 chr21:34826746(-) A-G intron -    22484847 chr21:34828621(-) A-G intron -    22484847 chr21:34848879(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM50B	chr21:34804967-34804968(-) m6A 3'UTR//exon       27773535 chr21:34804996-34804997(-) m6A 3'UTR//exon       27773535 chr21:34805008-34805009(-) m6A 3'UTR//exon       27773535 chr21:34805096-34805097(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr21:34809215-34809216(-) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr21:34809252-34809253(-) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr21:34822508-34822509(-) m6A 3'UTR       24981863 chr21:34822531-34822532(-) m6A 3'UTR       24981863 chr21:34822920-34822921(-) m6A 3'UTR       27773535 chr21:34822945-34822946(-) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TMEM50B	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART18-5p
Interactor2: TMEM50B

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	25012295	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BL2 cells//BJAB cells	Interactor2 expression	None
Description	BART 18-5p is one of the miRNAs that are abundantly expressed in latently infected resting memory B cells in vivo, with 300 copies per cell. Because EBV does not express any proteins in latently infected memory B cells, high levels of 18-5p expression may suggest a role for this miRNA in maintenance of viral latency. In this paper, we report on the identification of a target gene for 18-5p that implicates it in maintaining latency by suppressing viral replication.