Basic Information:

  VIRBase ID:  

VHID00370507

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART17-5p:  MIMAT0003715          GRPEL2:  NM_152407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART17-5p	GRPEL2
miRBase Accession/Entrez ID	MIMAT0003715	134266
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	Mt-GrpE#2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GRPEL2	chr5:148728733(+) A-I      intronic chr5:148726430(+) A-I      intronic chr5:148728719(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GRPEL2	chr5:148725100-148725101(+) m6A 5'UTR       24284625//24981863 chr5:148725214-148725215(+) m6A exon//intron       24284625//24981863 chr5:148725347-148725348(+) m6A exon//intron       - chr5:148727871-148727872(+) m6A CDS//exon       - chr5:148727884-148727885(+) m6A CDS//exon       - chr5:148727899-148727900(+) m6A CDS//exon       - chr5:148727960-148727961(+) m6A CDS//exon       27773535 chr5:148729250-148729251(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729264-148729265(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729412-148729413(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:148730501-148730502(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr5:148730533-148730534(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730570-148730571(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730661-148730662(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730703-148730704(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730763-148730764(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730778-148730779(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730838-148730839(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730859-148730860(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730909-148730910(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr5:148733905-148733906(+) m6A 3'UTR//exon       27773535 chr5:148734025-148734026(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734052-148734053(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734081-148734082(+) m6A 3'UTR//exon       27773535 chr5:148734111-148734112(+) m6A 3'UTR//exon       27773535 chr5:148734125-148734126(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GRPEL2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART17-5p
Interactor2: GRPEL2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.