Basic Information:

  VIRBase ID:  

VHID00369343

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART17-5p:  MIMAT0003715          UBFD1:  NM_019116     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART17-5p	UBFD1
miRBase Accession/Entrez ID	MIMAT0003715	56061
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	UBPH

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBFD1	chr16:23579622(+) A-I      intronic chr16:23579646(+) A-I      intronic chr16:23580833(+) A-I      intronic chr16:23579987(+) A-I      intronic chr16:23579939(+) A-I      intronic chr16:23579922(+) A-I      intronic chr16:23579895(+) A-I      intronic chr16:23579678(+) A-I      intronic chr16:23579666(+) A-I      intronic chr16:23579661(+) A-I      intronic chr16:23579655(+) A-I      intronic chr16:23579638(+) A-I      intronic chr16:23579574(+) A-I      intronic chr16:23580033(+) A-I      intronic chr16:23579993(+) A-I      intronic chr16:23579691(+) A-I      intronic chr16:23579963(+) A-I      intronic chr16:23579681(+) A-I      intronic chr16:23579610(+) A-I      intronic chr16:23579988(+) A-I      intronic chr16:23577905(+) A-I      intronic chr16:23579887(+) A-I      intronic chr16:23580729(+) A-I      intronic chr16:23579633(+) A-I      intronic chr16:23577917(+) A-I      intronic chr16:23577799(+) A-I      intronic chr16:23577847(+) A-I      intronic chr16:23580689(+) A-I      intronic chr16:23579864(+) A-I      intronic chr16:23579979(+) A-I      intronic chr16:23580020(+) A-I      intronic chr16:23579740(+) A-I      intronic chr16:23579753(+) A-I      intronic chr16:23580737(+) A-I      intronic chr16:23579620(+) A-I      intronic chr16:23579545(+) A-I      intronic chr16:23579984(+) A-I      intronic chr16:23580673(+) A-I      intronic chr16:23580777(+) A-I      intronic chr16:23580029(+) A-I      intronic chr16:23580603(+) A-I      intronic chr16:23579555(+) A-I      intronic chr16:23579953(+) A-I      intronic chr16:23580069(+) A-I      intronic chr16:23580755(+) A-I      intronic chr16:23579741(+) A-I      intronic chr16:23577961(+) A-I      intronic chr16:23579892(+) A-I      intronic chr16:23580070(+) A-I      intronic chr16:23580765(+) A-I      intronic chr16:23580082(+) A-I      intronic chr16:23579975(+) A-I      intronic chr16:23580699(+) A-I      intronic chr16:23579954(+) A-I      intronic chr16:23579978(+) A-I      intronic chr16:23580025(+) A-I      intronic chr16:23579981(+) A-I      intronic chr16:23580826(+) A-I      intronic chr16:23579980(+) A-I      intronic chr16:23580019(+) A-I      intronic chr16:23580112(+) A-I      intronic chr16:23579664(+) A-I      intronic chr16:23580756(+) A-I      intronic chr16:23579886(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBFD1	chr16:23580019(+) A-I intron -    15342557 chr16:23580020(+) A-I intron -    15342557 chr16:23580025(+) A-I intron -    15342557 chr16:23580112(+) A-I intron -    15342557 chr16:23580603(+) A-I intron -    15342557 chr16:23580756(+) A-I intron -    15342557 chr16:23580777(+) A-I intron -    15342557 chr16:23570696(+) C-A intron -    22484847 chr16:23579610(+) A-G intron -    22484847 chr16:23579930(+) A-G intron -    22484847 chr16:23579954(+) A-G intron -    22484847 chr16:23579978(+) A-G intron -    22484847 chr16:23579980(+) A-G intron -    22484847 chr16:23580019(+) A-G intron -    22484847 chr16:23580020(+) A-G intron -    22484847 chr16:23580025(+) A-G intron -    22484847 chr16:23580112(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBFD1	chr16:23568712-23568713(+) m6A 5'UTR       24981863 chr16:23568910-23568911(+) m6A 5'UTR       24981863 chr16:23568943-23568944(+) m6A 5'UTR       24981863 chr16:23569175-23569176(+) m6A exon//intron       24981863 chr16:23569211-23569212(+) m6A exon//intron       24209618//25456834//24981863 chr16:23569280-23569281(+) m6A CDS//exon       24209618//25456834//24981863 chr16:23569291-23569292(+) m6A CDS//exon       24209618//25456834//24981863 chr16:23569305-23569306(+) m6A CDS//exon       24209618//25456834//24981863//22575960 chr16:23569381-23569382(+) m6A CDS//exon       24209618//24981863//22575960 chr16:23569435-23569436(+) m6A CDS//exon       24209618//27773536//22575960 chr16:23569504-23569505(+) m6A CDS//exon       24209618 chr16:23569527-23569528(+) m6A CDS//exon       24209618 chr16:23569555-23569556(+) m6A CDS//exon       24209618 chr16:23569577-23569578(+) m6A CDS//exon       24209618 chr16:23570923-23570924(+) m6A CDS//exon       24981863 chr16:23570968-23570969(+) m6A CDS//exon       24981863 chr16:23578356-23578357(+) m6A CDS//exon       24284625 chr16:23578368-23578369(+) m6A CDS//exon       24284625 chr16:23578376-23578377(+) m6A CDS//exon       24284625//24981863 chr16:23581879-23581880(+) m6A CDS//exon       24284625//24981863//22608085 chr16:23581937-23581938(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr16:23581955-23581956(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr16:23582003-23582004(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22608085 chr16:23584662-23584663(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBFD1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART17-5p
Interactor2: UBFD1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.