Basic Information:

  VIRBase ID:  

VHID00368880

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART17-5p:  MIMAT0003715          MINK1:  NM_001321236     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART17-5p	MINK1
miRBase Accession/Entrez ID	MIMAT0003715	50488
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	B55//MAP4K6//MINK//YSK2//ZC3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MINK1	chr17:4765030(+) A-I      intronic chr17:4775956(+) A-I      intronic chr17:4775946(+) A-I      intronic chr17:4791784(+) A-I      intronic chr17:4775973(+) A-I      intronic chr17:4768933(+) A-I      intronic chr17:4738751(+) A-I      intronic chr17:4738736(+) A-I      intronic chr17:4738735(+) A-I      intronic chr17:4774103(+) A-I      intronic chr17:4778909(+) A-I      intronic chr17:4778903(+) A-I      intronic chr17:4774560(+) A-I      intronic chr17:4778892(+) A-I      intronic chr17:4746646(+) A-I      intronic chr17:4746698(+) A-I      intronic chr17:4747413(+) A-I      intronic chr17:4747453(+) A-I      intronic chr17:4774726(+) A-I      intronic chr17:4771013(+) A-I      intronic chr17:4770880(+) A-I      intronic chr17:4738761(+) A-I      intronic chr17:4791359(+) A-I      intronic chr17:4774075(+) A-I      intronic chr17:4772148(+) A-I      intronic chr17:4772157(+) A-I      intronic chr17:4772455(+) A-I      intronic chr17:4791364(+) A-I      intronic chr17:4775947(+) A-I      intronic chr17:4773619(+) A-I      intronic chr17:4775887(+) A-I      intronic chr17:4775812(+) A-I      intronic chr17:4775523(+) A-I      intronic chr17:4770716(+) A-I      intronic chr17:4774660(+) A-I      intronic chr17:4791368(+) A-I      intronic chr17:4777177(+) A-I      intronic chr17:4777043(+) A-I      intronic chr17:4777039(+) A-I      intronic chr17:4777014(+) A-I      intronic chr17:4776978(+) A-I      intronic chr17:4738766(+) A-I      intronic chr17:4791391(+) A-I      intronic chr17:4791481(+) A-I      intronic chr17:4791652(+) A-I      intronic chr17:4775970(+) A-I      intronic chr17:4791718(+) A-I      intronic chr17:4791771(+) A-I      intronic chr17:4791842(+) A-I      intronic chr17:4791845(+) A-I      intronic chr17:4791854(+) A-I      intronic chr17:4791861(+) A-I      intronic chr17:4775960(+) A-I      intronic chr17:4775952(+) A-I      intronic chr17:4791868(+) A-I      intronic chr17:4747476(+) A-I      intronic chr17:4747493(+) A-I      intronic chr17:4747558(+) A-I      intronic chr17:4787096(+) A-I      intronic chr17:4787093(+) A-I      intronic chr17:4787080(+) A-I      intronic chr17:4787018(+) A-I      intronic chr17:4786944(+) A-I      intronic chr17:4786761(+) A-I      intronic chr17:4786760(+) A-I      intronic chr17:4786665(+) A-I      intronic chr17:4786639(+) A-I      intronic chr17:4784048(+) A-I      intronic chr17:4783730(+) A-I      intronic chr17:4783685(+) A-I      intronic chr17:4772493(+) A-I      intronic chr17:4749031(+) A-I      intronic chr17:4749048(+) A-I      intronic chr17:4779292(+) A-I      intronic chr17:4779220(+) A-I      intronic chr17:4767544(+) A-I      intronic chr17:4749097(+) A-I      intronic chr17:4750078(+) A-I      intronic chr17:4750585(+) A-I      intronic chr17:4750597(+) A-I      intronic chr17:4750603(+) A-I      intronic chr17:4750637(+) A-I      intronic chr17:4752971(+) A-I      intronic chr17:4753032(+) A-I      intronic chr17:4755086(+) A-I      intronic chr17:4755094(+) A-I      intronic chr17:4755181(+) A-I      intronic chr17:4758277(+) A-I      intronic chr17:4758292(+) A-I      intronic chr17:4758316(+) A-I      intronic chr17:4758318(+) A-I      intronic chr17:4760901(+) A-I      intronic chr17:4760907(+) A-I      intronic chr17:4760927(+) A-I      intronic chr17:4761024(+) A-I      intronic chr17:4761039(+) A-I      intronic chr17:4762873(+) A-I      intronic chr17:4762897(+) A-I      intronic chr17:4762907(+) A-I      intronic chr17:4773606(+) A-I      intronic chr17:4762918(+) A-I      intronic chr17:4764865(+) A-I      intronic chr17:4764896(+) A-I      intronic chr17:4764987(+) A-I      intronic chr17:4765672(+) A-I      intronic chr17:4765694(+) A-I      intronic chr17:4765851(+) A-I      intronic chr17:4765855(+) A-I      intronic chr17:4765878(+) A-I      intronic chr17:4746516(+) A-I      intronic chr17:4767116(+) A-I      intronic chr17:4767214(+) A-I      intronic chr17:4767551(+) A-I      intronic chr17:4771291(+) A-I      intronic chr17:4770712(+) A-I      intronic chr17:4767148(+) A-I      intronic chr17:4753082(+) A-I      intronic chr17:4778806(+) A-I      intronic chr17:4772686(+) A-I      intronic chr17:4747570(+) A-I      intronic chr17:4786161(+) A-I      intronic chr17:4786539(+) A-I      intronic chr17:4761037(+) A-I      intronic chr17:4767185(+) A-I      intronic chr17:4775610(+) A-I      intronic chr17:4773870(+) A-I      intronic chr17:4777040(+) A-I      intronic chr17:4791810(+) A-I      intronic chr17:4778912(+) A-I      intronic chr17:4786206(+) A-I      intronic chr17:4762827(+) A-I      intronic chr17:4775757(+) A-I      intronic chr17:4769690(+) A-I      intronic chr17:4740465(+) A-I      intronic chr17:4769139(+) A-I      intronic chr17:4791301(+) A-I      intronic chr17:4755032(+) A-I      intronic chr17:4792092(+) A-I      intronic chr17:4786337(+) A-I      intronic chr17:4767223(+) A-I      intronic chr17:4747366(+) A-I      intronic chr17:4761002(+) A-I      intronic chr17:4786138(+) A-I      intronic chr17:4778988(+) A-I      intronic chr17:4758356(+) A-I      intronic chr17:4779190(+) A-I      intronic chr17:4779352(+) A-I      intronic chr17:4760862(+) A-I      intronic chr17:4792059(+) A-I      intronic chr17:4780277(+) A-I      intronic chr17:4786251(+) A-I      intronic chr17:4765830(+) A-I      intronic chr17:4772695(+) A-I      intronic chr17:4769686(+) A-I      intronic chr17:4786376(+) A-I      intronic chr17:4783674(+) A-I      intronic chr17:4792093(+) A-I      intronic chr17:4783844(+) A-I      intronic chr17:4752044(+) A-I      intronic chr17:4760911(+) A-I      intronic chr17:4786579(+) A-I      intronic chr17:4775701(+) A-I      intronic chr17:4738815(+) A-I      intronic chr17:4786232(+) A-I      intronic chr17:4791775(+) A-I      intronic chr17:4745262(+) A-I      intronic chr17:4761937(+) A-I      intronic chr17:4786296(+) A-I      intronic chr17:4786144(+) A-I      intronic chr17:4755227(+) A-I      intronic chr17:4770942(+) A-I      intronic chr17:4786852(+) A-I      intronic chr17:4763004(+) A-I      intronic chr17:4746607(+) A-I      intronic chr17:4749075(+) A-I      intronic chr17:4779275(+) A-I      intronic chr17:4775532(+) A-I      intronic chr17:4773614(+) A-I      intronic chr17:4758604(+) A-I      intronic chr17:4786258(+) A-I      intronic chr17:4786145(+) A-I      intronic chr17:4786153(+) A-I      intronic chr17:4769949(+) A-I      intronic chr17:4764925(+) A-I      intronic chr17:4769091(+) A-I      intronic chr17:4775856(+) A-I      intronic chr17:4786214(+) A-I      intronic chr17:4758341(+) A-I      intronic chr17:4758858(+) A-I      intronic chr17:4748970(+) A-I      intronic chr17:4774769(+) A-I      intronic chr17:4760937(+) A-I      intronic chr17:4753068(+) A-I      intronic chr17:4774625(+) A-I      intronic chr17:4772807(+) A-I      intronic chr17:4767995(+) A-I      intronic chr17:4761001(+) A-I      intronic chr17:4740218(+) A-I      intronic chr17:4784101(+) A-I      intronic chr17:4774070(+) A-I      intronic chr17:4780286(+) A-I      intronic chr17:4783698(+) A-I      intronic chr17:4773977(+) A-I      intronic chr17:4746653(+) A-I      intronic chr17:4770986(+) A-I      intronic chr17:4768902(+) A-I      intronic chr17:4745261(+) A-I      intronic chr17:4775880(+) A-I      intronic chr17:4755062(+) A-I      intronic chr17:4773999(+) A-I      intronic chr17:4786773(+) A-I      intronic chr17:4779191(+) A-I      intronic chr17:4779272(+) A-I      intronic chr17:4787040(+) A-I      intronic chr17:4760943(+) A-I      intronic chr17:4751295(+) A-I      intronic chr17:4767345(+) A-I      intronic chr17:4758520(+) A-I      intronic chr17:4783856(+) A-I      intronic chr17:4767440(+) A-I      intronic chr17:4777104(+) A-I      intronic chr17:4770288(+) A-I      intronic chr17:4774026(+) A-I      intronic chr17:4773602(+) A-I      intronic chr17:4786257(+) A-I      intronic chr17:4763003(+) A-I      intronic chr17:4764895(+) A-I      intronic chr17:4747398(+) A-I      intronic chr17:4749199(+) A-I      intronic chr17:4774555(+) A-I      intronic chr17:4792184(+) A-I      intronic chr17:4755250(+) A-I      intronic chr17:4779195(+) A-I      intronic chr17:4768941(+) A-I      intronic chr17:4774603(+) A-I      intronic chr17:4791769(+) A-I      intronic chr17:4786617(+) A-I      intronic chr17:4777115(+) A-I      intronic chr17:4792132(+) A-I      intronic chr17:4758340(+) A-I      intronic chr17:4767417(+) A-I      intronic chr17:4791812(+) A-I      intronic chr17:4774768(+) A-I      intronic chr17:4760861(+) A-I      intronic chr17:4747351(+) A-I      intronic chr17:4760928(+) A-I      intronic chr17:4770512(+) A-I      intronic chr17:4778781(+) A-I      intronic chr17:4779266(+) A-I      intronic chr17:4784057(+) A-I      intronic chr17:4778881(+) A-I      intronic chr17:4784017(+) A-I      intronic chr17:4751692(+) A-I      intronic chr17:4777167(+) A-I      intronic chr17:4792594(+) A-I      intronic chr17:4745398(+) A-I      intronic chr17:4774781(+) A-I      intronic chr17:4780185(+) A-I      intronic chr17:4786706(+) A-I      intronic chr17:4758518(+) A-I      intronic chr17:4791721(+) A-I      intronic chr17:4772698(+) A-I      intronic chr17:4792073(+) A-I      intronic chr17:4775995(+) A-I      intronic chr17:4753129(+) A-I      intronic chr17:4767480(+) A-I      intronic chr17:4771469(+) A-I      intronic chr17:4786684(+) A-I      intronic chr17:4755130(+) A-I      intronic chr17:4774598(+) A-I      intronic chr17:4751929(+) A-I      intronic chr17:4765048(+) A-I      intronic chr17:4772751(+) A-I      intronic chr17:4760471(+) A-I      intronic chr17:4740362(+) A-I      intronic chr17:4759135(+) A-I      intronic chr17:4758436(+) A-I      intronic chr17:4755133(+) A-I      intronic chr17:4779297(+) A-I      intronic chr17:4764840(+) A-I      intronic chr17:4757220(+) A-I      intronic chr17:4752924(+) A-I      intronic chr17:4760946(+) A-I      intronic chr17:4772138(+) A-I      intronic chr17:4791286(+) A-I      intronic chr17:4772708(+) A-I      intronic chr17:4772730(+) A-I      intronic chr17:4774717(+) A-I      intronic chr17:4758432(+) A-I      intronic chr17:4746517(+) A-I      intronic chr17:4752001(+) A-I      intronic chr17:4755054(+) A-I      intronic chr17:4768992(+) A-I      intronic chr17:4772753(+) A-I      intronic chr17:4784097(+) A-I      intronic chr17:4783782(+) A-I      intronic chr17:4768911(+) A-I      intronic chr17:4742575(+) A-I      intronic chr17:4764913(+) A-I      intronic chr17:4771401(+) A-I      intronic chr17:4769096(+) A-I      intronic chr17:4792269(+) A-I      intronic chr17:4771035(+) A-I      intronic chr17:4769986(+) A-I      intronic chr17:4783680(+) A-I      intronic chr17:4764857(+) A-I      intronic chr17:4758351(+) A-I      intronic chr17:4773938(+) A-I      intronic chr17:4774687(+) A-I      intronic chr17:4746662(+) A-I      intronic chr17:4770597(+) A-I      intronic chr17:4760983(+) A-I      intronic chr17:4764827(+) A-I      intronic chr17:4755040(+) A-I      intronic chr17:4774563(+) A-I      intronic chr17:4784107(+) A-I      intronic chr17:4779194(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MINK1	chr17:4758356(+) A-I intron -    15545495 chr17:4758518(+) A-I intron -    15545495 chr17:4758520(+) A-I intron -    15545495 chr17:4758604(+) A-I intron -    15545495 chr17:4761001(+) A-G intron -    22484847 chr17:4777040(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MINK1	chr17:4781656-4781657(+) m6A CDS//exon       - chr17:4781664-4781665(+) m6A CDS//exon       24209618//24981863 chr17:4784446-4784447(+) m6A 3'UTR//CDS//exon       24209618//24981863 chr17:4788246-4788247(+) m6A 3'UTR//CDS//exon       22575960 chr17:4788804-4788805(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr17:4788825-4788826(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr17:4789462-4789463(+) m6A 3'UTR//CDS//exon       - chr17:4789788-4789789(+) m6A 3'UTR//CDS//exon       - chr17:4789843-4789844(+) m6A 3'UTR//CDS//exon       24981863 chr17:4789882-4789883(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535 chr17:4790409-4790410(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535 chr17:4790964-4790965(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr17:4790999-4791000(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27371828//22575960 chr17:4791018-4791019(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27371828//22575960 chr17:4793005-4793006(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//22575960 chr17:4793933-4793934(+) m6A 3'UTR//CDS//exon       24209618 chr17:4793962-4793963(+) m6A 3'UTR//CDS//exon       24209618 chr17:4794011-4794012(+) m6A 3'UTR//CDS//exon       24981863 chr17:4794257-4794258(+) m6A 3'UTR//CDS//exon       24981863 chr17:4794267-4794268(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794279-4794280(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794358-4794359(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794371-4794372(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794409-4794410(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794820-4794821(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794835-4794836(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794934-4794935(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4794950-4794951(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:4795455-4795456(+) m6A 3'UTR//CDS//exon       24284625 chr17:4796283-4796284(+) m6A 3'UTR//CDS//exon       - chr17:4796288-4796289(+) m6A 3'UTR//CDS//exon       - chr17:4796729-4796730(+) m6A 3'UTR//CDS//exon       - chr17:4796752-4796753(+) m6A 3'UTR//CDS//exon       24981863 chr17:4796792-4796793(+) m6A 3'UTR//CDS//exon       24981863 chr17:4797299-4797300(+) m6A 3'UTR//CDS//exon       - chr17:4797346-4797347(+) m6A 3'UTR//CDS//exon       24284625 chr17:4797487-4797488(+) m6A 3'UTR//CDS//exon       24284625 chr17:4797520-4797521(+) m6A 3'UTR//CDS//exon       24284625 chr17:4797562-4797563(+) m6A 3'UTR//CDS//exon       24284625 chr17:4797910-4797911(+) m6A 3'UTR//CDS//exon       - chr17:4797934-4797935(+) m6A exon//intron       - chr17:4797942-4797943(+) m6A exon//intron       - chr17:4798689-4798690(+) m6A 3'UTR//CDS//exon       22575960 chr17:4798717-4798718(+) m6A 3'UTR//CDS//exon       22575960 chr17:4799037-4799038(+) m6A 3'UTR//CDS//exon       22575960 chr17:4799084-4799085(+) m6A 3'UTR//CDS//exon       22575960 chr17:4799097-4799098(+) m6A 3'UTR//CDS//exon       22575960 chr17:4799370-4799371(+) m6A 3'UTR//CDS//exon       - chr17:4800283-4800284(+) m6A 3'UTR//exon//intron       24284625 chr17:4800556-4800557(+) m6A 3'UTR//CDS//exon       24981863 chr17:4800574-4800575(+) m6A 3'UTR//CDS//exon       24981863 chr17:4800614-4800615(+) m6A 3'UTR//exon       24284625 chr17:4801053-4801054(+) m6A 3'UTR//exon       24284625 chr17:4801102-4801103(+) m6A 3'UTR//exon       24284625//24981863 chr17:4801123-4801124(+) m6A 3'UTR//exon       24284625//24981863 chr17:4801138-4801139(+) m6A 3'UTR//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MINK1	Chromatin HCC cell line (HepG2)|K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm HCC cell line (HepG2)|K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART17-5p
Interactor2: MINK1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.