Basic Information:

  VIRBase ID:  

VHID00367086

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART17-5p:  MIMAT0003715          NF2:  NR_156186     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART17-5p	NF2
miRBase Accession/Entrez ID	MIMAT0003715	4771
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACN//BANF//merlin-1//SCH

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NF2	chr22:30042856(+) A-I      intronic chr22:30082371(+) A-I      intronic chr22:30075659(+) A-I      intronic chr22:30081634(+) A-I      intronic chr22:30042862(+) A-I      intronic chr22:30042823(+) A-I      intronic chr22:30042837(+) A-I      intronic chr22:30081629(+) A-I      intronic chr22:30081306(+) A-I      intronic chr22:30081226(+) A-I      intronic chr22:30076301(+) A-I      intronic chr22:30076275(+) A-I      intronic chr22:30076248(+) A-I      intronic chr22:30076137(+) A-I      intronic chr22:30075800(+) A-I      intronic chr22:30075654(+) A-I      intronic chr22:30075631(+) A-I      intronic chr22:30075601(+) A-I      intronic chr22:30068406(+) A-I      intronic chr22:30063368(+) A-I      intronic chr22:30063366(+) A-I      intronic chr22:30063353(+) A-I      intronic chr22:30062330(+) A-I      intronic chr22:30049354(+) A-I      intronic chr22:30049042(+) A-I      intronic chr22:30048411(+) A-I      intronic chr22:30048374(+) A-I      intronic chr22:30048358(+) A-I      intronic chr22:30048355(+) A-I      intronic chr22:30046752(+) A-I      intronic chr22:30044686(+) A-I      intronic chr22:30044667(+) A-I      intronic chr22:30042800(+) A-I      intronic chr22:30020358(+) A-I      intronic chr22:30016784(+) A-I      intronic chr22:30016572(+) A-I      intronic chr22:30016479(+) A-I      intronic chr22:30015560(+) A-I      intronic chr22:30015546(+) A-I      intronic chr22:30013178(+) A-I      intronic chr22:30012686(+) A-I      intronic chr22:30012620(+) A-I      intronic chr22:30012611(+) A-I      intronic chr22:30010424(+) A-I      intronic chr22:30010270(+) A-I      intronic chr22:30010269(+) A-I      intronic chr22:30009937(+) A-I      intronic chr22:30009309(+) A-I      intronic chr22:30009304(+) A-I      intronic chr22:30007396(+) A-I      intronic chr22:30007369(+) A-I      intronic chr22:30007239(+) A-I      intronic chr22:30006224(+) A-I      intronic chr22:30004482(+) A-I      intronic chr22:30004457(+) A-I      intronic chr22:30004456(+) A-I      intronic chr22:30004003(+) A-I      intronic chr22:30002937(+) A-I      intronic chr22:30002914(+) A-I      intronic chr22:30002875(+) A-I      intronic chr22:30002874(+) A-I      intronic chr22:30002872(+) A-I      intronic chr22:30002056(+) A-I      intronic chr22:30001534(+) A-I      intronic chr22:30076242(+) A-I      intronic chr22:30016518(+) A-I      intronic chr22:30016088(+) A-I      intronic chr22:30008391(+) A-I      intronic chr22:30002070(+) A-I      intronic chr22:30004150(+) A-I      intronic chr22:30001319(+) A-I      intronic chr22:30075837(+) A-I      intronic chr22:30002863(+) A-I      intronic chr22:30065399(+) A-I      intronic chr22:30008451(+) A-I      intronic chr22:30004041(+) A-I      intronic chr22:30010515(+) A-I      intronic chr22:30002869(+) A-I      intronic chr22:30009866(+) A-I      intronic chr22:30016817(+) A-I      intronic chr22:30012969(+) A-I      intronic chr22:30010678(+) A-I      intronic chr22:30016607(+) A-I      intronic chr22:30082373(+) A-I      intronic chr22:30062550(+) A-I      intronic chr22:30008426(+) A-I      intronic chr22:30075757(+) A-I      intronic chr22:30081236(+) A-I      intronic chr22:30004669(+) A-I      intronic chr22:30048476(+) A-I      intronic chr22:30006145(+) A-I      intronic chr22:30048394(+) A-I      intronic chr22:30008411(+) A-I      intronic chr22:30008830(+) A-I      intronic chr22:30004111(+) A-I      intronic chr22:30012522(+) A-I      intronic chr22:30001337(+) A-I      intronic chr22:30062549(+) A-I      intronic chr22:30044792(+) A-I      intronic chr22:30049271(+) A-I      intronic chr22:30044676(+) A-I      intronic chr22:30009354(+) A-I      intronic chr22:30092269(+) A-I      3'UTR chr22:30092899(+) A-I      3'UTR chr22:30092244(+) A-I      3'UTR chr22:30093068(+) A-I      3'UTR chr22:30092238(+) A-I      3'UTR chr22:30007364(+) A-I      intronic chr22:30008829(+) A-I      intronic chr22:30061699(+) A-I      intronic chr22:30045656(+) A-I      intronic chr22:30012584(+) A-I      intronic chr22:30081536(+) A-I      intronic chr22:30001399(+) A-I      intronic chr22:30004149(+) A-I      intronic chr22:30017509(+) A-I      intronic chr22:30007361(+) A-I      intronic chr22:30008588(+) A-I      intronic chr22:30001271(+) A-I      intronic chr22:30044699(+) A-I      intronic chr22:30049257(+) A-I      intronic chr22:30009849(+) A-I      intronic chr22:30081652(+) A-I      intronic chr22:30002913(+) A-I      intronic chr22:30081509(+) A-I      intronic chr22:30077090(+) A-I      intronic chr22:30009922(+) A-I      intronic chr22:30075600(+) A-I      intronic chr22:30006101(+) A-I      intronic chr22:30044683(+) A-I      intronic chr22:30006228(+) A-I      intronic chr22:30082508(+) A-I      intronic chr22:30007310(+) A-I      intronic chr22:30008437(+) A-I      intronic chr22:30004082(+) A-I      intronic chr22:30048393(+) A-I      intronic chr22:30013018(+) A-I      intronic chr22:30001343(+) A-I      intronic chr22:30007269(+) A-I      intronic chr22:30004090(+) A-I      intronic chr22:30004074(+) A-I      intronic chr22:30001254(+) A-I      intronic chr22:30046789(+) A-I      intronic chr22:30081171(+) A-I      intronic chr22:30062527(+) A-I      intronic chr22:30049226(+) A-I      intronic chr22:30075584(+) A-I      intronic chr22:30081197(+) A-I      intronic chr22:30008534(+) A-I      intronic chr22:30007405(+) A-I      intronic chr22:30011052(+) A-I      intronic chr22:30004083(+) A-I      intronic chr22:30008412(+) A-I      intronic chr22:30081371(+) A-I      intronic chr22:30012517(+) A-I      intronic chr22:30012479(+) A-I      intronic chr22:30011590(+) A-I      intronic chr22:30001356(+) A-I      intronic chr22:30075653(+) A-I      intronic chr22:30002968(+) A-I      intronic chr22:30081674(+) A-I      intronic chr22:30076780(+) A-I      intronic chr22:30045490(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NF2	chr22:30004074(+) A-I intron -    15342557 chr22:30004082(+) A-I intron -    15342557 chr22:30004083(+) A-I intron -    15342557 chr22:30004090(+) A-I intron -    15342557 chr22:30004111(+) A-I intron -    15342557 chr22:30004149(+) A-I intron -    15342557 chr22:30004150(+) A-I intron -    15342557 chr22:30093544(+) A-I intron -    21960545 chr22:30001254(+) A-G intron -    22484847 chr22:30001271(+) A-G intron -    22484847 chr22:30002968(+) A-G intron -    22484847 chr22:30007364(+) A-G intron -    22484847 chr22:30010515(+) A-G intron -    22484847 chr22:30044683(+) A-G intron -    22484847 chr22:30044699(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NF2	chr22:30067911-30067912(+) m1A CDS//intron       26863196 chr22:30069272-30069273(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr22:30069322-30069323(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr22:30070853-30070854(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr22:30074191-30074192(+) m6A CDS//intron       24209618//24981863 chr22:30077475-30077476(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077482-30077483(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077502-30077503(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077507-30077508(+) Am CDS//intron       - chr22:30077518-30077519(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077546-30077547(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30079028-30079029(+) m6A CDS//intron       24284625 chr22:30090813-30090814(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr22:30090838-30090839(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr22:30090850-30090851(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30090911-30090912(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30090964-30090965(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091158-30091159(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091214-30091215(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091238-30091239(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091425-30091426(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr22:30091534-30091535(+) m6A 3'UTR       24284625 chr22:30091719-30091720(+) m6A 3'UTR       24284625 chr22:30092198-30092199(+) m6A 3'UTR       24209618 chr22:30093362-30093363(+) m6A 3'UTR       24284625 chr22:30093370-30093371(+) m6A 3'UTR       24284625 chr22:30093524-30093525(+) m6A 3'UTR       - chr22:30093776-30093777(+) m6A 3'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NF2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART17-5p
Interactor2: NF2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.