Basic Information:

  VIRBase ID:  

VHID00366683

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8899

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART17-5p:  MIMAT0003715          FOXO3:  NM_201559     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART17-5p	FOXO3
miRBase Accession/Entrez ID	MIMAT0003715	2309
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AF6q21//FKHRL1//FKHRL1P2//FOXO2//FOXO3A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FOXO3	chr6:108906998(+) A-I      intronic chr6:108906967(+) A-I      intronic chr6:108906934(+) A-I      intronic chr6:108906945(+) A-I      intronic chr6:108906956(+) A-I      intronic chr6:108906959(+) A-I      intronic chr6:108921584(+) A-I      intronic chr6:108907006(+) A-I      intronic chr6:108906951(+) A-I      intronic chr6:108921578(+) A-I      intronic chr6:108921573(+) A-I      intronic chr6:108921571(+) A-I      intronic chr6:108986821(+) A-I      intronic chr6:108986794(+) A-I      intronic chr6:108986779(+) A-I      intronic chr6:108986771(+) A-I      intronic chr6:108921621(+) A-I      intronic chr6:108921598(+) A-I      intronic chr6:108906948(+) A-I      intronic chr6:108906908(+) A-I      intronic chr6:108906910(+) A-I      intronic chr6:108906935(+) A-I      intronic chr6:108921603(+) A-I      intronic chr6:108921593(+) A-I      intronic chr6:108921562(+) A-I      intronic chr6:108921553(+) A-I      intronic chr6:108921543(+) A-I      intronic chr6:108921539(+) A-I      intronic chr6:108921493(+) A-I      intronic chr6:108921474(+) A-I      intronic chr6:108894474(+) A-I      intronic chr6:108894455(+) A-I      intronic chr6:108894311(+) A-I      intronic chr6:108891531(+) A-I      intronic chr6:108946102(+) A-I      intronic chr6:108987808(+) A-I      intronic chr6:108987592(+) A-I      intronic chr6:108980217(+) A-I      intronic chr6:108980188(+) A-I      intronic chr6:108979896(+) A-I      intronic chr6:108979777(+) A-I      intronic chr6:108969942(+) A-I      intronic chr6:108946108(+) A-I      intronic chr6:108937336(+) A-I      intronic chr6:108937271(+) A-I      intronic chr6:108937255(+) A-I      intronic chr6:108933789(+) A-I      intronic chr6:108933736(+) A-I      intronic chr6:108933712(+) A-I      intronic chr6:108933628(+) A-I      intronic chr6:108928613(+) A-I      intronic chr6:108928415(+) A-I      intronic chr6:108922746(+) A-I      intronic chr6:108922692(+) A-I      intronic chr6:108922690(+) A-I      intronic chr6:108922687(+) A-I      intronic chr6:108922422(+) A-I      intronic chr6:108922397(+) A-I      intronic chr6:108922352(+) A-I      intronic chr6:108921725(+) A-I      intronic chr6:108921670(+) A-I      intronic chr6:108921646(+) A-I      intronic chr6:108921619(+) A-I      intronic chr6:108999975(+) A-I      intronic chr6:108963568(+) A-I      intronic chr6:108908197(+) A-I      intronic chr6:108901521(+) A-I      intronic chr6:108990075(+) A-I      intronic chr6:108981854(+) A-I      intronic chr6:108895275(+) A-I      intronic chr6:108928476(+) A-I      intronic chr6:108986770(+) A-I      intronic chr6:108921506(+) A-I      intronic chr6:109000029(+) A-I      intronic chr6:108970808(+) A-I      intronic chr6:108915086(+) A-I      intronic chr6:108895274(+) A-I      intronic chr6:108999955(+) A-I      intronic chr6:108921656(+) A-I      intronic chr6:108928501(+) A-I      intronic chr6:108969943(+) A-I      intronic chr6:108922280(+) A-I      intronic chr6:108922350(+) A-I      intronic chr6:108891622(+) A-I      intronic chr6:108922781(+) A-I      intronic chr6:108921509(+) A-I      intronic chr6:108921629(+) A-I      intronic chr6:108933763(+) A-I      intronic chr6:108928477(+) A-I      intronic chr6:108986995(+) A-I      intronic chr6:108921630(+) A-I      intronic chr6:108986904(+) A-I      intronic chr6:108901564(+) A-I      intronic chr6:108901566(+) A-I      intronic chr6:108962296(+) A-I      intronic chr6:108921699(+) A-I      intronic chr6:108986782(+) A-I      intronic chr6:108921635(+) A-I      intronic chr6:108962278(+) A-I      intronic chr6:108986845(+) A-I      intronic chr6:108963345(+) A-I      intronic chr6:108922741(+) A-I      intronic chr6:108990097(+) A-I      intronic chr6:108921695(+) A-I      intronic chr6:108921563(+) A-I      intronic chr6:108922275(+) A-I      intronic chr6:108921671(+) A-I      intronic chr6:108921700(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FOXO3	chr6:108907006(+) A-I intron -    21960545 chr6:108920780(+) A-I intron -    21960545 chr6:108921197(+) A-I intron -    21960545 chr6:108921236(+) A-I intron -    21960545 chr6:108921239(+) A-I intron -    21960545 chr6:108921302(+) A-I intron -    21960545 chr6:108999955(+) A-I intron -    21960545 chr6:108891672(+) A-G intron -    22484847 chr6:108922556(+) G-A intron -    22484847 chr6:108922741(+) A-G intron -    22484847 chr6:108937213(+) A-G intron -    22484847 chr6:108937303(+) A-G intron -    22484847 chr6:108963292(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FOXO3	chr6:108882192-108882193(+) m6A 5'UTR//intron       25456834 chr6:108882219-108882220(+) m6A 5'UTR//intron       25456834//24981863 chr6:108882466-108882467(+) m6A CDS       24284625 chr6:108882697-108882698(+) m6A CDS       24981863//22608085 chr6:108882730-108882731(+) m6A CDS       24981863//22608085 chr6:108977554-108977555(+) m6A 5'UTR//intron       24284625 chr6:108977572-108977573(+) m6A 5'UTR//intron       24284625 chr6:108984717-108984718(+) m6A CDS       24981863 chr6:108984799-108984800(+) m6A CDS       24284625//24981863//22608085 chr6:108984861-108984862(+) m6A CDS       24284625//24981863//22608085 chr6:108984958-108984959(+) m6A CDS       24284625//24981863//22608085 chr6:108985130-108985131(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr6:108985189-108985190(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr6:108985253-108985254(+) m6A CDS       24284625//24981863//22608085 chr6:108985343-108985344(+) m6A CDS       24284625//22608085 chr6:108985357-108985358(+) m6A CDS       24284625 chr6:108985383-108985384(+) m6A CDS       24284625 chr6:108985396-108985397(+) m6A CDS       24284625 chr6:108985440-108985441(+) m6A CDS       24284625 chr6:108985630-108985631(+) m6A CDS       24284625//24981863 chr6:108985653-108985654(+) m6A CDS       24284625//24981863 chr6:108985870-108985871(+) m6A CDS       24981863 chr6:108985876-108985877(+) m6A CDS       24981863 chr6:108985928-108985929(+) m6A CDS       24981863 chr6:108986008-108986009(+) m6A CDS       24284625//25456834//24981863//22608085 chr6:109001037-109001038(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr6:109001048-109001049(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr6:109001061-109001062(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr6:109001092-109001093(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr6:109001157-109001158(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:109001201-109001202(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:109001206-109001207(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:109001266-109001267(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:109001480-109001481(+) m6A 3'UTR       24981863 chr6:109001556-109001557(+) m6A 3'UTR       22608085 chr6:109001573-109001574(+) m6A 3'UTR       22608085 chr6:109001630-109001631(+) m6A 3'UTR       22608085 chr6:109001635-109001636(+) m6A 3'UTR       22608085 chr6:109001673-109001674(+) m6A 3'UTR       24981863//22608085 chr6:109001678-109001679(+) m6A 3'UTR       24981863//22608085 chr6:109001760-109001761(+) m6A 3'UTR       22608085 chr6:109001834-109001835(+) m6A 3'UTR       24284625 chr6:109003084-109003085(+) m6A 3'UTR       - chr6:109003478-109003479(+) m6A 3'UTR       - chr6:109003501-109003502(+) m6A 3'UTR       - chr6:109003516-109003517(+) m6A 3'UTR       - chr6:109003548-109003549(+) m6A 3'UTR       - chr6:109004453-109004454(+) m6A 3'UTR       24284625//24981863//22608085 chr6:109004475-109004476(+) m6A 3'UTR       24284625//24981863//22608085 chr6:109004518-109004519(+) m6A 3'UTR       24284625//24981863//22608085 chr6:109004546-109004547(+) m6A 3'UTR       24284625//24981863//22608085 chr6:109004570-109004571(+) m6A 3'UTR       24284625//24981863//22608085 chr6:109004664-109004665(+) m6A 3'UTR       24284625//24981863//22608085 chr6:109004713-109004714(+) m6A 3'UTR       24284625//24981863//22608085 chr6:109004809-109004810(+) m6A 3'UTR       24981863//22608085 chr6:109004879-109004880(+) m6A 3'UTR       24981863//22608085 chr6:109004937-109004938(+) m6A 3'UTR       24981863//22608085 chr6:109004953-109004954(+) m6A 3'UTR       24981863//22608085 chr6:109004988-109004989(+) m6A 3'UTR       24981863//22608085 chr6:109005087-109005088(+) m6A 3'UTR       22608085 chr6:109005660-109005661(+) m6A 3'UTR       22608085 chr6:109005684-109005685(+) m6A 3'UTR       22608085 chr6:109005722-109005723(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FOXO3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART17-5p
Interactor2: FOXO3

Evidence Support:

Strong-Evidence	3'UTR indicator assay
Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	30615681	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	293T cells	Interactor2 expression	None
Description	Luciferase knockdown was observed for 12 out of 15 PAR-CLIP-identified miRNA interactions, confirming these cellular 3'UTRs as targets of the EBV miRNAs (Fig 3A-3C).