Basic Information:

  VIRBase ID:  

VHID00366285

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART17-5p:  MIMAT0003715          AMD1:  NR_109768     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART17-5p	AMD1
miRBase Accession/Entrez ID	MIMAT0003715	262
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ADOMETDC//AMD//SAMDC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AMD1	chr6:111207791(+) A-I      intronic chr6:111205749(+) A-I      intronic chr6:111204314(+) A-I      intronic chr6:111204273(+) A-I      intronic chr6:111207837(+) A-I      intronic chr6:111203366(+) A-I      intronic chr6:111202873(+) A-I      intronic chr6:111202868(+) A-I      intronic chr6:111202842(+) A-I      intronic chr6:111207638(+) A-I      intronic chr6:111202061(+) A-I      intronic chr6:111201258(+) A-I      intronic chr6:111201233(+) A-I      intronic chr6:111201286(+) A-I      intronic chr6:111210813(+) A-I      intronic chr6:111207518(+) A-I      intronic chr6:111210721(+) A-I      intronic chr6:111210708(+) A-I      intronic chr6:111210705(+) A-I      intronic chr6:111207381(+) A-I      intronic chr6:111210698(+) A-I      intronic chr6:111207219(+) A-I      intronic chr6:111207909(+) A-I      intronic chr6:111208968(+) A-I      intronic chr6:111211801(+) A-I      intronic chr6:111207203(+) A-I      intronic chr6:111204212(+) A-I      intronic chr6:111202050(+) A-I      intronic chr6:111202015(+) A-I      intronic chr6:111207695(+) A-I      intronic chr6:111207706(+) A-I      intronic chr6:111207933(+) A-I      intronic chr6:111207729(+) A-I      intronic chr6:111207731(+) A-I      intronic chr6:111198976(+) A-I      intronic chr6:111198986(+) A-I      intronic chr6:111201223(+) A-I      intronic chr6:111204151(+) A-I      intronic chr6:111204072(+) A-I      intronic chr6:111203396(+) A-I      intronic chr6:111207878(+) A-I      intronic chr6:111202804(+) A-I      intronic chr6:111204195(+) A-I      intronic chr6:111204112(+) A-I      intronic chr6:111202018(+) A-I      intronic chr6:111207302(+) A-I      intronic chr6:111209005(+) A-I      intronic chr6:111208945(+) A-I      intronic chr6:111202823(+) A-I      intronic chr6:111201285(+) A-I      intronic chr6:111201339(+) A-I      intronic chr6:111207371(+) A-I      intronic chr6:111207882(+) A-I      intronic chr6:111207298(+) A-I      intronic chr6:111207338(+) A-I      intronic chr6:111201259(+) A-I      intronic chr6:111206751(+) A-I      intronic chr6:111207896(+) A-I      intronic chr6:111204189(+) A-I      intronic chr6:111205660(+) A-I      intronic chr6:111204216(+) A-I      intronic chr6:111207594(+) A-I      intronic chr6:111202863(+) A-I      intronic chr6:111207917(+) A-I      intronic chr6:111201976(+) A-I      intronic chr6:111206685(+) A-I      intronic chr6:111209792(+) A-I      intronic chr6:111203003(+) A-I      intronic chr6:111201918(+) A-I      intronic chr6:111207315(+) A-I      intronic chr6:111201252(+) A-I      intronic chr6:111205737(+) A-I      intronic chr6:111204179(+) A-I      intronic chr6:111202980(+) A-I      intronic chr6:111204262(+) A-I      intronic chr6:111202809(+) A-I      intronic chr6:111205656(+) A-I      intronic chr6:111202949(+) A-I      intronic chr6:111204854(+) A-I      intronic chr6:111206773(+) A-I      intronic chr6:111202934(+) A-I      intronic chr6:111201260(+) A-I      intronic chr6:111202893(+) A-I      intronic chr6:111200361(+) A-I      intronic chr6:111205766(+) A-I      intronic chr6:111207533(+) A-I      intronic chr6:111205007(+) A-I      intronic chr6:111207296(+) A-I      intronic chr6:111207910(+) A-I      intronic chr6:111207883(+) A-I      intronic chr6:111202948(+) A-I      intronic chr6:111205776(+) A-I      intronic chr6:111207877(+) A-I      intronic chr6:111204067(+) A-I      intronic chr6:111205655(+) A-I      intronic chr6:111207782(+) A-I      intronic chr6:111202056(+) A-I      intronic chr6:111202877(+) A-I      intronic chr6:111206734(+) A-I      intronic chr6:111207730(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AMD1	chr6:111201252(+) A-G intron -    22484847 chr6:111201259(+) A-G intron -    22484847 chr6:111201260(+) A-G intron -    22484847 chr6:111201339(+) A-G intron -    22484847 chr6:111202018(+) A-G intron -    22484847 chr6:111202934(+) A-G intron -    22484847 chr6:111202948(+) A-G intron -    22484847 chr6:111204112(+) A-G intron -    22484847 chr6:111204189(+) A-G intron -    22484847 chr6:111205007(+) A-G intron -    22484847 chr6:111205655(+) A-G intron -    22484847 chr6:111205656(+) A-G intron -    22484847 chr6:111205660(+) A-G intron -    22484847 chr6:111206696(+) A-G intron -    22484847 chr6:111207298(+) A-G intron -    22484847 chr6:111207594(+) A-G intron -    22484847 chr6:111207651(+) A-G intron -    22484847 chr6:111207692(+) A-G intron -    22484847 chr6:111207782(+) A-G intron -    22484847 chr6:111207877(+) A-G intron -    22484847 chr6:111212352(+) A-T intron -    22484847 chr6:111213046(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AMD1	chr6:111135888-111135889(+) m6A 5'UTR       - chr6:111135893-111135894(+) m6A 5'UTR       - chr6:111135902-111135903(+) m6A 5'UTR       - chr6:111135979-111135980(+) m6A 5'UTR       - chr6:111135992-111135993(+) m6A 5'UTR       - chr6:111179560-111179561(+) m6A intron       25456834 chr6:111179624-111179625(+) m6A intron       24284625//25456834 chr6:111179634-111179635(+) m6A intron       24284625//25456834 chr6:111179682-111179683(+) m6A intron       24284625//25456834 chr6:111179700-111179701(+) m6A intron       24284625//25456834 chr6:111179742-111179743(+) m6A intron       24284625//25456834 chr6:111179751-111179752(+) m6A intron       24284625//25456834 chr6:111179787-111179788(+) m6A intron       24284625//25456834 chr6:111179837-111179838(+) m6A intron       24284625//25456834 chr6:111179862-111179863(+) m6A intron       24284625//25456834 chr6:111179898-111179899(+) m6A intron       24284625//25456834 chr6:111180024-111180025(+) m6A intron       24284625//25456834 chr6:111180045-111180046(+) m6A intron       24284625//25456834 chr6:111180078-111180079(+) m6A intron       24284625 chr6:111180115-111180116(+) m6A intron       - chr6:111180138-111180139(+) m6A intron       - chr6:111196064-111196065(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr6:111196069-111196070(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr6:111196095-111196096(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr6:111196192-111196193(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085 chr6:111196198-111196199(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085 chr6:111196218-111196219(+) m6A 5'UTR//intron       24981863//26404942//22608085 chr6:111213567-111213568(+) Y CDS       25219674 chr6:111215181-111215182(+) m6A 3'UTR//exon       27773535 chr6:111215230-111215231(+) m6A 3'UTR//exon       27773535 chr6:111215665-111215666(+) m6A 3'UTR//exon       26404942 chr6:111215704-111215705(+) m6A 3'UTR//exon       26404942 chr6:111215714-111215715(+) m6A 3'UTR//exon       26404942 chr6:111216712-111216713(+) m6A 3'UTR//exon       27773535 chr6:111216732-111216733(+) m6A 3'UTR//exon       27773535 chr6:111216837-111216838(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	AMD1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART17-5p
Interactor2: AMD1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.