Basic Information:

  VIRBase ID:  

VHID00365029

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART16:  MIMAT0003714          EBPL:  NR_103803     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART16	EBPL
miRBase Accession/Entrez ID	MIMAT0003714	84650
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	EBRP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EBPL	chr13:50264042(-) A-I      intronic chr13:50263624(-) A-I      intronic chr13:50240907(-) A-I      intronic chr13:50263591(-) A-I      intronic chr13:50247028(-) A-I      intronic chr13:50264081(-) A-I      intronic chr13:50264075(-) A-I      intronic chr13:50240904(-) A-I      intronic chr13:50242588(-) A-I      NonSyn:Tyr->Cys chr13:50242520(-) A-I      NonSyn:Ser->Gly chr13:50242516(-) A-I      NonSyn:Gln->Arg chr13:50242653(-) A-I      Syn:Ser->Ser chr13:50242598(-) A-I      NonSyn:Ser->Gly chr13:50237022(-) A-I      intronic chr13:50237880(-) A-I      intronic chr13:50238271(-) A-I      intronic chr13:50238288(-) A-I      intronic chr13:50239349(-) A-I      intronic chr13:50239352(-) A-I      intronic chr13:50239379(-) A-I      intronic chr13:50239536(-) A-I      intronic chr13:50239564(-) A-I      intronic chr13:50239580(-) A-I      intronic chr13:50239582(-) A-I      intronic chr13:50239610(-) A-I      intronic chr13:50239722(-) A-I      intronic chr13:50239747(-) A-I      intronic chr13:50240603(-) A-I      intronic chr13:50240654(-) A-I      intronic chr13:50240667(-) A-I      intronic chr13:50240675(-) A-I      intronic chr13:50240726(-) A-I      intronic chr13:50240736(-) A-I      intronic chr13:50240748(-) A-I      intronic chr13:50240761(-) A-I      intronic chr13:50240821(-) A-I      intronic chr13:50240918(-) A-I      intronic chr13:50240968(-) A-I      intronic chr13:50243126(-) A-I      intronic chr13:50243127(-) A-I      intronic chr13:50243306(-) A-I      intronic chr13:50246962(-) A-I      intronic chr13:50247087(-) A-I      intronic chr13:50247746(-) A-I      intronic chr13:50247750(-) A-I      intronic chr13:50247774(-) A-I      intronic chr13:50253657(-) A-I      intronic chr13:50253811(-) A-I      intronic chr13:50253812(-) A-I      intronic chr13:50254809(-) A-I      intronic chr13:50254810(-) A-I      intronic chr13:50254871(-) A-I      intronic chr13:50254875(-) A-I      intronic chr13:50254876(-) A-I      intronic chr13:50254911(-) A-I      intronic chr13:50254935(-) A-I      intronic chr13:50255523(-) A-I      intronic chr13:50255535(-) A-I      intronic chr13:50255564(-) A-I      intronic chr13:50255591(-) A-I      intronic chr13:50255600(-) A-I      intronic chr13:50257178(-) A-I      intronic chr13:50257206(-) A-I      intronic chr13:50257215(-) A-I      intronic chr13:50257247(-) A-I      intronic chr13:50257499(-) A-I      intronic chr13:50262697(-) A-I      intronic chr13:50257610(-) A-I      intronic chr13:50239725(-) A-I      intronic chr13:50257474(-) A-I      intronic chr13:50257604(-) A-I      intronic chr13:50237045(-) A-I      intronic chr13:50239546(-) A-I      intronic chr13:50257213(-) A-I      intronic chr13:50259968(-) A-I      intronic chr13:50239442(-) A-I      intronic chr13:50239792(-) A-I      intronic chr13:50253072(-) A-I      intronic chr13:50253028(-) A-I      intronic chr13:50254716(-) A-I      intronic chr13:50255512(-) A-I      intronic chr13:50257618(-) A-I      intronic chr13:50239572(-) A-I      intronic chr13:50239583(-) A-I      intronic chr13:50254919(-) A-I      intronic chr13:50252999(-) A-I      intronic chr13:50255645(-) A-I      intronic chr13:50253066(-) A-I      intronic chr13:50259926(-) A-I      intronic chr13:50239680(-) A-I      intronic chr13:50258544(-) A-I      intronic chr13:50259900(-) A-I      intronic chr13:50247612(-) A-I      intronic chr13:50253730(-) A-I      intronic chr13:50263755(-) A-I      intronic chr13:50262836(-) A-I      intronic chr13:50253026(-) A-I      intronic chr13:50264164(-) A-I      intronic chr13:50257383(-) A-I      intronic chr13:50240917(-) A-I      intronic chr13:50259170(-) A-I      intronic chr13:50238205(-) A-I      intronic chr13:50239437(-) A-I      intronic chr13:50258615(-) A-I      intronic chr13:50258749(-) A-I      intronic chr13:50259104(-) A-I      intronic chr13:50259887(-) A-I      intronic chr13:50259923(-) A-I      intronic chr13:50261034(-) A-I      intronic chr13:50261046(-) A-I      intronic chr13:50261056(-) A-I      intronic chr13:50261096(-) A-I      intronic chr13:50262669(-) A-I      intronic chr13:50262733(-) A-I      intronic chr13:50263704(-) A-I      intronic chr13:50264056(-) A-I      intronic chr13:50264083(-) A-I      intronic chr13:50264113(-) A-I      intronic chr13:50264205(-) A-I      intronic chr13:50242466(-) A-I      3'UTR chr13:50242634(-) A-I      NonSyn:Arg->Gly chr13:50241884(-) A-I      intronic chr13:50248328(-) A-I      intronic chr13:50248331(-) A-I      intronic chr13:50239761(-) A-I      intronic chr13:50238279(-) A-I      intronic chr13:50239746(-) A-I      intronic chr13:50261123(-) A-I      intronic chr13:50239721(-) A-I      intronic chr13:50240944(-) A-I      intronic chr13:50247710(-) A-I      intronic chr13:50264199(-) A-I      intronic chr13:50240684(-) A-I      intronic chr13:50259102(-) A-I      intronic chr13:50253806(-) A-I      intronic chr13:50254914(-) A-I      intronic chr13:50263649(-) A-I      intronic chr13:50258728(-) A-I      intronic chr13:50238185(-) A-I      intronic chr13:50238225(-) A-I      intronic chr13:50260967(-) A-I      intronic chr13:50259952(-) A-I      intronic chr13:50239259(-) A-I      intronic chr13:50255487(-) A-I      intronic chr13:50258602(-) A-I      intronic chr13:50243475(-) A-I      intronic chr13:50259776(-) A-I      intronic chr13:50247705(-) A-I      intronic chr13:50240076(-) A-I      intronic chr13:50258683(-) A-I      intronic chr13:50253782(-) A-I      intronic chr13:50247671(-) A-I      intronic chr13:50264103(-) A-I      intronic chr13:50259922(-) A-I      intronic chr13:50257315(-) A-I      intronic chr13:50247113(-) A-I      intronic chr13:50247776(-) A-I      intronic chr13:50250538(-) A-I      intronic chr13:50239679(-) A-I      intronic chr13:50258699(-) A-I      intronic chr13:50257567(-) A-I      intronic chr13:50246939(-) A-I      intronic chr13:50247148(-) A-I      intronic chr13:50254778(-) A-I      intronic chr13:50238305(-) A-I      intronic chr13:50254823(-) A-I      intronic chr13:50240644(-) A-I      intronic chr13:50240939(-) A-I      intronic chr13:50236227(-) A-I      intronic chr13:50240926(-) A-I      intronic chr13:50258785(-) A-I      intronic chr13:50255700(-) A-I      intronic chr13:50254715(-) A-I      intronic chr13:50238383(-) A-I      intronic chr13:50239702(-) A-I      intronic chr13:50253766(-) A-I      intronic chr13:50259118(-) A-I      intronic chr13:50239796(-) A-I      intronic chr13:50255646(-) A-I      intronic chr13:50257580(-) A-I      intronic chr13:50240943(-) A-I      intronic chr13:50258604(-) A-I      intronic chr13:50259166(-) A-I      intronic chr13:50247037(-) A-I      intronic chr13:50257384(-) A-I      intronic chr13:50254872(-) A-I      intronic chr13:50239545(-) A-I      intronic chr13:50261218(-) A-I      intronic chr13:50257314(-) A-I      intronic chr13:50257280(-) A-I      intronic chr13:50239385(-) A-I      intronic chr13:50237900(-) A-I      intronic chr13:50240601(-) A-I      intronic chr13:50240659(-) A-I      intronic chr13:50255532(-) A-I      intronic chr13:50263583(-) A-I      intronic chr13:50247114(-) A-I      intronic chr13:50254836(-) A-I      intronic chr13:50240914(-) A-I      intronic chr13:50239736(-) A-I      intronic chr13:50247149(-) A-I      intronic chr13:50245346(-) A-I      intronic chr13:50247683(-) A-I      intronic chr13:50241816(-) A-I      intronic chr13:50243154(-) A-I      intronic chr13:50263582(-) A-I      intronic chr13:50264074(-) A-I      intronic chr13:50248316(-) A-I      intronic chr13:50257657(-) A-I      intronic chr13:50247678(-) A-I      intronic chr13:50259754(-) A-I      intronic chr13:50261142(-) A-I      intronic chr13:50263626(-) A-I      intronic chr13:50259193(-) A-I      intronic chr13:50258759(-) A-I      intronic chr13:50254792(-) A-I      intronic chr13:50238376(-) A-I      intronic chr13:50253918(-) A-I      intronic chr13:50239411(-) A-I      intronic chr13:50241904(-) A-I      intronic chr13:50264120(-) A-I      intronic chr13:50239737(-) A-I      intronic chr13:50240973(-) A-I      intronic chr13:50264273(-) A-I      intronic chr13:50264204(-) A-I      intronic chr13:50239475(-) A-I      intronic chr13:50259153(-) A-I      intronic chr13:50237829(-) A-I      intronic chr13:50239548(-) A-I      intronic chr13:50253778(-) A-I      intronic chr13:50253894(-) A-I      intronic chr13:50247853(-) A-I      intronic chr13:50264041(-) A-I      intronic chr13:50264174(-) A-I      intronic chr13:50239666(-) A-I      intronic chr13:50264278(-) A-I      intronic chr13:50263614(-) A-I      intronic chr13:50264123(-) A-I      intronic chr13:50239332(-) A-I      intronic chr13:50241894(-) A-I      intronic chr13:50245341(-) A-I      intronic chr13:50250493(-) A-I      intronic chr13:50243367(-) A-I      intronic chr13:50247609(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EBPL	chr13:50239385(-) A-G intron -    22484847 chr13:50239548(-) A-G intron -    22484847 chr13:50239796(-) A-G intron -    22484847 chr13:50253066(-) A-G intron -    22484847 chr13:50262621(-) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EBPL	chr13:50234995-50234996(-) Y 3'UTR//exon       26075521 chr13:50235064-50235065(-) m6A 3'UTR//exon       24981863 chr13:50235086-50235087(-) m6A 3'UTR//exon       24981863 chr13:50235093-50235094(-) m6A 3'UTR//exon       24981863 chr13:50235102-50235103(-) m6A 3'UTR//exon       24981863 chr13:50235129-50235130(-) m6A 3'UTR//CDS//exon       24981863 chr13:50235154-50235155(-) m6A 3'UTR//CDS//exon       24981863 chr13:50235181-50235182(-) m6A 3'UTR//CDS//exon       24981863 chr13:50260715-50260716(-) m6A exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EBPL	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART16
Interactor2: EBPL

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.