Basic Information:

  VIRBase ID:  

VHID00364466

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART16:  MIMAT0003714          ZNF512B:  NM_020713     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART16	ZNF512B
miRBase Accession/Entrez ID	MIMAT0003714	57473
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GM632

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF512B	chr20:62639160(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF512B	chr20:62588617-62588618(-) m6A 3'UTR       - chr20:62589383-62589384(-) m6A 3'UTR       24284625//27371828//27773536 chr20:62589389-62589390(-) m6A 3'UTR       24284625//27371828//27773536 chr20:62589477-62589478(-) m6A 3'UTR       27371828 chr20:62590142-62590143(-) m6A 3'UTR       24284625 chr20:62590360-62590361(-) m6A 3'UTR       24981863 chr20:62590547-62590548(-) Y 3'UTR       26075521 chr20:62590729-62590730(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27773536//22608085 chr20:62590757-62590758(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27773536//22575960//22608085 chr20:62591167-62591168(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27371828//27773536//22608085 chr20:62591301-62591302(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr20:62591365-62591366(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr20:62591442-62591443(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr20:62591456-62591457(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr20:62591469-62591470(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr20:62591479-62591480(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr20:62592672-62592673(-) m6A CDS       24284625//25456834//27773535//27371828//27773536//22608085 chr20:62593324-62593325(-) m6A CDS       22575960 chr20:62593662-62593663(-) Am CDS       - chr20:62593692-62593693(-) m6A CDS       27371828//27773536 chr20:62593947-62593948(-) m6A CDS       27371828//27773536 chr20:62593983-62593984(-) m6A CDS       24284625//27371828//27773536 chr20:62594073-62594074(-) m6A CDS       24284625//27371828//27773536 chr20:62594093-62594094(-) m6A CDS       24284625//27371828//27773536 chr20:62594114-62594115(-) m6A CDS       24284625//27371828//27773536 chr20:62594538-62594539(-) m6A CDS       24284625//27371828//27773536 chr20:62595182-62595183(-) m6A CDS       27371828//27773536 chr20:62595551-62595552(-) m6A CDS       24284625//27371828//27773536 chr20:62595687-62595688(-) m6A CDS       24284625//27371828//27773536 chr20:62595729-62595730(-) m6A CDS       24284625//27371828//27773536 chr20:62595736-62595737(-) m6A CDS       24284625//27371828//27773536 chr20:62595862-62595863(-) m6A CDS       24284625//27371828//27773536 chr20:62595955-62595956(-) m6A CDS       24284625//27371828//27773536 chr20:62596051-62596052(-) m6A CDS       24284625//22575960 chr20:62596060-62596061(-) m6A CDS       22575960 chr20:62597508-62597509(-) m6A CDS       22575960 chr20:62597535-62597536(-) m6A CDS       22575960 chr20:62597813-62597814(-) m6A CDS       24284625 chr20:62597867-62597868(-) m6A CDS       24284625 chr20:62597903-62597904(-) m6A CDS       24284625 chr20:62597921-62597922(-) m6A CDS       24284625 chr20:62597939-62597940(-) m6A CDS       24284625 chr20:62598033-62598034(-) m6A CDS       24284625 chr20:62598042-62598043(-) m6A CDS       24284625 chr20:62598056-62598057(-) m6A CDS       24284625 chr20:62598070-62598071(-) m6A CDS       24284625 chr20:62598295-62598296(-) m6A CDS       24284625 chr20:62598329-62598330(-) Gm CDS       - chr20:62598740-62598741(-) m6A CDS       24284625//27371828 chr20:62598755-62598756(-) m6A CDS       24284625//27371828 chr20:62598792-62598793(-) m6A CDS       24284625//27371828 chr20:62598849-62598850(-) m6A CDS       - chr20:62598853-62598854(-) m6A CDS       24284625 chr20:62605681-62605682(-) m6A intron       27773535 chr20:62605728-62605729(-) m6A intron       24284625//27773535 chr20:62605767-62605768(-) m6A intron       24284625//27773535 chr20:62605816-62605817(-) m6A intron       24284625 chr20:62606167-62606168(-) m6A intron       27773535 chr20:62606188-62606189(-) m6A intron       27773535 chr20:62606211-62606212(-) m6A intron       27773535 chr20:62606537-62606538(-) m6A intron       - chr20:62606560-62606561(-) m6A intron       - chr20:62606623-62606624(-) m6A intron       - chr20:62606690-62606691(-) m6A intron       25456834//27371828 chr20:62606723-62606724(-) m6A intron       24284625//25456834//27371828 chr20:62606732-62606733(-) m6A intron       24284625//25456834//27371828 chr20:62606771-62606772(-) m6A intron       24284625//25456834//27371828 chr20:62606838-62606839(-) m6A intron       24284625//25456834//27371828 chr20:62606844-62606845(-) m6A intron       24284625//25456834//27371828 chr20:62608587-62608588(-) m6A intron       24284625//27371828 chr20:62608678-62608679(-) m6A intron       24284625//27371828//27773536 chr20:62608732-62608733(-) m6A intron       24284625//27371828 chr20:62609602-62609603(-) m6A intron       27371828 chr20:62609630-62609631(-) m6A intron       27371828 chr20:62611255-62611256(-) m6A intron       27371828 chr20:62611355-62611356(-) m6A intron       27371828 chr20:62679620-62679621(-) m6A intron       24284625//25456834//24981863 chr20:62679667-62679668(-) m6A intron       24284625//25456834//24981863 chr20:62679705-62679706(-) m6A intron       25456834//24981863 chr20:62679859-62679860(-) m6A intron       24209618//25456834//22575960 chr20:62679903-62679904(-) m6A intron       24209618//25456834//22575960 chr20:62679957-62679958(-) m6A intron       24209618//25456834//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF512B	Chromatin K562 cells     - Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm HeLa-S3 cells|K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART16
Interactor2: ZNF512B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.