Detail Information

Basic Information:


  VIRBase ID:  

VHID00363176

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART16:           NME6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART16 NME6
miRBase
Accession/Entrez ID		 MIMAT0003714 10201
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - IPIA-ALPHA//NDK 6//NM23-H6

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NME6
chr3:48337047(-) A-I      intronic
chr3:48337295(-) A-I      intronic
chr3:48342294(-) A-I      intronic
chr3:48342452(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NME6
chr3:48342294(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NME6
chr3:48334755-48334756(-) m6A 3'UTR       24981863//22608085
chr3:48334783-48334784(-) m6A 3'UTR       24981863//22608085
chr3:48334792-48334793(-) m6A 3'UTR       24981863//22608085
chr3:48334801-48334802(-) m6A 3'UTR       24981863//22608085
chr3:48334815-48334816(-) m6A 3'UTR       24981863//22608085
chr3:48334866-48334867(-) m6A 3'UTR       22608085
chr3:48335245-48335246(-) m6A 3'UTR       27773535
chr3:48335274-48335275(-) m6A 3'UTR       27773535
chr3:48335304-48335305(-) m6A 3'UTR       27773535
chr3:48335393-48335394(-) m6A 3'UTR       27773535//22608085
chr3:48335456-48335457(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr3:48335530-48335531(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085
chr3:48335660-48335661(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr3:48335756-48335757(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr3:48335779-48335780(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr3:48335893-48335894(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr3:48336010-48336011(-) Y 3'UTR//exon       26075521
chr3:48336054-48336055(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:48336067-48336068(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:48336081-48336082(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:48336092-48336093(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:48336110-48336111(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:48336135-48336136(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:48336149-48336150(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr3:48336237-48336238(-) m6A 3'UTR//CDS//exon       24284625//27371828
chr3:48338256-48338257(-) Gm CDS//exon//intron       -
chr3:48339331-48339332(-) m6A exon//intron       25456834
chr3:48339393-48339394(-) m6A exon//intron       25456834
chr3:48339431-48339432(-) m6A exon//intron       25456834
chr3:48339475-48339476(-) m6A exon//intron       25456834
chr3:48341875-48341876(-) m6A 5'UTR//intron       27773535
chr3:48341884-48341885(-) m6A 5'UTR//intron       27773535
chr3:48342942-48342943(-) m6A 5'UTR       24981863
chr3:48342948-48342949(-) m6A 5'UTR       24981863
chr3:48343002-48343003(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate NME6
Chromatin K562 cells     -
Exosome Blood     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART16
Interactor2: NME6

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

Starting a new search, please wait ...