Detail Information

Basic Information:


  VIRBase ID:  

VHID00361085

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART15:           ATXN1L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART15 ATXN1L
miRBase
Accession/Entrez ID		 MIMAT0003713 342371
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BOAT//BOAT1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ATXN1L
chr16:71892629(+) A-I      intronic
chr16:71892635(+) A-I      intronic
chr16:71892610(+) A-I      intronic
chr16:71907766(+) A-I      intronic
chr16:71892567(+) A-I      intronic
chr16:71892007(+) A-I      intronic
chr16:71892283(+) A-I      intronic
chr16:71892296(+) A-I      intronic
chr16:71892075(+) A-I      intronic
chr16:71892290(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ATXN1L
chr16:71892251(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ATXN1L
chr16:71881933-71881934(+) m6A 5'UTR//exon       24284625
chr16:71881968-71881969(+) m6A 5'UTR//exon       24284625
chr16:71882035-71882036(+) m6A exon//intron       24284625//24981863
chr16:71882040-71882041(+) m6A exon//intron       24284625//24981863
chr16:71882298-71882299(+) m6A exon//intron       -
chr16:71883628-71883629(+) m6A 5'UTR//intron       24284625//24209618
chr16:71883648-71883649(+) m6A CDS//intron       24284625//24209618
chr16:71883695-71883696(+) m6A CDS//intron       24284625//24209618//24981863
chr16:71883727-71883728(+) m6A CDS//intron       24284625//24209618//24981863
chr16:71883872-71883873(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71883930-71883931(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr16:71884304-71884305(+) m6A CDS//intron       24284625//24209618//24981863
chr16:71884375-71884376(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr16:71884455-71884456(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:71884461-71884462(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:71884536-71884537(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr16:71884569-71884570(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr16:71884591-71884592(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71884630-71884631(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71884637-71884638(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71884685-71884686(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71884719-71884720(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71884787-71884788(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71884848-71884849(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr16:71884857-71884858(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr16:71884863-71884864(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr16:71884915-71884916(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr16:71884997-71884998(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71885102-71885103(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71885110-71885111(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71885177-71885178(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71885399-71885400(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr16:71885502-71885503(+) Cm CDS//intron       -
chr16:71885713-71885714(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr16:71885726-71885727(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr16:71885732-71885733(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr16:71885903-71885904(+) m6A 3'UTR//intron       24284625
chr16:71886204-71886205(+) m6A 3'UTR//intron       -
chr16:71888680-71888681(+) m6A 3'UTR//intron       -
chr16:71888736-71888737(+) m6A 3'UTR//intron       -
chr16:71889482-71889483(+) m6A 3'UTR//intron       24981863
chr16:71889541-71889542(+) m6A 3'UTR//intron       24981863//27773535
chr16:71893696-71893697(+) m6A intron       -
chr16:71893796-71893797(+) m6A intron       -
chr16:71893822-71893823(+) m6A intron       -
chr16:71894060-71894061(+) m6A intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ATXN1L
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART15
Interactor2: ATXN1L

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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