Detail Information

Basic Information:


  VIRBase ID:  

VHID00358819

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART15:           ZFYVE26:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART15 ZFYVE26
miRBase
Accession/Entrez ID		 MIMAT0003713 23503
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - FYVE-CENT//SPG15

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZFYVE26
chr14:68225522(-) A-I      intronic
chr14:68199390(-) A-I      intronic
chr14:68227411(-) A-I      intronic
chr14:68209771(-) A-I      intronic
chr14:68199431(-) A-I      intronic
chr14:68227414(-) A-I      intronic
chr14:68209725(-) A-I      intronic
chr14:68199383(-) A-I      intronic
chr14:68225521(-) A-I      intronic
chr14:68209753(-) A-I      intronic
chr14:68199399(-) A-I      intronic
chr14:68203847(-) A-I      intronic
chr14:68225789(-) A-I      intronic
chr14:68224635(-) A-I      intronic
chr14:68199554(-) A-I      intronic
chr14:68209961(-) A-I      intronic
chr14:68210096(-) A-I      intronic
chr14:68226078(-) A-I      intronic
chr14:68198627(-) A-I      intronic
chr14:68198761(-) A-I      intronic
chr14:68246157(-) A-I      intronic
chr14:68224630(-) A-I      intronic
chr14:68226315(-) A-I      intronic
chr14:68198762(-) A-I      intronic
chr14:68225425(-) A-I      intronic
chr14:68225850(-) A-I      intronic
chr14:68209733(-) A-I      intronic
chr14:68225918(-) A-I      intronic
chr14:68225838(-) A-I      intronic
chr14:68224696(-) A-I      intronic
chr14:68246769(-) A-I      intronic
chr14:68209805(-) A-I      intronic
chr14:68227350(-) A-I      intronic
chr14:68246171(-) A-I      intronic
chr14:68225547(-) A-I      intronic
chr14:68246233(-) A-I      intronic
chr14:68224570(-) A-I      intronic
chr14:68225438(-) A-I      intronic
chr14:68226192(-) A-I      intronic
chr14:68224547(-) A-I      intronic
chr14:68225491(-) A-I      intronic
chr14:68199321(-) A-I      intronic
chr14:68226178(-) A-I      intronic
chr14:68225501(-) A-I      intronic
chr14:68246649(-) A-I      intronic
chr14:68224524(-) A-I      intronic
chr14:68199438(-) A-I      intronic
chr14:68246277(-) A-I      intronic
chr14:68246296(-) A-I      intronic
chr14:68225598(-) A-I      intronic
chr14:68246284(-) A-I      intronic
chr14:68226281(-) A-I      intronic
chr14:68246760(-) A-I      intronic
chr14:68224499(-) A-I      intronic
chr14:68212563(-) A-I      intronic
chr14:68261622(-) A-I      intronic
chr14:68225558(-) A-I      intronic
chr14:68225792(-) A-I      intronic
chr14:68198069(-) A-I      intronic
chr14:68261660(-) A-I      intronic
chr14:68198043(-) A-I      intronic
chr14:68197999(-) A-I      intronic
chr14:68197997(-) A-I      intronic
chr14:68269838(-) A-I      intronic
chr14:68209571(-) A-I      intronic
chr14:68204559(-) A-I      intronic
chr14:68227388(-) A-I      intronic
chr14:68199498(-) A-I      intronic
chr14:68226175(-) A-I      intronic
chr14:68246155(-) A-I      intronic
chr14:68210002(-) A-I      intronic
chr14:68259517(-) A-I      intronic
chr14:68269902(-) A-I      intronic
chr14:68209624(-) A-I      intronic
chr14:68226257(-) A-I      intronic
chr14:68246167(-) A-I      intronic
chr14:68225767(-) A-I      intronic
chr14:68225517(-) A-I      intronic
chr14:68225485(-) A-I      intronic
chr14:68220946(-) A-I      intronic
chr14:68225631(-) A-I      intronic
chr14:68246240(-) A-I      intronic
chr14:68209730(-) A-I      intronic
chr14:68209685(-) A-I      intronic
chr14:68209787(-) A-I      intronic
chr14:68198626(-) A-I      intronic
chr14:68246123(-) A-I      intronic
chr14:68225520(-) A-I      intronic
chr14:68227369(-) A-I      intronic
chr14:68246290(-) A-I      intronic
chr14:68204978(-) A-I      intronic
chr14:68246768(-) A-I      intronic
chr14:68210145(-) A-I      intronic
chr14:68246727(-) A-I      intronic
chr14:68209729(-) A-I      intronic
chr14:68224469(-) A-I      intronic
chr14:68209642(-) A-I      intronic
chr14:68203864(-) A-I      intronic
chr14:68225846(-) A-I      intronic
chr14:68209829(-) A-I      intronic
chr14:68203817(-) A-I      intronic
chr14:68225490(-) A-I      intronic
chr14:68225608(-) A-I      intronic
chr14:68210073(-) A-I      intronic
chr14:68226289(-) A-I      intronic
chr14:68199386(-) A-I      intronic
chr14:68273805(-) A-I      intronic
chr14:68225837(-) A-I      intronic
chr14:68209721(-) A-I      intronic
chr14:68225840(-) A-I      intronic
chr14:68259384(-) A-I      intronic
chr14:68225557(-) A-I      intronic
chr14:68209754(-) A-I      intronic
chr14:68225712(-) A-I      intronic
chr14:68210125(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZFYVE26
chr14:68262981(-) A-I intron -    15342557
chr14:68262986(-) A-I intron -    15342557
chr14:68263036(-) A-I intron -    15342557
chr14:68263039(-) A-I intron -    15342557
chr14:68263045(-) A-I intron -    15342557
chr14:68263091(-) A-I intron -    15342557
chr14:68263099(-) A-I intron -    15342557
chr14:68263100(-) A-I intron -    15342557
chr14:68263101(-) A-I intron -    15342557
chr14:68263105(-) A-I intron -    15342557
chr14:68263116(-) A-I intron -    15342557
chr14:68263118(-) A-I intron -    15342557
chr14:68263122(-) A-I intron -    15342557
chr14:68263126(-) A-I intron -    15342557
chr14:68263136(-) A-I intron -    15342557
chr14:68263150(-) A-I intron -    15342557
chr14:68263155(-) A-I intron -    15342557
chr14:68263169(-) A-I intron -    15342557
chr14:68263202(-) A-I intron -    15342557
chr14:68263424(-) A-I intron -    15342557
chr14:68263425(-) A-I intron -    15342557
chr14:68263477(-) A-I intron -    15342557
chr14:68263486(-) A-I intron -    15342557
chr14:68263503(-) A-I intron -    15342557
chr14:68263506(-) A-I intron -    15342557
chr14:68263582(-) A-I intron -    15342557
chr14:68263583(-) A-I intron -    15342557
chr14:68263617(-) A-I intron -    15342557
chr14:68263643(-) A-I intron -    15342557
chr14:68225520(-) A-G intron -    22484847
chr14:68263202(-) A-G intron -    22484847
chr14:68263583(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFYVE26
chr14:68213267-68213268(-) m6A 3'UTR//intron       27773535
chr14:68213306-68213307(-) m6A 3'UTR//intron       27773535
chr14:68213317-68213318(-) m6A 3'UTR//intron       27773535
chr14:68213345-68213346(-) m6A 3'UTR//intron       27773535
chr14:68213376-68213377(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213406-68213407(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213442-68213443(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213499-68213500(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213617-68213618(-) m6A 3'UTR//intron       24981863
chr14:68213625-68213626(-) m6A 3'UTR//intron       24981863
chr14:68213636-68213637(-) m6A 3'UTR//intron       24981863
chr14:68214988-68214989(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27773535//27371828//22608085
chr14:68215018-68215019(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27773535//27371828//22608085
chr14:68215059-68215060(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr14:68215130-68215131(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr14:68215219-68215220(-) m6A 3'UTR//CDS//exon//intron       24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr14:68215293-68215294(-) m6A 3'UTR//CDS//exon//intron       27773535//22608085
chr14:68215329-68215330(-) m6A 3'UTR//CDS//exon//intron       27773535
chr14:68227932-68227933(-) m6A 3'UTR//intron       24284625//27773535//22608085
chr14:68227939-68227940(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr14:68228006-68228007(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228026-68228027(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228070-68228071(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228076-68228077(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228203-68228204(-) m6A 3'UTR//CDS//exon       27773535
chr14:68228268-68228269(-) m6A 3'UTR//CDS//exon       27773535
chr14:68241780-68241781(-) m6A 3'UTR//CDS//exon       -
chr14:68244329-68244330(-) m6A 3'UTR//CDS//exon       27773535
chr14:68244914-68244915(-) m6A 3'UTR//CDS//exon       27773535
chr14:68249785-68249786(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22608085
chr14:68249854-68249855(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:68249875-68249876(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:68249987-68249988(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr14:68250026-68250027(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr14:68250036-68250037(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr14:68250132-68250133(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535
chr14:68251849-68251850(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251878-68251879(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251888-68251889(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251907-68251908(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251985-68251986(-) m6A 3'UTR//CDS//exon       24284625//27773536
chr14:68262985-68262986(-) m6A exon//intron       24981863
chr14:68264406-68264407(-) m6A 3'UTR//CDS//exon       27371828//27773536
chr14:68264761-68264762(-) m6A 3'UTR//CDS//exon       27371828//27773536
chr14:68264815-68264816(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22608085
chr14:68264971-68264972(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:68264978-68264979(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:68265014-68265015(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr14:68265060-68265061(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr14:68265185-68265186(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr14:68265248-68265249(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr14:68268842-68268843(-) m6A CDS//exon//intron       27773535
chr14:68268857-68268858(-) m6A CDS//exon//intron       27773535
chr14:68268866-68268867(-) m6A CDS//exon//intron       27773535
chr14:68268893-68268894(-) m6A CDS//exon//intron       27773535
chr14:68274255-68274256(-) m6A CDS//exon       25456834//27773536//22608085
chr14:68274274-68274275(-) m6A CDS//exon       25456834//24981863//27773536//22608085
chr14:68274310-68274311(-) m6A CDS//exon       25456834//24981863//27371828//27773536//22608085
chr14:68274330-68274331(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr14:68274416-68274417(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr14:68282742-68282743(-) m6A 5'UTR//exon       24981863
chr14:68283294-68283295(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZFYVE26
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART15
Interactor2: ZFYVE26

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.
[2]PMID 22291592 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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