Basic Information:

  VIRBase ID:  

VHID00358649

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART15:  MIMAT0003713          STK38L:  NM_015000     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART15	STK38L
miRBase Accession/Entrez ID	MIMAT0003713	23012
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	NDR2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STK38L	chr12:27465011(+) A-I      intronic chr12:27464952(+) A-I      intronic chr12:27464913(+) A-I      intronic chr12:27428410(+) A-I      intronic chr12:27467187(+) A-I      intronic chr12:27467223(+) A-I      intronic chr12:27466501(+) A-I      intronic chr12:27467245(+) A-I      intronic chr12:27467255(+) A-I      intronic chr12:27424813(+) A-I      intronic chr12:27426941(+) A-I      intronic chr12:27465965(+) A-I      intronic chr12:27427065(+) A-I      intronic chr12:27428346(+) A-I      intronic chr12:27428377(+) A-I      intronic chr12:27428396(+) A-I      intronic chr12:27454317(+) A-I      intronic chr12:27454318(+) A-I      intronic chr12:27454321(+) A-I      intronic chr12:27427059(+) A-I      intronic chr12:27454322(+) A-I      intronic chr12:27454394(+) A-I      intronic chr12:27454400(+) A-I      intronic chr12:27454405(+) A-I      intronic chr12:27454454(+) A-I      intronic chr12:27455734(+) A-I      intronic chr12:27455784(+) A-I      intronic chr12:27455803(+) A-I      intronic chr12:27455839(+) A-I      intronic chr12:27456931(+) A-I      intronic chr12:27456993(+) A-I      intronic chr12:27465927(+) A-I      intronic chr12:27466030(+) A-I      intronic chr12:27466536(+) A-I      intronic chr12:27466551(+) A-I      intronic chr12:27467079(+) A-I      intronic chr12:27467105(+) A-I      intronic chr12:27467109(+) A-I      intronic chr12:27467120(+) A-I      intronic chr12:27467148(+) A-I      intronic chr12:27415985(+) A-I      intronic chr12:27415534(+) A-I      intronic chr12:27467299(+) A-I      intronic chr12:27467305(+) A-I      intronic chr12:27415540(+) A-I      intronic chr12:27415571(+) A-I      intronic chr12:27415633(+) A-I      intronic chr12:27415763(+) A-I      intronic chr12:27415871(+) A-I      intronic chr12:27415958(+) A-I      intronic chr12:27466389(+) A-I      intronic chr12:27422715(+) A-I      intronic chr12:27422845(+) A-I      intronic chr12:27422856(+) A-I      intronic chr12:27423540(+) A-I      intronic chr12:27424694(+) A-I      intronic chr12:27424762(+) A-I      intronic chr12:27424772(+) A-I      intronic chr12:27465997(+) A-I      intronic chr12:27428453(+) A-I      intronic chr12:27466392(+) A-I      intronic chr12:27440132(+) A-I      intronic chr12:27441067(+) A-I      intronic chr12:27466358(+) A-I      intronic chr12:27457107(+) A-I      intronic chr12:27459861(+) A-I      intronic chr12:27447203(+) A-I      intronic chr12:27415831(+) A-I      intronic chr12:27466018(+) A-I      intronic chr12:27466060(+) A-I      intronic chr12:27415836(+) A-I      intronic chr12:27451200(+) A-I      intronic chr12:27415511(+) A-I      intronic chr12:27440998(+) A-I      intronic chr12:27466464(+) A-I      intronic chr12:27447768(+) A-I      intronic chr12:27455685(+) A-I      intronic chr12:27447773(+) A-I      intronic chr12:27457013(+) A-I      intronic chr12:27428456(+) A-I      intronic chr12:27454331(+) A-I      intronic chr12:27415817(+) A-I      intronic chr12:27466590(+) A-I      intronic chr12:27457007(+) A-I      intronic chr12:27466454(+) A-I      intronic chr12:27451265(+) A-I      intronic chr12:27451133(+) A-I      intronic chr12:27447901(+) A-I      intronic chr12:27466499(+) A-I      intronic chr12:27415531(+) A-I      intronic chr12:27467133(+) A-I      intronic chr12:27415587(+) A-I      intronic chr12:27447365(+) A-I      intronic chr12:27466481(+) A-I      intronic chr12:27451261(+) A-I      intronic chr12:27465918(+) A-I      intronic chr12:27466513(+) A-I      intronic chr12:27473261(+) A-I      intronic chr12:27467213(+) A-I      intronic chr12:27424822(+) A-I      intronic chr12:27420300(+) A-I      intronic chr12:27428452(+) A-I      intronic chr12:27415783(+) A-I      intronic chr12:27459864(+) A-I      intronic chr12:27422797(+) A-I      intronic chr12:27466027(+) A-I      intronic chr12:27415832(+) A-I      intronic chr12:27466480(+) A-I      intronic chr12:27403785(+) A-I      intronic chr12:27447710(+) A-I      intronic chr12:27464877(+) A-I      intronic chr12:27456933(+) A-I      intronic chr12:27457112(+) A-I      intronic chr12:27466588(+) A-I      intronic chr12:27466021(+) A-I      intronic chr12:27454461(+) A-I      intronic chr12:27428381(+) A-I      intronic chr12:27415563(+) A-I      intronic chr12:27447877(+) A-I      intronic chr12:27428546(+) A-I      intronic chr12:27457017(+) A-I      intronic chr12:27467259(+) A-I      intronic chr12:27464997(+) A-I      intronic chr12:27467244(+) A-I      intronic chr12:27415553(+) A-I      intronic chr12:27459774(+) A-I      intronic chr12:27466319(+) A-I      intronic chr12:27467275(+) A-I      intronic chr12:27415782(+) A-I      intronic chr12:27447191(+) A-I      intronic chr12:27467100(+) A-I      intronic chr12:27424816(+) A-I      intronic chr12:27451146(+) A-I      intronic chr12:27466568(+) A-I      intronic chr12:27451225(+) A-I      intronic chr12:27466444(+) A-I      intronic chr12:27466070(+) A-I      intronic chr12:27459697(+) A-I      intronic chr12:27466456(+) A-I      intronic chr12:27451330(+) A-I      intronic chr12:27415495(+) A-I      intronic chr12:27447180(+) A-I      intronic chr12:27466126(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STK38L	chr12:27451133(+) A-I intron -    15258596 chr12:27451146(+) A-I intron -    15258596 chr12:27451200(+) A-I intron -    15258596 chr12:27476394(+) T-G intron -    21725310 chr12:27478128(+) A-C intron -    21725310 chr12:27415563(+) A-G intron -    22484847 chr12:27466027(+) A-G intron -    22484847 chr12:27466060(+) A-G intron -    22484847 chr12:27466126(+) A-G intron -    22484847 chr12:27466358(+) A-G intron -    22484847 chr12:27466454(+) A-G intron -    22484847 chr12:27467259(+) A-G intron -    22484847 chr12:27467275(+) A-G intron -    22484847 chr12:27400768(+) G-T intron -    22484847 chr12:27403785(+) A-G intron -    22484847 chr12:27403950(+) G-A intron -    22484847 chr12:27415495(+) A-G intron -    22484847 chr12:27415511(+) A-G intron -    22484847 chr12:27415531(+) A-G intron -    22484847 chr12:27415553(+) A-G intron -    22484847 chr12:27415587(+) A-G intron -    22484847 chr12:27415783(+) A-G intron -    22484847 chr12:27415817(+) A-G intron -    22484847 chr12:27415831(+) A-G intron -    22484847 chr12:27415832(+) A-G intron -    22484847 chr12:27415877(+) G-A intron -    22484847 chr12:27422797(+) A-G intron -    22484847 chr12:27424816(+) A-G intron -    22484847 chr12:27424822(+) A-G intron -    22484847 chr12:27426943(+) C-T intron -    22484847 chr12:27428452(+) A-G intron -    22484847 chr12:27428453(+) A-G intron -    22484847 chr12:27428456(+) A-G intron -    22484847 chr12:27447174(+) T-C intron -    22484847 chr12:27447180(+) A-G intron -    22484847 chr12:27447203(+) A-G intron -    22484847 chr12:27447365(+) A-G intron -    22484847 chr12:27447901(+) A-G intron -    22484847 chr12:27451225(+) A-G intron -    22484847 chr12:27451265(+) A-G intron -    22484847 chr12:27454331(+) A-G intron -    22484847 chr12:27454461(+) A-G intron -    22484847 chr12:27459692(+) T-A intron -    22484847 chr12:27464877(+) A-G intron -    22484847 chr12:27464997(+) A-G intron -    22484847 chr12:27465918(+) A-G intron -    22484847 chr12:27465992(+) T-C intron -    22484847 chr12:27465997(+) A-G intron -    22484847 chr12:27466018(+) A-G intron -    22484847 chr12:27466021(+) A-G intron -    22484847 chr12:27466070(+) A-G intron -    22484847 chr12:27466392(+) A-G intron -    22484847 chr12:27466456(+) A-G intron -    22484847 chr12:27466464(+) A-G intron -    22484847 chr12:27466481(+) A-G intron -    22484847 chr12:27466499(+) A-G intron -    22484847 chr12:27466513(+) A-G intron -    22484847 chr12:27466568(+) A-G intron -    22484847 chr12:27467244(+) A-G intron -    22484847 chr12:27467353(+) G-A intron -    22484847 chr12:27471752(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STK38L	chr12:27450782-27450783(+) m6A CDS//exon       24981863 chr12:27450808-27450809(+) m6A exon//intron       24981863 chr12:27450853-27450854(+) m6A exon//intron       24981863 chr12:27461307-27461308(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461331-27461332(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461336-27461337(+) m6A 3'UTR//CDS//intron       24981863 chr12:27470286-27470287(+) m6A 3'UTR//CDS       24981863 chr12:27470322-27470323(+) m6A 3'UTR//CDS       24981863 chr12:27470939-27470940(+) m6A 3'UTR//CDS//exon       24981863 chr12:27472280-27472281(+) m6A 3'UTR//CDS//exon       24981863 chr12:27475276-27475277(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475281-27475282(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475296-27475297(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475419-27475420(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr12:27475538-27475539(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr12:27475637-27475638(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475712-27475713(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475742-27475743(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27476030-27476031(+) m6A 3'UTR       27773535 chr12:27476550-27476551(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	STK38L	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART15
Interactor2: STK38L

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

[1]PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

[2]PMID	22291592	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).