Basic Information:

  VIRBase ID:  

VHID00357966

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART15:  MIMAT0003713          FXR1:  NM_001013438     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART15	FXR1
miRBase Accession/Entrez ID	MIMAT0003713	8087
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	FXR1P//MYOPMIL//MYORIBF

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FXR1	chr3:180634237(+) A-I      intronic chr3:180634370(+) A-I      intronic chr3:180634379(+) A-I      intronic chr3:180634405(+) A-I      intronic chr3:180634485(+) A-I      intronic chr3:180634687(+) A-I      intronic chr3:180634768(+) A-I      intronic chr3:180634772(+) A-I      intronic chr3:180637525(+) A-I      intronic chr3:180638355(+) A-I      intronic chr3:180638361(+) A-I      intronic chr3:180638364(+) A-I      intronic chr3:180638449(+) A-I      intronic chr3:180638508(+) A-I      intronic chr3:180638903(+) A-I      intronic chr3:180639003(+) A-I      intronic chr3:180639005(+) A-I      intronic chr3:180639012(+) A-I      intronic chr3:180641913(+) A-I      intronic chr3:180642931(+) A-I      intronic chr3:180642934(+) A-I      intronic chr3:180642948(+) A-I      intronic chr3:180643018(+) A-I      intronic chr3:180643038(+) A-I      intronic chr3:180643051(+) A-I      intronic chr3:180643093(+) A-I      intronic chr3:180643127(+) A-I      intronic chr3:180646810(+) A-I      intronic chr3:180646827(+) A-I      intronic chr3:180647867(+) A-I      intronic chr3:180647875(+) A-I      intronic chr3:180647904(+) A-I      intronic chr3:180647975(+) A-I      intronic chr3:180648624(+) A-I      intronic chr3:180648627(+) A-I      intronic chr3:180648647(+) A-I      intronic chr3:180648662(+) A-I      intronic chr3:180648663(+) A-I      intronic chr3:180648664(+) A-I      intronic chr3:180648726(+) A-I      intronic chr3:180648729(+) A-I      intronic chr3:180689990(+) A-I      intronic chr3:180670905(+) A-I      intronic chr3:180668794(+) A-I      intronic chr3:180668793(+) A-I      intronic chr3:180662523(+) A-I      intronic chr3:180648772(+) A-I      intronic chr3:180648774(+) A-I      intronic chr3:180648796(+) A-I      intronic chr3:180648818(+) A-I      intronic chr3:180653943(+) A-I      intronic chr3:180659911(+) A-I      intronic chr3:180659966(+) A-I      intronic chr3:180659979(+) A-I      intronic chr3:180660032(+) A-I      intronic chr3:180660051(+) A-I      intronic chr3:180660055(+) A-I      intronic chr3:180660136(+) A-I      intronic chr3:180662234(+) A-I      intronic chr3:180662349(+) A-I      intronic chr3:180662367(+) A-I      intronic chr3:180662476(+) A-I      intronic chr3:180662480(+) A-I      intronic chr3:180662576(+) A-I      intronic chr3:180662585(+) A-I      intronic chr3:180663425(+) A-I      intronic chr3:180664982(+) A-I      intronic chr3:180667274(+) A-I      intronic chr3:180668792(+) A-I      intronic chr3:180668874(+) A-I      intronic chr3:180669712(+) A-I      intronic chr3:180669975(+) A-I      intronic chr3:180670202(+) A-I      intronic chr3:180670230(+) A-I      intronic chr3:180670251(+) A-I      intronic chr3:180670360(+) A-I      intronic chr3:180679085(+) A-I      intronic chr3:180679154(+) A-I      intronic chr3:180690022(+) A-I      intronic chr3:180690097(+) A-I      intronic chr3:180690110(+) A-I      intronic chr3:180690133(+) A-I      intronic chr3:180690156(+) A-I      intronic chr3:180690190(+) A-I      intronic chr3:180691977(+) A-I      intronic chr3:180691990(+) A-I      intronic chr3:180692026(+) A-I      intronic chr3:180692050(+) A-I      intronic chr3:180692082(+) A-I      intronic chr3:180692086(+) A-I      intronic chr3:180692098(+) A-I      intronic chr3:180692140(+) A-I      intronic chr3:180692192(+) A-I      intronic chr3:180692193(+) A-I      intronic chr3:180692205(+) A-I      intronic chr3:180692218(+) A-I      intronic chr3:180659928(+) A-I      intronic chr3:180687536(+) A-I      intronic chr3:180659917(+) A-I      intronic chr3:180648667(+) A-I      intronic chr3:180634678(+) A-I      intronic chr3:180667382(+) A-I      intronic chr3:180670867(+) A-I      intronic chr3:180648658(+) A-I      intronic chr3:180646889(+) A-I      intronic chr3:180647940(+) A-I      intronic chr3:180658444(+) A-I      intronic chr3:180637190(+) A-I      intronic chr3:180638434(+) A-I      intronic chr3:180647972(+) A-I      intronic chr3:180635579(+) A-I      intronic chr3:180635592(+) A-I      intronic chr3:180664971(+) A-I      intronic chr3:180660107(+) A-I      intronic chr3:180648675(+) A-I      intronic chr3:180638567(+) A-I      intronic chr3:180635584(+) A-I      intronic chr3:180649693(+) A-I      intronic chr3:180678943(+) A-I      intronic chr3:180635548(+) A-I      intronic chr3:180641896(+) A-I      intronic chr3:180647798(+) A-I      intronic chr3:180639126(+) A-I      intronic chr3:180690226(+) A-I      intronic chr3:180648616(+) A-I      intronic chr3:180634885(+) A-I      intronic chr3:180635559(+) A-I      intronic chr3:180670206(+) A-I      intronic chr3:180670255(+) A-I      intronic chr3:180635690(+) A-I      intronic chr3:180647931(+) A-I      intronic chr3:180646814(+) A-I      intronic chr3:180669740(+) A-I      intronic chr3:180635676(+) A-I      intronic chr3:180649187(+) A-I      intronic chr3:180634362(+) A-I      intronic chr3:180648673(+) A-I      intronic chr3:180635558(+) A-I      intronic chr3:180635549(+) A-I      intronic chr3:180670721(+) A-I      intronic chr3:180670853(+) A-I      intronic chr3:180635656(+) A-I      intronic chr3:180678371(+) A-I      intronic chr3:180647874(+) A-I      intronic chr3:180641930(+) A-I      intronic chr3:180649701(+) A-I      intronic chr3:180639035(+) A-I      intronic chr3:180635667(+) A-I      intronic chr3:180643050(+) A-I      intronic chr3:180635520(+) A-I      intronic chr3:180648645(+) A-I      intronic chr3:180638439(+) A-I      intronic chr3:180635551(+) A-I      intronic chr3:180692046(+) A-I      intronic chr3:180635588(+) A-I      intronic chr3:180648723(+) A-I      intronic chr3:180641912(+) A-I      intronic chr3:180670852(+) A-I      intronic chr3:180668819(+) A-I      intronic chr3:180640540(+) A-I      intronic chr3:180646733(+) A-I      intronic chr3:180661761(+) A-I      intronic chr3:180648797(+) A-I      intronic chr3:180664976(+) A-I      intronic chr3:180635632(+) A-I      intronic chr3:180634282(+) A-I      intronic chr3:180638399(+) A-I      intronic chr3:180660045(+) A-I      intronic chr3:180635525(+) A-I      intronic chr3:180635624(+) A-I      intronic chr3:180670294(+) A-I      intronic chr3:180648799(+) A-I      intronic chr3:180662676(+) A-I      intronic chr3:180648719(+) A-I      intronic chr3:180635481(+) A-I      intronic chr3:180646729(+) A-I      intronic chr3:180668931(+) A-I      intronic chr3:180648737(+) A-I      intronic chr3:180648608(+) A-I      intronic chr3:180639121(+) A-I      intronic chr3:180647996(+) A-I      intronic chr3:180647895(+) A-I      intronic chr3:180647957(+) A-I      intronic chr3:180690159(+) A-I      intronic chr3:180659032(+) A-I      intronic chr3:180670020(+) A-I      intronic chr3:180639036(+) A-I      intronic chr3:180638997(+) A-I      intronic chr3:180664844(+) A-I      intronic chr3:180659889(+) A-I      intronic chr3:180634313(+) A-I      intronic chr3:180662389(+) A-I      intronic chr3:180668914(+) A-I      intronic chr3:180648670(+) A-I      intronic chr3:180648671(+) A-I      intronic chr3:180648644(+) A-I      intronic chr3:180635482(+) A-I      intronic chr3:180692047(+) A-I      intronic chr3:180646849(+) A-I      intronic chr3:180635655(+) A-I      intronic chr3:180662157(+) A-I      intronic chr3:180641908(+) A-I      intronic chr3:180662248(+) A-I      intronic chr3:180638972(+) A-I      intronic chr3:180648706(+) A-I      intronic chr3:180661190(+) A-I      intronic chr3:180634361(+) A-I      intronic chr3:180646839(+) A-I      intronic chr3:180670754(+) A-I      intronic chr3:180641847(+) A-I      intronic chr3:180635553(+) A-I      intronic chr3:180678383(+) A-I      intronic chr3:180668743(+) A-I      intronic chr3:180667275(+) A-I      intronic chr3:180692051(+) A-I      intronic chr3:180639017(+) A-I      intronic chr3:180648565(+) A-I      intronic chr3:180664966(+) A-I      intronic chr3:180648613(+) A-I      intronic chr3:180638533(+) A-I      intronic chr3:180668732(+) A-I      intronic chr3:180662611(+) A-I      intronic chr3:180638465(+) A-I      intronic chr3:180678347(+) A-I      intronic chr3:180643002(+) A-I      intronic chr3:180635614(+) A-I      intronic chr3:180638902(+) A-I      intronic chr3:180660072(+) A-I      intronic chr3:180670248(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FXR1	chr3:180635481(+) A-I intron -    22028664 chr3:180635482(+) A-I intron -    22028664 chr3:180635520(+) A-I intron -    22028664 chr3:180635525(+) A-I intron -    22028664 chr3:180635548(+) A-I intron -    22028664 chr3:180635549(+) A-I intron -    22028664 chr3:180635551(+) A-I intron -    22028664 chr3:180635553(+) A-I intron -    22028664 chr3:180635558(+) A-I intron -    22028664 chr3:180635559(+) A-I intron -    22028664 chr3:180635579(+) A-I intron -    22028664 chr3:180635584(+) A-I intron -    22028664 chr3:180635592(+) A-I intron -    22028664 chr3:180635604(+) A-I intron -    22028664 chr3:180635624(+) A-I intron -    22028664 chr3:180635632(+) A-I intron -    22028664 chr3:180635655(+) A-I intron -    22028664 chr3:180635656(+) A-I intron -    22028664 chr3:180635667(+) A-I intron -    22028664 chr3:180635676(+) A-I intron -    22028664 chr3:180635690(+) A-I intron -    22028664 chr3:180690123(+) A-I intron -    21960545 chr3:180634282(+) A-G intron -    22484847 chr3:180634400(+) A-G intron -    22484847 chr3:180635520(+) A-G intron -    22484847 chr3:180635525(+) A-G intron -    22484847 chr3:180635588(+) A-G intron -    22484847 chr3:180635614(+) A-G intron -    22484847 chr3:180635624(+) A-G intron -    22484847 chr3:180635655(+) A-G intron -    22484847 chr3:180637526(+) A-G intron -    22484847 chr3:180638363(+) A-G intron -    22484847 chr3:180638393(+) A-G intron -    22484847 chr3:180638399(+) A-G intron -    22484847 chr3:180638465(+) A-G intron -    22484847 chr3:180638473(+) A-G intron -    22484847 chr3:180638482(+) A-G intron -    22484847 chr3:180638533(+) A-G intron -    22484847 chr3:180638902(+) A-G intron -    22484847 chr3:180639009(+) A-G intron -    22484847 chr3:180639017(+) A-G intron -    22484847 chr3:180640535(+) A-G intron -    22484847 chr3:180641908(+) A-G intron -    22484847 chr3:180647930(+) A-G intron -    22484847 chr3:180647931(+) A-G intron -    22484847 chr3:180647940(+) A-G intron -    22484847 chr3:180647972(+) A-G intron -    22484847 chr3:180648644(+) A-G intron -    22484847 chr3:180648658(+) A-G intron -    22484847 chr3:180649692(+) A-G intron -    22484847 chr3:180649693(+) A-G intron -    22484847 chr3:180649701(+) A-G intron -    22484847 chr3:180651766(+) T-C intron -    22484847 chr3:180658368(+) G-T intron -    22484847 chr3:180659912(+) A-G intron -    22484847 chr3:180662248(+) A-G intron -    22484847 chr3:180662608(+) A-G intron -    22484847 chr3:180662611(+) A-G intron -    22484847 chr3:180664966(+) A-G intron -    22484847 chr3:180664976(+) A-G intron -    22484847 chr3:180667275(+) A-G intron -    22484847 chr3:180668732(+) A-G intron -    22484847 chr3:180668743(+) A-G intron -    22484847 chr3:180668914(+) A-G intron -    22484847 chr3:180668931(+) A-G intron -    22484847 chr3:180668936(+) A-G intron -    22484847 chr3:180670206(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FXR1	chr3:180632537-180632538(+) m6A 5'UTR//intron       - chr3:180632602-180632603(+) m6A 5'UTR//intron       24981863 chr3:180632644-180632645(+) m6A 5'UTR//intron       24209618//24981863 chr3:180632698-180632699(+) m6A 5'UTR//intron       - chr3:180632713-180632714(+) m6A 5'UTR//intron       - chr3:180632766-180632767(+) m6A 5'UTR//intron       - chr3:180651146-180651147(+) m6A 5'UTR//CDS//exon//intron       24981863 chr3:180669160-180669161(+) m6A CDS//exon       24981863 chr3:180669235-180669236(+) m6A CDS//exon       24981863 chr3:180671664-180671665(+) m6A exon//intron       24981863 chr3:180675651-180675652(+) m6A CDS//exon       24981863//22575960 chr3:180675687-180675688(+) m6A CDS//exon       27773535//22575960 chr3:180680721-180680722(+) Cm CDS//exon       - chr3:180680855-180680856(+) m6A CDS//exon       22575960 chr3:180685931-180685932(+) m6A CDS//exon       27773535//22575960 chr3:180686010-180686011(+) m6A CDS//exon       22575960 chr3:180688073-180688074(+) m6A CDS//exon       27773535 chr3:180688217-180688218(+) m6A exon//intron       27773535 chr3:180693178-180693179(+) m6A CDS//exon//intron       27773535 chr3:180694042-180694043(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:180694080-180694081(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr3:180694244-180694245(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr3:180694445-180694446(+) Y 3'UTR       25219674 chr3:180694545-180694546(+) m6A 3'UTR       27773535 chr3:180694599-180694600(+) m6A 3'UTR       27773535 chr3:180694621-180694622(+) m6A 3'UTR       27773535 chr3:180694637-180694638(+) m6A 3'UTR       27773535 chr3:180694722-180694723(+) m6A 3'UTR       27773535 chr3:180694739-180694740(+) m6A 3'UTR       27773535 chr3:180694770-180694771(+) m6A 3'UTR       27773535 chr3:180694781-180694782(+) m6A 3'UTR       27773535 chr3:180694823-180694824(+) m6A 3'UTR       27773535 chr3:180697013-180697014(+) m6A 3'UTR       24981863//22608085 chr3:180697038-180697039(+) m6A 3'UTR       24981863//22608085 chr3:180697072-180697073(+) m6A 3'UTR       24981863//22608085 chr3:180697080-180697081(+) m6A 3'UTR       24981863//22608085 chr3:180697089-180697090(+) m6A 3'UTR       24981863//22608085 chr3:180697106-180697107(+) m6A 3'UTR       24981863//22608085 chr3:180697179-180697180(+) m6A 3'UTR       24981863//22608085 chr3:180697191-180697192(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FXR1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome HeLa cells     24205503 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART15
Interactor2: FXR1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

[1]PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

[2]PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).