Basic Information:

  VIRBase ID:  

VHID00357898

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART15:  MIMAT0003713          YWHAG:  NM_012479     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART15	YWHAG
miRBase Accession/Entrez ID	MIMAT0003713	7532
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	14-3-3GAMMA//DEE56//EIEE56//PPP1R170

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	YWHAG	chr7:75982105(-) A-I      intronic chr7:75982090(-) A-I      intronic chr7:75983281(-) A-I      intronic chr7:75983664(-) A-I      intronic chr7:75980109(-) A-I      intronic chr7:75980078(-) A-I      intronic chr7:75980061(-) A-I      intronic chr7:75978521(-) A-I      intronic chr7:75978417(-) A-I      intronic chr7:75978416(-) A-I      intronic chr7:75978037(-) A-I      intronic chr7:75977853(-) A-I      intronic chr7:75977713(-) A-I      intronic chr7:75977654(-) A-I      intronic chr7:75974571(-) A-I      intronic chr7:75976821(-) A-I      intronic chr7:75976794(-) A-I      intronic chr7:75976757(-) A-I      intronic chr7:75976697(-) A-I      intronic chr7:75976692(-) A-I      intronic chr7:75976688(-) A-I      intronic chr7:75975082(-) A-I      intronic chr7:75975030(-) A-I      intronic chr7:75975017(-) A-I      intronic chr7:75974588(-) A-I      intronic chr7:75973629(-) A-I      intronic chr7:75973588(-) A-I      intronic chr7:75969282(-) A-I      intronic chr7:75967125(-) A-I      intronic chr7:75967120(-) A-I      intronic chr7:75967025(-) A-I      intronic chr7:75966980(-) A-I      intronic chr7:75965198(-) A-I      intronic chr7:75963970(-) A-I      intronic chr7:75962709(-) A-I      intronic chr7:75962648(-) A-I      intronic chr7:75976748(-) A-I      intronic chr7:75976767(-) A-I      intronic chr7:75976795(-) A-I      intronic chr7:75976816(-) A-I      intronic chr7:75976840(-) A-I      intronic chr7:75982658(-) A-I      intronic chr7:75982662(-) A-I      intronic chr7:75983260(-) A-I      intronic chr7:75983716(-) A-I      intronic chr7:75983833(-) A-I      intronic chr7:75983728(-) A-I      intronic chr7:75983719(-) A-I      intronic chr7:75976851(-) A-I      intronic chr7:75983706(-) A-I      intronic chr7:75983662(-) A-I      intronic chr7:75983636(-) A-I      intronic chr7:75983583(-) A-I      intronic chr7:75983571(-) A-I      intronic chr7:75983278(-) A-I      intronic chr7:75983220(-) A-I      intronic chr7:75982713(-) A-I      intronic chr7:75982668(-) A-I      intronic chr7:75982667(-) A-I      intronic chr7:75982635(-) A-I      intronic chr7:75982606(-) A-I      intronic chr7:75982131(-) A-I      intronic chr7:75956836(-) A-I      3'UTR chr7:75976772(-) A-I      intronic chr7:75967046(-) A-I      intronic chr7:75970227(-) A-I      intronic chr7:75977673(-) A-I      intronic chr7:75963992(-) A-I      intronic chr7:75977916(-) A-I      intronic chr7:75972342(-) A-I      intronic chr7:75966990(-) A-I      intronic chr7:75976834(-) A-I      intronic chr7:75969320(-) A-I      intronic chr7:75970329(-) A-I      intronic chr7:75975016(-) A-I      intronic chr7:75973603(-) A-I      intronic chr7:75965205(-) A-I      intronic chr7:75979106(-) A-I      intronic chr7:75977859(-) A-I      intronic chr7:75964157(-) A-I      intronic chr7:75979123(-) A-I      intronic chr7:75967090(-) A-I      intronic chr7:75974687(-) A-I      intronic chr7:75966967(-) A-I      intronic chr7:75983593(-) A-I      intronic chr7:75975089(-) A-I      intronic chr7:75962453(-) A-I      intronic chr7:75978492(-) A-I      intronic chr7:75970530(-) A-I      intronic chr7:75978537(-) A-I      intronic chr7:75983268(-) A-I      intronic chr7:75982632(-) A-I      intronic chr7:75976820(-) A-I      intronic chr7:75975086(-) A-I      intronic chr7:75966954(-) A-I      intronic chr7:75976663(-) A-I      intronic chr7:75982187(-) A-I      intronic chr7:75974775(-) A-I      intronic chr7:75967034(-) A-I      intronic chr7:75966944(-) A-I      intronic chr7:75976657(-) A-I      intronic chr7:75965050(-) A-I      intronic chr7:75982698(-) A-I      intronic chr7:75965065(-) A-I      intronic chr7:75983309(-) A-I      intronic chr7:75965229(-) A-I      intronic chr7:75978470(-) A-I      intronic chr7:75976709(-) A-I      intronic chr7:75973631(-) A-I      intronic chr7:75977652(-) A-I      intronic chr7:75975041(-) A-I      intronic chr7:75970590(-) A-I      intronic chr7:75962425(-) A-I      intronic chr7:75983362(-) A-I      intronic chr7:75962692(-) A-I      intronic chr7:75980142(-) A-I      intronic chr7:75970715(-) A-I      intronic chr7:75973592(-) A-I      intronic chr7:75965858(-) A-I      intronic chr7:75975130(-) A-I      intronic chr7:75978039(-) A-I      intronic chr7:75977776(-) A-I      intronic chr7:75970254(-) A-I      intronic chr7:75962640(-) A-I      intronic chr7:75965063(-) A-I      intronic chr7:75963871(-) A-I      intronic chr7:75978593(-) A-I      intronic chr7:75975152(-) A-I      intronic chr7:75975140(-) A-I      intronic chr7:75970527(-) A-I      intronic chr7:75977926(-) A-I      intronic chr7:75965376(-) A-I      intronic chr7:75979163(-) A-I      intronic chr7:75976791(-) A-I      intronic chr7:75967055(-) A-I      intronic chr7:75978403(-) A-I      intronic chr7:75983766(-) A-I      intronic chr7:75970661(-) A-I      intronic chr7:75975211(-) A-I      intronic chr7:75982627(-) A-I      intronic chr7:75967021(-) A-I      intronic chr7:75977993(-) A-I      intronic chr7:75973470(-) A-I      intronic chr7:75962620(-) A-I      intronic chr7:75979259(-) A-I      intronic chr7:75982809(-) A-I      intronic chr7:75976827(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	YWHAG	chr7:75962640(-) A-G intron -    22484847 chr7:75963871(-) A-G intron -    22484847 chr7:75963932(-) A-G intron -    22484847 chr7:75963950(-) A-G intron -    22484847 chr7:75965185(-) A-G intron -    22484847 chr7:75965376(-) A-G intron -    22484847 chr7:75966954(-) A-G intron -    22484847 chr7:75966990(-) A-G intron -    22484847 chr7:75969320(-) A-G intron -    22484847 chr7:75969376(-) A-G intron -    22484847 chr7:75970638(-) A-G intron -    22484847 chr7:75973592(-) A-G intron -    22484847 chr7:75974641(-) A-G intron -    22484847 chr7:75974680(-) A-G intron -    22484847 chr7:75974684(-) A-G intron -    22484847 chr7:75974687(-) A-G intron -    22484847 chr7:75975015(-) A-G intron -    22484847 chr7:75975016(-) A-G intron -    22484847 chr7:75975086(-) A-G intron -    22484847 chr7:75975211(-) A-G intron -    22484847 chr7:75975244(-) A-G intron -    22484847 chr7:75976820(-) A-G intron -    22484847 chr7:75976827(-) A-G intron -    22484847 chr7:75976834(-) A-G intron -    22484847 chr7:75977859(-) A-G intron -    22484847 chr7:75977865(-) A-G intron -    22484847 chr7:75977916(-) A-G intron -    22484847 chr7:75977917(-) A-G intron -    22484847 chr7:75977926(-) A-G intron -    22484847 chr7:75977993(-) A-G intron -    22484847 chr7:75978470(-) A-G intron -    22484847 chr7:75978492(-) A-G intron -    22484847 chr7:75978537(-) A-G intron -    22484847 chr7:75978547(-) A-G intron -    22484847 chr7:75978593(-) A-G intron -    22484847 chr7:75980142(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	YWHAG	chr7:75956335-75956336(-) m6A 3'UTR       26404942 chr7:75956407-75956408(-) m6A 3'UTR       26404942 chr7:75956784-75956785(-) m6A 3'UTR       26404942 chr7:75956886-75956887(-) m6A 3'UTR       26404942 chr7:75957081-75957082(-) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr7:75957190-75957191(-) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr7:75957206-75957207(-) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr7:75957251-75957252(-) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr7:75957298-75957299(-) m6A 3'UTR       24981863//26404942//22575960//22608085 chr7:75957386-75957387(-) m6A 3'UTR       26404942 chr7:75957522-75957523(-) m6A 3'UTR       26404942 chr7:75957624-75957625(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr7:75957641-75957642(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr7:75957648-75957649(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr7:75957666-75957667(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr7:75957703-75957704(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr7:75957785-75957786(-) m6A 3'UTR       24284625//26404942 chr7:75957986-75957987(-) m6A 3'UTR       24284625 chr7:75958395-75958396(-) m6A 3'UTR       26404942 chr7:75958402-75958403(-) m6A 3'UTR       26404942 chr7:75958410-75958411(-) m6A 3'UTR       26404942 chr7:75958426-75958427(-) m6A 3'UTR       26404942 chr7:75958433-75958434(-) m6A 3'UTR       26404942 chr7:75958575-75958576(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:75958660-75958661(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr7:75958776-75958777(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:75958880-75958881(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr7:75958984-75958985(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr7:75958996-75958997(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr7:75959042-75959043(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr7:75959162-75959163(-) Gm CDS       - chr7:75959251-75959252(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr7:75959294-75959295(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:75959405-75959406(-) m1A CDS       26863196 chr7:75959429-75959430(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:75959509-75959510(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960 chr7:75988033-75988034(-) Gm intron       - chr7:75988117-75988118(-) m6A CDS       24284625//24981863//26404942//27371828//27773536//22575960 chr7:75988140-75988141(-) m6A 5'UTR       24284625//24981863//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	YWHAG	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART15
Interactor2: YWHAG

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.