Basic Information:

  VIRBase ID:  

VHID00352351

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART14-3p:  MIMAT0003426          KRAS:  NM_001369787     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART14-3p	KRAS
miRBase Accession/Entrez ID	MIMAT0003426	3845
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	'C-K-RAS//C-K-RAS//c-Ki-ras//c-Ki-ras2//CFC2//K-Ras//K-Ras 2//K-RAS2A//K-RAS2B//K-RAS4A//K-RAS4B//KI-RAS//KRAS1//KRAS2//NS//NS3//OES//RALD//RASK2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KRAS	chr12:25364397(-) A-I      intronic chr12:25384258(-) A-I      intronic chr12:25384200(-) A-I      intronic chr12:25372046(-) A-I      intronic chr12:25384290(-) A-I      intronic chr12:25374360(-) A-I      intronic chr12:25384190(-) A-I      intronic chr12:25374361(-) A-I      intronic chr12:25384240(-) A-I      intronic chr12:25374327(-) A-I      intronic chr12:25372011(-) A-I      intronic chr12:25374275(-) A-I      intronic chr12:25384234(-) A-I      intronic chr12:25372052(-) A-I      intronic chr12:25372051(-) A-I      intronic chr12:25372048(-) A-I      intronic chr12:25372037(-) A-I      intronic chr12:25372042(-) A-I      intronic chr12:25372043(-) A-I      intronic chr12:25383424(-) A-I      intronic chr12:25383462(-) A-I      intronic chr12:25374331(-) A-I      intronic chr12:25383413(-) A-I      intronic chr12:25383360(-) A-I      intronic chr12:25382978(-) A-I      intronic chr12:25382867(-) A-I      intronic chr12:25382827(-) A-I      intronic chr12:25381858(-) A-I      intronic chr12:25374975(-) A-I      intronic chr12:25384132(-) A-I      intronic chr12:25401045(-) A-I      intronic chr12:25401203(-) A-I      intronic chr12:25365438(-) A-I      intronic chr12:25374971(-) A-I      intronic chr12:25383515(-) A-I      intronic chr12:25370746(-) A-I      intronic chr12:25381830(-) A-I      intronic chr12:25372001(-) A-I      intronic chr12:25374258(-) A-I      intronic chr12:25383499(-) A-I      intronic chr12:25374264(-) A-I      intronic chr12:25381750(-) A-I      intronic chr12:25382964(-) A-I      intronic chr12:25382915(-) A-I      intronic chr12:25374961(-) A-I      intronic chr12:25370728(-) A-I      intronic chr12:25383418(-) A-I      intronic chr12:25382779(-) A-I      intronic chr12:25383510(-) A-I      intronic chr12:25402183(-) A-I      intronic chr12:25369459(-) A-I      intronic chr12:25399380(-) A-I      intronic chr12:25374252(-) A-I      intronic chr12:25370742(-) A-I      intronic chr12:25365781(-) A-I      intronic chr12:25381735(-) A-I      intronic chr12:25371969(-) A-I      intronic chr12:25370776(-) A-I      intronic chr12:25374400(-) A-I      intronic chr12:25374342(-) A-I      intronic chr12:25383306(-) A-I      intronic chr12:25374234(-) A-I      intronic chr12:25383493(-) A-I      intronic chr12:25383365(-) A-I      intronic chr12:25369311(-) A-I      intronic chr12:25374263(-) A-I      intronic chr12:25384160(-) A-I      intronic chr12:25365830(-) A-I      intronic chr12:25369468(-) A-I      intronic chr12:25365829(-) A-I      intronic chr12:25374304(-) A-I      intronic chr12:25364479(-) A-I      intronic chr12:25374395(-) A-I      intronic chr12:25365845(-) A-I      intronic chr12:25365441(-) A-I      intronic chr12:25365803(-) A-I      intronic chr12:25365735(-) A-I      intronic chr12:25382886(-) A-I      intronic chr12:25384213(-) A-I      intronic chr12:25382928(-) A-I      intronic chr12:25384174(-) A-I      intronic chr12:25374256(-) A-I      intronic chr12:25374423(-) A-I      intronic chr12:25383480(-) A-I      intronic chr12:25384289(-) A-I      intronic chr12:25365741(-) A-I      intronic chr12:25381825(-) A-I      intronic chr12:25373896(-) A-I      intronic chr12:25374290(-) A-I      intronic chr12:25365415(-) A-I      intronic chr12:25365746(-) A-I      intronic chr12:25370828(-) A-I      intronic chr12:25382935(-) A-I      intronic chr12:25383479(-) A-I      intronic chr12:25374935(-) A-I      intronic chr12:25374371(-) A-I      intronic chr12:25369347(-) A-I      intronic chr12:25384184(-) A-I      intronic chr12:25374340(-) A-I      intronic chr12:25374895(-) A-I      intronic chr12:25401160(-) A-I      intronic chr12:25384248(-) A-I      intronic chr12:25381776(-) A-I      intronic chr12:25374372(-) A-I      intronic chr12:25364422(-) A-I      intronic chr12:25401321(-) A-I      intronic chr12:25383557(-) A-I      intronic chr12:25383559(-) A-I      intronic chr12:25374295(-) A-I      intronic chr12:25372145(-) A-I      intronic chr12:25401161(-) A-I      intronic chr12:25382940(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KRAS	chr12:25365741(-) A-I intron -    21960545   //22327324 chr12:25365781(-) A-I intron -    21960545   //22327324 chr12:25365415(-) A-I intron -    21960545 chr12:25365416(-) A-I intron -    21960545 chr12:25365829(-) A-I intron -    21960545 chr12:25365830(-) A-I intron -    21960545 chr12:25365833(-) A-I intron -    21960545 chr12:25369307(-) A-I intron -    21960545 chr12:25369341(-) A-I intron -    21960545 chr12:25369347(-) A-I intron -    21960545 chr12:25370623(-) A-I intron -    21960545 chr12:25370728(-) A-I intron -    21960545 chr12:25370746(-) A-I intron -    21960545 chr12:25370776(-) A-I intron -    21960545 chr12:25370828(-) A-I intron -    21960545 chr12:25382901(-) A-I intron -    21960545 chr12:25383306(-) A-I intron -    21960545 chr12:25383424(-) A-I intron -    21960545 chr12:25383557(-) A-I intron -    21960545 chr12:25360448(-) G-T exon 3'UTR    22484847 chr12:25360449(-) G-T exon 3'UTR    22484847 chr12:25365741(-) A-G intron -    22484847 chr12:25365781(-) A-G intron -    22484847 chr12:25365958(-) T-C intron -    22484847 chr12:25374244(-) T-C intron -    22484847 chr12:25382928(-) A-G intron -    22484847 chr12:25382935(-) A-G intron -    22484847 chr12:25383480(-) A-G intron -    22484847 chr12:25369303(-) T-C intron -    22484847 chr12:25370828(-) A-G intron -    22484847 chr12:25372145(-) A-G intron -    22484847 chr12:25374395(-) A-G intron -    22484847 chr12:25374400(-) A-G intron -    22484847 chr12:25374423(-) A-G intron -    22484847 chr12:25374895(-) A-G intron -    22484847 chr12:25382780(-) T-C intron -    22484847 chr12:25383365(-) A-G intron -    22484847 chr12:25383479(-) A-G intron -    22484847 chr12:25383493(-) A-G intron -    22484847 chr12:25383510(-) A-G intron -    22484847 chr12:25384160(-) A-G intron -    22484847 chr12:25384184(-) A-G intron -    22484847 chr12:25401160(-) A-G intron -    22484847 chr12:25401161(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KRAS	chr12:25362748-25362749(-) m6A 3'UTR//CDS       24981863//27773535 chr12:25362800-25362801(-) m6A 3'UTR//CDS       24981863//27773535//27371828 chr12:25368415-25368416(-) m6A CDS//intron       27773535//27371828 chr12:25378550-25378551(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378555-25378556(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378567-25378568(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378602-25378603(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378613-25378614(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378620-25378621(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378627-25378628(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378683-25378684(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25378703-25378704(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr12:25380237-25380238(-) m6A CDS//intron       24981863//26404942//27773535 chr12:25380251-25380252(-) m6A CDS//intron       24981863//26404942//27773535 chr12:25380309-25380310(-) m6A CDS//intron       24981863//26404942//27773535 chr12:25387487-25387488(-) m6A 3'UTR//intron       27773535 chr12:25387524-25387525(-) m6A 3'UTR//intron       27773535 chr12:25398303-25398304(-) m6A CDS       24209618//27371828 chr12:25403761-25403762(-) m6A 5'UTR       24209618//24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART14-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	KRAS	Chromatin K562 cells     - Exosome Serum     - Mitochondrion HDF cells     16178658 Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART14-3p
Interactor2: KRAS

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.