Basic Information:

  VIRBase ID:  

VHID00351686

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART14-5p:  MIMAT0003425          PTENP1:  NR_023917     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART14-5p	PTENP1
miRBase Accession/Entrez ID	MIMAT0003425	11191
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	pseudo
Alias	-	psiPTEN//PTEN-rs//PTEN2//PTENpg1//PTH2

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	PTENP1	chr9: 33676402

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PTENP1	chr9:33676402(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PTENP1	chr9:33675386-33675387(-) m6A exon       24981863 chr9:33675400-33675401(-) m6A exon       24981863 chr9:33675411-33675412(-) m6A exon       24981863 chr9:33675479-33675480(-) m6A exon       24981863 chr9:33675530-33675531(-) m6A exon       24981863 chr9:33675793-33675794(-) m6A exon       22608085 chr9:33675803-33675804(-) m6A exon       22608085 chr9:33675846-33675847(-) m6A exon       22608085 chr9:33675864-33675865(-) m6A exon       22608085 chr9:33675869-33675870(-) m6A exon       22608085 chr9:33676164-33676165(-) m6A exon       22608085 chr9:33676171-33676172(-) m6A exon       22608085 chr9:33676258-33676259(-) m6A exon       24981863 chr9:33676343-33676344(-) m6A exon       24981863//22608085 chr9:33676352-33676353(-) m6A exon       24981863//22608085 chr9:33676374-33676375(-) m6A exon       24981863//22608085 chr9:33676427-33676428(-) m6A exon       24981863//22608085 chr9:33676461-33676462(-) m6A exon       24981863//22608085 chr9:33676506-33676507(-) m6A exon       22608085 chr9:33676526-33676527(-) m6A exon       22608085 chr9:33676557-33676558(-) m6A exon       22608085 chr9:33676979-33676980(-) m6A exon       24981863 chr9:33676996-33676997(-) m6A exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PTENP1	Cytoplasm Cervical cancer cell lines (CasKi|HeLa)     31913710 Exosome Serum     - Nucleus Cervical cancer cell lines (CasKi|HeLa)     31913710

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART14-5p
Interactor2: PTENP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.