Basic Information:

  VIRBase ID:  

VHID00351685

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   JUN:  NP_002219     

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART14-5p	JUN
miRBase Accession/Entrez ID	MIMAT0003425	3725
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	protein
Alias	-	AP-1//AP1//c-Jun//cJUN//p39

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JUN	chr1:59246695-59246696(-) m6A 3'UTR       - chr1:59246715-59246716(-) m6A 3'UTR       - chr1:59247004-59247005(-) m6A 3'UTR       27773535 chr1:59247180-59247181(-) m6A 3'UTR       24981863//27773535 chr1:59247262-59247263(-) m6A 3'UTR       24209618//25456834//24981863//26404942//27773535//22608085 chr1:59247337-59247338(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr1:59247369-59247370(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr1:59247381-59247382(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr1:59247435-59247436(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247444-59247445(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247468-59247469(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247565-59247566(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247612-59247613(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247638-59247639(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:59247680-59247681(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:59247688-59247689(-) m6A 3'UTR       22575960 chr1:59247692-59247693(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247739-59247740(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247754-59247755(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247801-59247802(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247815-59247816(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247833-59247834(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247870-59247871(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247886-59247887(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59247957-59247958(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59248027-59248028(-) m6A CDS       24284625//24209618//27773535//27371828//27773536//22608085 chr1:59248051-59248052(-) m6A CDS       24284625//24209618//27371828//27773536//22608085 chr1:59248227-59248228(-) m6A CDS       24209618//27371828//27773536 chr1:59248368-59248369(-) m6A CDS       25456834//24981863//26404942//27371828//27773536//22608085 chr1:59248382-59248383(-) m6A CDS       25456834//24981863//26404942//27371828//27773536//22608085 chr1:59248566-59248567(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59248572-59248573(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr1:59248620-59248621(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr1:59248637-59248638(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr1:59248670-59248671(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr1:59248732-59248733(-) Am CDS       - chr1:59248749-59248750(-) m6A 5'UTR       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr1:59248772-59248773(-) m6A 5'UTR       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr1:59248791-59248792(-) m6A 5'UTR       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr1:59248861-59248862(-) m6A 5'UTR       24284625//24981863//27773535//27371828//22575960//22608085 chr1:59249040-59249041(-) m6A 5'UTR       24284625//24981863//27773535//27371828//27773536//22608085 chr1:59249050-59249051(-) m6A 5'UTR       24284625//24981863//27773535//27371828//27773536//22608085 chr1:59249136-59249137(-) m6A 5'UTR       24981863//27371828//27773536//22608085 chr1:59249164-59249165(-) m6A 5'UTR       25456834//24981863//27371828//27773536//22608085 chr1:59249225-59249226(-) m6A 5'UTR       25456834//24981863//27371828//27773536//22608085 chr1:59249263-59249264(-) m1A 5'UTR       26863410 chr1:59249296-59249297(-) m6A 5'UTR       25456834//24981863//26404942//27773535//27371828//27773536//22608085 chr1:59249368-59249369(-) m6A 5'UTR       25456834//24981863//27773535//27371828//27773536//22608085 chr1:59249375-59249376(-) m6A 5'UTR       25456834//24981863//27773535//27371828//27773536//22608085 chr1:59249393-59249394(-) m6A 5'UTR       25456834//24981863//27773535//27371828//27773536//22608085 chr1:59249608-59249609(-) m6A 5'UTR       24981863//27773535//27371828//22608085 chr1:59249644-59249645(-) m6A 5'UTR       24981863//27773535//27371828//22608085 chr1:59249652-59249653(-) m6A 5'UTR       24981863//27773535//27371828//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	JUN	Endoplasmic reticulum COS-7 cells     24019514 Exosome Blood     - Nucleolus K562 cells     - Nucleus COS-7 cells     24019514 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART14-5p
Interactor2: JUN

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR
Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	30615681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BJAB BL cells	Interactor2 expression	None
Description	Expression of the BHRF1-1, BHRF1-2, BART14, or BART18 miRNAs significantly attenuated AP1 activation (Fig 1D).