Basic Information:

  VIRBase ID:  

VHID00350642

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART14-5p:  MIMAT0003425          DCC:  NM_005215     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART14-5p	DCC
miRBase Accession/Entrez ID	MIMAT0003425	1630
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CRC18//CRCR1//HGPPS2//IGDCC1//MRMV1//NTN1R1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCC	chr18:50112359(+) A-I      intronic chr18:50112338(+) A-I      intronic chr18:50112355(+) A-I      intronic chr18:50112306(+) A-I      intronic chr18:49963091(+) A-I      intronic chr18:49936668(+) A-I      intronic chr18:49963143(+) A-I      intronic chr18:49963163(+) A-I      intronic chr18:49963216(+) A-I      intronic chr18:50004329(+) A-I      intronic chr18:50041766(+) A-I      intronic chr18:50085711(+) A-I      intronic chr18:49963098(+) A-I      intronic chr18:49963099(+) A-I      intronic chr18:50177814(+) A-I      intronic chr18:50177815(+) A-I      intronic chr18:50177827(+) A-I      intronic chr18:50839890(+) A-I      intronic chr18:51033132(+) A-I      intronic chr18:50616949(+) A-I      intronic chr18:50790714(+) A-I      intronic chr18:50041767(+) A-I      intronic chr18:50175489(+) A-I      intronic chr18:50789796(+) A-I      intronic chr18:50447978(+) A-I      intronic chr18:50111099(+) A-I      intronic chr18:50169138(+) A-I      intronic chr18:50839878(+) A-I      intronic chr18:50790736(+) A-I      intronic chr18:50171050(+) A-I      intronic chr18:50136651(+) A-I      intronic chr18:50839713(+) A-I      intronic chr18:50085599(+) A-I      intronic chr18:50291683(+) A-I      intronic chr18:50014123(+) A-I      intronic chr18:50169173(+) A-I      intronic chr18:50447948(+) A-I      intronic chr18:50066676(+) A-I      intronic chr18:50992395(+) A-I      intronic chr18:50599748(+) A-I      intronic chr18:50171005(+) A-I      intronic chr18:49995545(+) A-I      intronic chr18:50118200(+) A-I      intronic chr18:49995711(+) A-I      intronic chr18:50156199(+) A-I      intronic chr18:50447949(+) A-I      intronic chr18:50171082(+) A-I      intronic chr18:50067237(+) A-I      intronic chr18:50838933(+) A-I      intronic chr18:50171051(+) A-I      intronic chr18:50615530(+) A-I      intronic chr18:50067256(+) A-I      intronic chr18:50716436(+) A-I      intronic chr18:50839016(+) A-I      intronic chr18:50991191(+) A-I      intronic chr18:50085666(+) A-I      intronic chr18:50716401(+) A-I      intronic chr18:50616913(+) A-I      intronic chr18:50066551(+) A-I      intronic chr18:50991228(+) A-I      intronic chr18:50716442(+) A-I      intronic chr18:50169239(+) A-I      intronic chr18:50615520(+) A-I      intronic chr18:50036317(+) A-I      intronic chr18:50171004(+) A-I      intronic chr18:50616879(+) A-I      intronic chr18:50066627(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCC	chr18:50169239(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCC	chr18:49866914-49866915(+) m6A 5'UTR       25456834 chr18:49866924-49866925(+) m6A 5'UTR       25456834 chr18:49866964-49866965(+) m6A 5'UTR       25456834 chr18:51056980-51056981(+) m6A CDS       - chr18:51057060-51057061(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DCC	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART14-5p
Interactor2: DCC

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.