Detail Information

Basic Information:


  VIRBase ID:  

VHID00350617

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART14-5p:           CTSC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART14-5p CTSC
miRBase
Accession/Entrez ID		 MIMAT0003425 1075
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - CPPI//DPP-I//DPP1//DPPI//HMS//JP//JPD//PALS//PDON1//PLS

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CTSC
chr11:88055590(-) A-I      3'UTR
chr11:88055585(-) A-I      3'UTR
chr11:88067529(-) A-I      intronic
chr11:88055681(-) A-I      3'UTR
chr11:88055592(-) A-I      3'UTR
chr11:88055562(-) A-I      3'UTR
chr11:88061978(-) A-I      intronic
chr11:88057427(-) A-I      3'UTR
chr11:88055686(-) A-I      3'UTR
chr11:88055560(-) A-I      3'UTR
chr11:88055554(-) A-I      3'UTR
chr11:88055550(-) A-I      3'UTR
chr11:88055549(-) A-I      3'UTR
chr11:88057461(-) A-I      3'UTR
chr11:88057416(-) A-I      3'UTR
chr11:88055547(-) A-I      3'UTR
chr11:88055542(-) A-I      3'UTR
chr11:88057400(-) A-I      3'UTR
chr11:88057395(-) A-I      3'UTR
chr11:88057381(-) A-I      3'UTR
chr11:88057431(-) A-I      3'UTR
chr11:88055534(-) A-I      3'UTR
chr11:88057432(-) A-I      3'UTR
chr11:88057399(-) A-I      3'UTR
chr11:88057417(-) A-I      3'UTR
chr11:88057380(-) A-I      3'UTR
chr11:88057337(-) A-I      3'UTR
chr11:88057333(-) A-I      3'UTR
chr11:88057328(-) A-I      3'UTR
chr11:88055691(-) A-I      3'UTR
chr11:88055596(-) A-I      3'UTR
chr11:88055619(-) A-I      3'UTR
chr11:88055620(-) A-I      3'UTR
chr11:88055628(-) A-I      3'UTR
chr11:88055670(-) A-I      3'UTR
chr11:88055673(-) A-I      3'UTR
chr11:88055675(-) A-I      3'UTR
chr11:88063155(-) A-I      intronic
chr11:88055540(-) A-I      3'UTR
chr11:88055685(-) A-I      3'UTR
chr11:88055694(-) A-I      3'UTR
chr11:88055703(-) A-I      3'UTR
chr11:88057335(-) A-I      3'UTR
chr11:88057396(-) A-I      3'UTR
chr11:88057406(-) A-I      3'UTR
chr11:88063641(-) A-I      intronic
chr11:88063602(-) A-I      intronic
chr11:88061972(-) A-I      intronic
chr11:88063744(-) A-I      intronic
chr11:88063063(-) A-I      intronic
chr11:88062536(-) A-I      intronic
chr11:88051901(-) A-I      intronic
chr11:88063088(-) A-I      intronic
chr11:88062528(-) A-I      intronic
chr11:88062461(-) A-I      intronic
chr11:88061905(-) A-I      intronic
chr11:88063685(-) A-I      intronic
chr11:88062502(-) A-I      intronic
chr11:88063699(-) A-I      intronic
chr11:88062017(-) A-I      intronic
chr11:88061902(-) A-I      intronic
chr11:88062458(-) A-I      intronic
chr11:88062445(-) A-I      intronic
chr11:88051990(-) A-I      intronic
chr11:88063811(-) A-I      intronic
chr11:88062405(-) A-I      intronic
chr11:88061960(-) A-I      intronic
chr11:88062433(-) A-I      intronic
chr11:88063762(-) A-I      intronic
chr11:88029400(-) A-I      NonSyn:Met->Val
chr11:88061965(-) A-I      intronic
chr11:88062581(-) A-I      intronic
chr11:88062432(-) A-I      intronic
chr11:88061963(-) A-I      intronic
chr11:88068742(-) A-I      intronic
chr11:88063686(-) A-I      intronic
chr11:88063655(-) A-I      intronic
chr11:88063055(-) A-I      intronic
chr11:88062487(-) A-I      intronic
chr11:88062506(-) A-I      intronic
chr11:88062501(-) A-I      intronic
chr11:88061973(-) A-I      intronic
chr11:88062550(-) A-I      intronic
chr11:88061996(-) A-I      intronic
chr11:88063681(-) A-I      intronic
chr11:88061998(-) A-I      intronic
chr11:88063059(-) A-I      intronic
chr11:88062024(-) A-I      intronic
chr11:88063801(-) A-I      intronic
chr11:88062622(-) A-I      intronic
chr11:88061975(-) A-I      intronic
chr11:88061964(-) A-I      intronic
chr11:88062621(-) A-I      intronic
chr11:88062567(-) A-I      intronic
chr11:88051965(-) A-I      intronic
chr11:88063749(-) A-I      intronic
chr11:88063654(-) A-I      intronic
chr11:88063694(-) A-I      intronic
chr11:88062484(-) A-I      intronic
chr11:88062565(-) A-I      intronic
chr11:88061936(-) A-I      intronic
chr11:88062568(-) A-I      intronic
chr11:88063693(-) A-I      intronic
chr11:88061907(-) A-I      intronic
chr11:88062538(-) A-I      intronic
chr11:88061934(-) A-I      intronic
chr11:88055563(-) A-I      3'UTR
chr11:88055556(-) A-I      3'UTR
chr11:88055689(-) A-I      3'UTR
chr11:88055621(-) A-I      3'UTR
chr11:88057439(-) A-I      3'UTR
chr11:88057440(-) A-I      3'UTR
chr11:88055588(-) A-I      3'UTR
chr11:88055597(-) A-I      3'UTR
chr11:88055564(-) A-I      3'UTR
chr11:88055578(-) A-I      3'UTR
chr11:88057446(-) A-I      3'UTR
chr11:88055634(-) A-I      3'UTR
chr11:88055688(-) A-I      3'UTR
chr11:88055555(-) A-I      3'UTR
chr11:88055582(-) A-I      3'UTR
chr11:88055679(-) A-I      3'UTR
chr11:88055579(-) A-I      3'UTR
chr11:88055690(-) A-I      3'UTR
chr11:88055699(-) A-I      3'UTR
chr11:88055613(-) A-I      3'UTR
chr11:88055583(-) A-I      3'UTR
chr11:88055700(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CTSC
chr11:88055583(-) A-I exon 3'UTR    22327324
chr11:88055613(-) A-I exon 3'UTR    21960545
chr11:88055699(-) A-I exon 3'UTR    21960545
chr11:88055583(-) A-G exon 3'UTR    22484847
chr11:88055700(-) A-G exon 3'UTR    22484847
chr11:88061934(-) A-G intron -    22484847
chr11:88061960(-) A-G intron -    22484847
chr11:88061963(-) A-G intron -    22484847
chr11:88061964(-) A-G intron -    22484847
chr11:88061965(-) A-G intron -    22484847
chr11:88061972(-) A-G intron -    22484847
chr11:88061973(-) A-G intron -    22484847
chr11:88061975(-) A-G intron -    22484847
chr11:88061996(-) A-G intron -    22484847
chr11:88061998(-) A-G intron -    22484847
chr11:88062017(-) A-G intron -    22484847
chr11:88062432(-) A-G intron -    22484847
chr11:88062484(-) A-G intron -    22484847
chr11:88062487(-) A-G intron -    22484847
chr11:88062501(-) A-G intron -    22484847
chr11:88062502(-) A-G intron -    22484847
chr11:88062538(-) A-G intron -    22484847
chr11:88062550(-) A-G intron -    22484847
chr11:88063744(-) A-G intron -    22484847
chr11:88063749(-) A-G intron -    22484847
chr11:88063762(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CTSC
chr11:88026811-88026812(-) m6A 3'UTR       27773535
chr11:88026864-88026865(-) m6A 3'UTR       27773535
chr11:88026870-88026871(-) m6A 3'UTR       27773535
chr11:88026901-88026902(-) m6A 3'UTR       27773535
chr11:88027033-88027034(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr11:88027100-88027101(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr11:88027107-88027108(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr11:88027232-88027233(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:88027285-88027286(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:88027381-88027382(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:88027558-88027559(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr11:88029351-88029352(-) m6A CDS//exon       27773535
chr11:88054658-88054659(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr11:88054666-88054667(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054705-88054706(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054712-88054713(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054724-88054725(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054759-88054760(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054815-88054816(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054821-88054822(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054842-88054843(-) m6A 3'UTR//intron       24981863//27773535
chr11:88054876-88054877(-) m6A 3'UTR//intron       24981863
chr11:88054956-88054957(-) m6A 3'UTR//intron       24981863
chr11:88054982-88054983(-) m6A 3'UTR//intron       24981863
chr11:88055011-88055012(-) m6A 3'UTR//intron       24981863
chr11:88055095-88055096(-) m6A 3'UTR//intron       22608085
chr11:88055196-88055197(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr11:88055229-88055230(-) m6A 3'UTR//intron       22608085
chr11:88055233-88055234(-) m6A 3'UTR//intron       24981863
chr11:88055239-88055240(-) m6A 3'UTR//intron       24981863
chr11:88055290-88055291(-) m6A 3'UTR//intron       24981863
chr11:88055369-88055370(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr11:88055385-88055386(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr11:88055412-88055413(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr11:88055465-88055466(-) m6A 3'UTR//intron       24981863//27773535
chr11:88055497-88055498(-) m6A 3'UTR//intron       24981863//27773535
chr11:88055531-88055532(-) m6A 3'UTR//intron       24981863
chr11:88055546-88055547(-) m6A 3'UTR//intron       24981863
chr11:88055559-88055560(-) m6A 3'UTR//intron       24981863
chr11:88055612-88055613(-) m6A 3'UTR//intron       -
chr11:88059265-88059266(-) m6A 3'UTR//intron       24981863//28052920//27773535
chr11:88059346-88059347(-) m6A 3'UTR//intron       24284625//24981863//28052920//27773535//22608085
chr11:88059356-88059357(-) m6A 3'UTR//intron       24284625//24981863//28052920//27773535//22608085
chr11:88059375-88059376(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:88059382-88059383(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:88059397-88059398(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:88059516-88059517(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:88059540-88059541(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:88059560-88059561(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:88059573-88059574(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:88059584-88059585(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:88061287-88061288(-) m6A CDS//exon//intron       24209618
chr11:88061321-88061322(-) m6A CDS//exon//intron       -
chr11:88070907-88070908(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CTSC
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART14-5p
Interactor2: CTSC

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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