Basic Information:

  VIRBase ID:  

VHID00350452

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:  MIMAT0003424          NUDT19:  NM_001105570     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART13-3p	NUDT19
miRBase Accession/Entrez ID	MIMAT0003424	390916
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	RP2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NUDT19	chr19:33193446(+) A-I      intronic chr19:33191582(+) A-I      intronic chr19:33191617(+) A-I      intronic chr19:33193442(+) A-I      intronic chr19:33192366(+) A-I      intronic chr19:33192824(+) A-I      intronic chr19:33192873(+) A-I      intronic chr19:33204131(+) A-I      3'UTR chr19:33195902(+) A-I      intronic chr19:33192808(+) A-I      intronic chr19:33196166(+) A-I      intronic chr19:33196162(+) A-I      intronic chr19:33196128(+) A-I      intronic chr19:33195925(+) A-I      intronic chr19:33193463(+) A-I      intronic chr19:33191843(+) A-I      intronic chr19:33195886(+) A-I      intronic chr19:33195882(+) A-I      intronic chr19:33195866(+) A-I      intronic chr19:33193469(+) A-I      intronic chr19:33203004(+) A-I      3'UTR chr19:33193464(+) A-I      intronic chr19:33193459(+) A-I      intronic chr19:33195893(+) A-I      intronic chr19:33184410(+) A-I      intronic chr19:33196674(+) A-I      intronic chr19:33195780(+) A-I      intronic chr19:33195853(+) A-I      intronic chr19:33192163(+) A-I      intronic chr19:33192176(+) A-I      intronic chr19:33192192(+) A-I      intronic chr19:33192809(+) A-I      intronic chr19:33193426(+) A-I      intronic chr19:33193439(+) A-I      intronic chr19:33201679(+) A-I      intronic chr19:33201620(+) A-I      intronic chr19:33193452(+) A-I      intronic chr19:33196117(+) A-I      intronic chr19:33194388(+) A-I      intronic chr19:33194518(+) A-I      intronic chr19:33200650(+) A-I      intronic chr19:33196215(+) A-I      intronic chr19:33186189(+) A-I      intronic chr19:33186296(+) A-I      intronic chr19:33196125(+) A-I      intronic chr19:33196073(+) A-I      intronic chr19:33201391(+) A-I      intronic chr19:33201355(+) A-I      intronic chr19:33201018(+) A-I      intronic chr19:33201017(+) A-I      intronic chr19:33200660(+) A-I      intronic chr19:33200657(+) A-I      intronic chr19:33195857(+) A-I      intronic chr19:33197514(+) A-I      intronic chr19:33195854(+) A-I      intronic chr19:33196752(+) A-I      intronic chr19:33197459(+) A-I      intronic chr19:33196656(+) A-I      intronic chr19:33197342(+) A-I      intronic chr19:33186221(+) A-I      intronic chr19:33204166(+) A-I      3'UTR chr19:33204196(+) A-I      3'UTR chr19:33204086(+) A-I      3'UTR chr19:33204123(+) A-I      3'UTR chr19:33204136(+) A-I      3'UTR chr19:33204160(+) A-I      3'UTR chr19:33195957(+) A-I      intronic chr19:33201057(+) A-I      intronic chr19:33191714(+) A-I      intronic chr19:33191481(+) A-I      intronic chr19:33196126(+) A-I      intronic chr19:33196753(+) A-I      intronic chr19:33196771(+) A-I      intronic chr19:33191620(+) A-I      intronic chr19:33191733(+) A-I      intronic chr19:33192857(+) A-I      intronic chr19:33191766(+) A-I      intronic chr19:33192802(+) A-I      intronic chr19:33191598(+) A-I      intronic chr19:33191807(+) A-I      intronic chr19:33196767(+) A-I      intronic chr19:33192796(+) A-I      intronic chr19:33195751(+) A-I      intronic chr19:33192803(+) A-I      intronic chr19:33196207(+) A-I      intronic chr19:33191438(+) A-I      intronic chr19:33200821(+) A-I      intronic chr19:33196608(+) A-I      intronic chr19:33197478(+) A-I      intronic chr19:33196112(+) A-I      intronic chr19:33195919(+) A-I      intronic chr19:33191839(+) A-I      intronic chr19:33191453(+) A-I      intronic chr19:33196141(+) A-I      intronic chr19:33196691(+) A-I      intronic chr19:33191719(+) A-I      intronic chr19:33203425(+) A-I      3'UTR chr19:33192251(+) A-I      intronic chr19:33195915(+) A-I      intronic chr19:33195860(+) A-I      intronic chr19:33191780(+) A-I      intronic chr19:33196096(+) A-I      intronic chr19:33193509(+) A-I      intronic chr19:33198539(+) A-I      intronic chr19:33191488(+) A-I      intronic chr19:33195914(+) A-I      intronic chr19:33203438(+) A-I      3'UTR chr19:33196169(+) A-I      intronic chr19:33196590(+) A-I      intronic chr19:33191736(+) A-I      intronic chr19:33196109(+) A-I      intronic chr19:33196219(+) A-I      intronic chr19:33192212(+) A-I      intronic chr19:33191465(+) A-I      intronic chr19:33196150(+) A-I      intronic chr19:33196632(+) A-I      intronic chr19:33191848(+) A-I      intronic chr19:33196165(+) A-I      intronic chr19:33196765(+) A-I      intronic chr19:33191887(+) A-I      intronic chr19:33196168(+) A-I      intronic chr19:33204167(+) A-I      3'UTR chr19:33201614(+) A-I      intronic chr19:33195456(+) A-I      intronic chr19:33195788(+) A-I      intronic chr19:33186215(+) A-I      intronic chr19:33191898(+) A-I      intronic chr19:33191687(+) A-I      intronic chr19:33204120(+) A-I      3'UTR chr19:33196601(+) A-I      intronic chr19:33195757(+) A-I      intronic chr19:33194145(+) A-I      intronic chr19:33192875(+) A-I      intronic chr19:33192292(+) A-I      intronic chr19:33196287(+) A-I      intronic chr19:33192229(+) A-I      intronic chr19:33196239(+) A-I      intronic chr19:33196242(+) A-I      intronic chr19:33192186(+) A-I      intronic chr19:33197336(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NUDT19	chr19:33191835(+) A-G intron -    22484847 chr19:33192186(+) A-G intron -    22484847 chr19:33192191(+) A-G intron -    22484847 chr19:33192796(+) A-G intron -    22484847 chr19:33192800(+) A-G intron -    22484847 chr19:33192803(+) A-G intron -    22484847 chr19:33195915(+) A-G intron -    22484847 chr19:33196636(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NUDT19	chr19:33183089-33183090(+) m6A CDS       24209618//24981863//27773536//22575960 chr19:33183199-33183200(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:33183298-33183299(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:33183386-33183387(+) m6A CDS       24284625//24209618//24981863//22575960 chr19:33200236-33200237(+) m6A CDS       24981863 chr19:33202684-33202685(+) m6A CDS       24284625//24981863//27773535//22608085 chr19:33202719-33202720(+) m6A CDS       24284625//24981863//27773535//22608085 chr19:33202817-33202818(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr19:33202834-33202835(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr19:33202939-33202940(+) m6A 3'UTR       24981863 chr19:33204385-33204386(+) m6A 3'UTR       27773535 chr19:33204404-33204405(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NUDT19	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART13-3p
Interactor2: NUDT19

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.