Basic Information:

  VIRBase ID:  

VHID00350390

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:  MIMAT0003424          FAM174A:  NM_198507     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART13-3p	FAM174A
miRBase Accession/Entrez ID	MIMAT0003424	345757
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HGS_RE408//NS5ATP6//TMEM157//UNQ1912

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM174A	chr5:99879057(+) A-I      intronic chr5:99879811(+) A-I      intronic chr5:99921283(+) A-I      intronic chr5:99921257(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM174A	chr5:99879032(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM174A	chr5:99871059-99871060(+) m6A 5'UTR       24981863 chr5:99871308-99871309(+) m6A CDS//exon       24284625 chr5:99871380-99871381(+) m6A CDS//exon       24284625 chr5:99871387-99871388(+) m6A CDS//exon       24284625 chr5:99897766-99897767(+) m1A CDS//exon//intron       26863196 chr5:99897771-99897772(+) m6A CDS//exon//intron       24209618 chr5:99897779-99897780(+) m6A CDS//exon//intron       24209618//24981863 chr5:99897801-99897802(+) m6A CDS//exon//intron       24209618//24981863 chr5:99897838-99897839(+) m6A CDS//exon//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM174A	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART13-3p
Interactor2: FAM174A

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).