Detail Information

Basic Information:


  VIRBase ID:  

VHID00350259

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:           SLC41A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART13-3p SLC41A1
miRBase
Accession/Entrez ID		 MIMAT0003424 254428
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - MgtE

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC41A1
chr1:205772018(-) A-I      intronic
chr1:205772034(-) A-I      intronic
chr1:205772040(-) A-I      intronic
chr1:205772031(-) A-I      intronic
chr1:205772886(-) A-I      intronic
chr1:205772908(-) A-I      intronic
chr1:205772879(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC41A1
chr1:205758467-205758468(-) m6A 3'UTR//exon       24981863
chr1:205758507-205758508(-) m6A 3'UTR//exon       24981863
chr1:205758540-205758541(-) m6A 3'UTR//exon       24981863
chr1:205758647-205758648(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr1:205758715-205758716(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr1:205758815-205758816(-) m6A 3'UTR//exon       27773535
chr1:205758844-205758845(-) m6A 3'UTR//exon       27773535
chr1:205758876-205758877(-) m6A 3'UTR//exon       27773535
chr1:205758886-205758887(-) m6A 3'UTR//exon       27773535
chr1:205758897-205758898(-) m6A 3'UTR//exon       27773535
chr1:205758987-205758988(-) m6A 3'UTR//exon       27773535
chr1:205759130-205759131(-) m6A 3'UTR//exon       24981863//27773535
chr1:205759143-205759144(-) m6A 3'UTR//exon       24981863//27773535
chr1:205759281-205759282(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr1:205759417-205759418(-) m6A 3'UTR//exon       27773535
chr1:205759582-205759583(-) m6A 3'UTR//exon       27773535
chr1:205759660-205759661(-) m6A 3'UTR//exon       27773535
chr1:205759683-205759684(-) m6A 3'UTR//exon       27773535
chr1:205760349-205760350(-) m6A 3'UTR//exon       24981863
chr1:205760383-205760384(-) m6A 3'UTR//exon       24981863
chr1:205760430-205760431(-) m6A 3'UTR//exon       24981863
chr1:205760472-205760473(-) m6A 3'UTR//exon       24981863
chr1:205760556-205760557(-) m6A 3'UTR//exon       24981863
chr1:205760664-205760665(-) m6A CDS//exon       24284625//24981863
chr1:205760679-205760680(-) m6A CDS//exon       24284625//24981863
chr1:205760685-205760686(-) m6A CDS//exon       24284625//24981863
chr1:205760742-205760743(-) m6A CDS//exon       24981863
chr1:205760778-205760779(-) m6A CDS//exon       24981863
chr1:205760784-205760785(-) m6A CDS//exon       24981863
chr1:205764527-205764528(-) m6A CDS//exon       24284625
chr1:205768902-205768903(-) m6A CDS//exon       24284625//27773536
chr1:205768938-205768939(-) m6A CDS//exon       24284625//25456834//27773535//27371828//27773536//22608085
chr1:205768946-205768947(-) m6A CDS//exon       24284625//25456834//27773535//27371828//27773536//22608085
chr1:205770117-205770118(-) m6A CDS//exon       24284625//25456834//27773535//27371828//27773536//22608085
chr1:205770456-205770457(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr1:205770584-205770585(-) m6A exon//intron       24284625//24209618//25456834//24981863//22608085
chr1:205770589-205770590(-) m6A exon//intron       24284625//24209618//25456834//24981863//22608085
chr1:205770600-205770601(-) m6A exon//intron       24284625//24209618//25456834//24981863//22608085
chr1:205779207-205779208(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:205779232-205779233(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:205779289-205779290(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:205779324-205779325(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:205779463-205779464(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:205779523-205779524(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:205779653-205779654(-) m6A 5'UTR//exon       24284625//24209618//27773535//27371828
chr1:205779869-205779870(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205779887-205779888(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205779995-205779996(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205780096-205780097(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22608085
chr1:205780183-205780184(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828
chr1:205781991-205781992(-) m6A 5'UTR//intron       24284625//24209618//24981863//27371828
chr1:205782040-205782041(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SLC41A1
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART13-3p
Interactor2: SLC41A1

Evidence Support:


Weak-Evidence HITS-CLIP
Prediction-Evidence cRep//miRanda//PITA//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22473208 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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