Basic Information:

  VIRBase ID:  

VHID00350201

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:  MIMAT0003424          C9orf72:  NM_145005     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART13-3p	C9orf72
miRBase Accession/Entrez ID	MIMAT0003424	203228
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALSFTD//DENND9//DENNL72//FTDALS//FTDALS1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C9orf72	chr9:27571592(-) A-I      intronic chr9:27570753(-) A-I      intronic chr9:27562659(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	C9orf72	chr9:27571488(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C9orf72	chr9:27548281-27548282(-) m6A CDS//exon       24981863//27773535//22608085 chr9:27548311-27548312(-) m6A CDS//exon       24981863//27773535//22608085 chr9:27565582-27565583(-) m6A CDS//exon       22608085 chr9:27566758-27566759(-) m6A CDS//exon       24284625//24209618//24981863//22608085 chr9:27566763-27566764(-) m6A CDS//exon       24284625//24209618//24981863//22608085 chr9:27566785-27566786(-) m6A CDS//exon       24284625//24209618//24981863//22608085 chr9:27566813-27566814(-) m6A CDS//exon       24284625//24209618//24981863//22608085 chr9:27566968-27566969(-) m6A CDS//exon       22608085 chr9:27566973-27566974(-) m6A CDS//exon       22608085 chr9:27567017-27567018(-) m6A CDS//exon       24284625//22608085 chr9:27567075-27567076(-) m6A CDS//exon       24284625//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	C9orf72	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART13-3p
Interactor2: C9orf72

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	cRep//miRanda//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).