Detail Information

Basic Information:


  VIRBase ID:  

VHID00349760

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:           EAF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART13-3p EAF1
miRBase
Accession/Entrez ID		 MIMAT0003424 85403
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EAF1
chr3:15478503(+) A-I      intronic
chr3:15483105(+) A-I      3'UTR
chr3:15483094(+) A-I      3'UTR
chr3:15483134(+) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EAF1
chr3:15469049-15469050(+) m6A 5'UTR       24981863
chr3:15469131-15469132(+) m6A 5'UTR       24981863
chr3:15469143-15469144(+) m6A 5'UTR       24284625//24981863
chr3:15469295-15469296(+) m6A CDS       -
chr3:15469302-15469303(+) m6A CDS       -
chr3:15469314-15469315(+) m6A CDS       -
chr3:15469324-15469325(+) m6A CDS       -
chr3:15473725-15473726(+) m6A CDS//intron       24981863
chr3:15475890-15475891(+) m6A 3'UTR//CDS       24981863//27773535
chr3:15475980-15475981(+) m6A 3'UTR//CDS       24981863//27773535
chr3:15475987-15475988(+) m6A 3'UTR//CDS       24981863//27773535
chr3:15476019-15476020(+) m6A 3'UTR//CDS       24981863//27773535
chr3:15477876-15477877(+) m6A 3'UTR//CDS       27773535
chr3:15477911-15477912(+) m6A 3'UTR//CDS       -
chr3:15477965-15477966(+) m6A 3'UTR//CDS       24209618//24981863
chr3:15478039-15478040(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr3:15478073-15478074(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr3:15480678-15480679(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr3:15480698-15480699(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr3:15480710-15480711(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr3:15480792-15480793(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr3:15480854-15480855(+) m6A 3'UTR       24209618//25456834//24981863//27773535//22608085
chr3:15480882-15480883(+) m6A 3'UTR       24209618//24981863//22608085
chr3:15483144-15483145(+) m6A 3'UTR//intron       25456834
chr3:15483167-15483168(+) m6A 3'UTR//intron       25456834//22608085
chr3:15483209-15483210(+) m6A 3'UTR//intron       25456834//22608085
chr3:15483251-15483252(+) m6A 3'UTR//intron       25456834//22608085
chr3:15483294-15483295(+) m6A 3'UTR//intron       25456834//22608085
chr3:15483324-15483325(+) m6A 3'UTR//intron       25456834
chr3:15483334-15483335(+) m6A 3'UTR//intron       25456834
chr3:15483857-15483858(+) m6A 3'UTR//intron       27773535
chr3:15483885-15483886(+) m6A 3'UTR//intron       27773535
chr3:15483890-15483891(+) m6A 3'UTR//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EAF1
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART13-3p
Interactor2: EAF1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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