Detail Information

Basic Information:


  VIRBase ID:  

VHID00349450

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9617

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:           CAPRIN2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART13-3p CAPRIN2
miRBase
Accession/Entrez ID		 MIMAT0003424 65981
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - C1QDC1//EEG-1//EEG1//RNG140

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CAPRIN2
chr12:30873193(-) A-I      intronic
chr12:30888943(-) A-I      intronic
chr12:30892587(-) A-I      intronic
chr12:30875832(-) A-I      intronic
chr12:30892541(-) A-I      intronic
chr12:30890030(-) A-I      intronic
chr12:30875661(-) A-I      intronic
chr12:30890011(-) A-I      intronic
chr12:30888989(-) A-I      intronic
chr12:30873194(-) A-I      intronic
chr12:30875667(-) A-I      intronic
chr12:30873156(-) A-I      intronic
chr12:30875797(-) A-I      intronic
chr12:30873142(-) A-I      intronic
chr12:30899287(-) A-I      intronic
chr12:30873128(-) A-I      intronic
chr12:30888953(-) A-I      intronic
chr12:30890712(-) A-I      intronic
chr12:30893072(-) A-I      intronic
chr12:30875734(-) A-I      intronic
chr12:30900449(-) A-I      intronic
chr12:30875590(-) A-I      intronic
chr12:30875578(-) A-I      intronic
chr12:30875747(-) A-I      intronic
chr12:30873197(-) A-I      intronic
chr12:30888963(-) A-I      intronic
chr12:30875750(-) A-I      intronic
chr12:30892586(-) A-I      intronic
chr12:30877668(-) A-I      intronic
chr12:30890702(-) A-I      intronic
chr12:30862522(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CAPRIN2
chr12:30864558(-) T-G exon CDS    21725310
chr12:30873146(-) A-T intron -    22484847
chr12:30892586(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CAPRIN2
chr12:30862551-30862552(-) m6A 3'UTR       27773535
chr12:30862926-30862927(-) m6A 3'UTR//CDS       27773535
chr12:30862966-30862967(-) m6A 3'UTR//CDS       27773535//22608085
chr12:30862974-30862975(-) m6A 3'UTR//CDS       27773535//22608085
chr12:30863134-30863135(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085
chr12:30863148-30863149(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085
chr12:30863178-30863179(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085
chr12:30863185-30863186(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085
chr12:30863206-30863207(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085
chr12:30863322-30863323(-) m6A 3'UTR//CDS       24209618//24981863//22608085
chr12:30863330-30863331(-) m6A 3'UTR//CDS       24209618//24981863
chr12:30863353-30863354(-) m6A 3'UTR//CDS       24209618//24981863
chr12:30863361-30863362(-) m6A 3'UTR//CDS       24209618//24981863
chr12:30863407-30863408(-) m6A 3'UTR//CDS//intron       24209618//24981863
chr12:30867992-30867993(-) m6A 3'UTR//CDS//exon       27773535
chr12:30868054-30868055(-) m6A 3'UTR//CDS//exon//intron       27773535
chr12:30868100-30868101(-) m6A 3'UTR//exon//intron       27773535
chr12:30868122-30868123(-) m6A 3'UTR//exon//intron       27773535
chr12:30868483-30868484(-) m6A 3'UTR//intron       27773535
chr12:30868507-30868508(-) m6A 3'UTR//intron       27773535
chr12:30868543-30868544(-) m6A 3'UTR//intron       27773535
chr12:30869466-30869467(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr12:30869504-30869505(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr12:30869571-30869572(-) m6A 3'UTR//CDS//exon       27773535
chr12:30872014-30872015(-) m6A 3'UTR//CDS//exon//intron       27773535
chr12:30872087-30872088(-) m6A 3'UTR//CDS//exon//intron       27773535
chr12:30876237-30876238(-) m6A 3'UTR//CDS//exon       27773535
chr12:30877361-30877362(-) m6A 3'UTR//CDS//exon       27773535
chr12:30878916-30878917(-) m6A 3'UTR//CDS//exon       27773535
chr12:30878947-30878948(-) m6A 3'UTR//CDS//exon       27773535
chr12:30881590-30881591(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr12:30881597-30881598(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr12:30881695-30881696(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:30881714-30881715(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:30881733-30881734(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:30881743-30881744(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:30881755-30881756(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881775-30881776(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881792-30881793(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881797-30881798(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881817-30881818(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881832-30881833(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881851-30881852(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881886-30881887(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881893-30881894(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr12:30881902-30881903(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr12:30882019-30882020(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:30882029-30882030(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:30882034-30882035(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:30882043-30882044(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:30882115-30882116(-) m6A 3'UTR//CDS//exon       24981863//22608085
chr12:30882136-30882137(-) m6A 3'UTR//CDS//exon       22608085
chr12:30882172-30882173(-) m6A 3'UTR//CDS//exon       24981863//22608085
chr12:30882218-30882219(-) m6A 3'UTR//CDS//exon       24981863//22608085
chr12:30884297-30884298(-) m6A 3'UTR//CDS//exon//intron       27773535
chr12:30884312-30884313(-) m6A 3'UTR//CDS//exon//intron       27773535
chr12:30884407-30884408(-) m6A 3'UTR//CDS//exon//intron       27773535
chr12:30884439-30884440(-) m6A 3'UTR//CDS//exon//intron       27773535
chr12:30888033-30888034(-) m6A 3'UTR//CDS//exon       24981863
chr12:30888064-30888065(-) m6A 3'UTR//CDS//exon       24981863
chr12:30888092-30888093(-) m6A CDS//exon       24981863
chr12:30907804-30907805(-) m6A 5'UTR//intron       25456834//27371828//27773536
chr12:30907826-30907827(-) m6A 5'UTR       25456834//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CAPRIN2
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART13-3p
Interactor2: CAPRIN2

Evidence Support:


Strong-Evidence Luciferase reporter assay//Western blot
Weak-Evidence HITS-CLIP//PAR-CLIP
Prediction-Evidence cRep//miRanda//PITA//Rep//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


[1]PMID 22473208 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BJAB cells Interactor2 expression None
Description Sequencing tags overlap a binding site for miR-17 family miRNAs and two BART13-3p sites in the CAPRIN2 3'UTR (Figure 5A). Repression via these sites was confirmed in luciferase assays (Figure 5B-D) and western blot analyses (Figure 5E and F).
[2]PMID 23170179 Target region 3'UTR
Source RepTar//ViRBase Interactor1 expression None
Tissue or cell line BJAB cells Interactor2 expression None
Description Further, HITS-CLIP and PAR-CLIP studies have identified numerous proteins involved in Wnt signaling (CAPRIN2, CTNND1, DAZAP2, CSNK1A1) as targets of KSHV and EBV-encoded miRNAs [20,21,22].

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