Detail Information

Basic Information:


  VIRBase ID:  

VHID00349373

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:           BCORL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART13-3p BCORL1
miRBase
Accession/Entrez ID		 MIMAT0003424 63035
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BCoR-L1//CXorf10//SHUVER

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BCORL1
chrX:129171701(+) A-I      intronic
chrX:129171690(+) A-I      intronic
chrX:129170322(+) A-I      intronic
chrX:129170300(+) A-I      intronic
chrX:129170299(+) A-I      intronic
chrX:129170255(+) A-I      intronic
chrX:129167877(+) A-I      intronic
chrX:129144851(+) A-I      intronic
chrX:129144831(+) A-I      intronic
chrX:129144827(+) A-I      intronic
chrX:129144822(+) A-I      intronic
chrX:129143371(+) A-I      intronic
chrX:129143362(+) A-I      intronic
chrX:129142269(+) A-I      intronic
chrX:129141961(+) A-I      intronic
chrX:129171684(+) A-I      intronic
chrX:129141800(+) A-I      intronic
chrX:129170971(+) A-I      intronic
chrX:129170965(+) A-I      intronic
chrX:129142033(+) A-I      intronic
chrX:129179855(+) A-I      intronic
chrX:129170963(+) A-I      intronic
chrX:129170962(+) A-I      intronic
chrX:129170939(+) A-I      intronic
chrX:129170925(+) A-I      intronic
chrX:129141689(+) A-I      intronic
chrX:129141681(+) A-I      intronic
chrX:129141654(+) A-I      intronic
chrX:129141653(+) A-I      intronic
chrX:129139731(+) A-I      intronic
chrX:129139721(+) A-I      intronic
chrX:129139692(+) A-I      intronic
chrX:129139666(+) A-I      intronic
chrX:129184315(+) A-I      intronic
chrX:129139672(+) A-I      intronic
chrX:129183388(+) A-I      intronic
chrX:129180509(+) A-I      intronic
chrX:129179815(+) A-I      intronic
chrX:129179696(+) A-I      intronic
chrX:129179858(+) A-I      intronic
chrX:129178718(+) A-I      intronic
chrX:129178664(+) A-I      intronic
chrX:129144786(+) A-I      intronic
chrX:129171704(+) A-I      intronic
chrX:129145294(+) A-I      intronic
chrX:129142097(+) A-I      intronic
chrX:129176827(+) A-I      intronic
chrX:129144886(+) A-I      intronic
chrX:129184293(+) A-I      intronic
chrX:129167792(+) A-I      intronic
chrX:129145235(+) A-I      intronic
chrX:129176828(+) A-I      intronic
chrX:129179854(+) A-I      intronic
chrX:129144823(+) A-I      intronic
chrX:129176771(+) A-I      intronic
chrX:129143212(+) A-I      intronic
chrX:129144899(+) A-I      intronic
chrX:129177227(+) A-I      intronic
chrX:129180250(+) A-I      intronic
chrX:129145245(+) A-I      intronic
chrX:129151746(+) A-I      intronic
chrX:129180249(+) A-I      intronic
chrX:129179617(+) A-I      intronic
chrX:129143183(+) A-I      intronic
chrX:129142089(+) A-I      intronic
chrX:129139837(+) A-I      intronic
chrX:129141659(+) A-I      intronic
chrX:129139653(+) A-I      intronic
chrX:129172731(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BCORL1
chrX:129146971-129146972(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chrX:129146996-129146997(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129147016-129147017(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129147046-129147047(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129147171-129147172(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129147197-129147198(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chrX:129147235-129147236(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chrX:129147288-129147289(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129147309-129147310(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129147565-129147566(+) m6A CDS       24284625
chrX:129148068-129148069(+) m6A CDS       24284625
chrX:129148207-129148208(+) m6A CDS       24284625
chrX:129148318-129148319(+) m6A CDS       24284625//24981863
chrX:129148518-129148519(+) m6A CDS       24284625//24981863
chrX:129148527-129148528(+) m6A CDS       24284625//24981863
chrX:129148657-129148658(+) m6A CDS       24284625
chrX:129148668-129148669(+) m6A CDS       24284625
chrX:129148840-129148841(+) m6A CDS       24284625
chrX:129148861-129148862(+) m6A CDS       24284625
chrX:129148939-129148940(+) m6A CDS       24284625//24981863//22575960//22608085
chrX:129148945-129148946(+) m6A CDS       24284625//24981863//22575960//22608085
chrX:129149078-129149079(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chrX:129149142-129149143(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chrX:129149150-129149151(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129149165-129149166(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129149213-129149214(+) m6A CDS       24284625//24981863//22608085
chrX:129149396-129149397(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129149446-129149447(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chrX:129149461-129149462(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chrX:129149466-129149467(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chrX:129149498-129149499(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chrX:129149535-129149536(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chrX:129149541-129149542(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chrX:129149575-129149576(+) m6A CDS       24284625//25456834//24981863//22608085
chrX:129149683-129149684(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129149698-129149699(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129149752-129149753(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129149807-129149808(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129150023-129150024(+) m6A CDS       24284625//24209618//24981863
chrX:129150055-129150056(+) m6A CDS       24284625//24209618//24981863
chrX:129150124-129150125(+) m6A CDS       24284625//24209618//24981863
chrX:129150182-129150183(+) m6A CDS       24284625//24981863
chrX:129158997-129158998(+) m6A CDS//intron       -
chrX:129159086-129159087(+) m6A CDS//intron       24284625//24209618//24981863
chrX:129159096-129159097(+) m6A CDS//intron       24284625//24209618//24981863
chrX:129159126-129159127(+) m6A CDS//intron       24284625//24209618//25456834//24981863
chrX:129159188-129159189(+) m6A CDS//intron       24284625//24209618//25456834//24981863
chrX:129159213-129159214(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chrX:129159237-129159238(+) m1A CDS//intron       26863196
chrX:129159299-129159300(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535
chrX:129162632-129162633(+) m6A CDS       24284625//24981863
chrX:129162669-129162670(+) m6A CDS       24284625//24981863
chrX:129162675-129162676(+) m6A CDS       24284625//24981863
chrX:129162800-129162801(+) m6A CDS       24981863
chrX:129168456-129168457(+) m6A CDS//intron       24981863
chrX:129168488-129168489(+) m6A CDS//intron       24981863
chrX:129168497-129168498(+) m6A CDS//intron       24981863
chrX:129190030-129190031(+) m6A CDS       24284625//25456834//24981863//22608085
chrX:129190058-129190059(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chrX:129190119-129190120(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129190194-129190195(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chrX:129190219-129190220(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chrX:129190262-129190263(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chrX:129190350-129190351(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chrX:129190365-129190366(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chrX:129190411-129190412(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chrX:129190436-129190437(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chrX:129190441-129190442(+) m6A 3'UTR       24284625//25456834//24981863
chrX:129191133-129191134(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BCORL1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART13-3p
Interactor2: BCORL1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//RNAHybrid//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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