Basic Information:

  VIRBase ID:  

VHID00349037

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:  MIMAT0003424          MED9:  NM_018019     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART13-3p	MED9
miRBase Accession/Entrez ID	MIMAT0003424	55090
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	MED25

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MED9	chr17:17382050(+) A-I      intronic chr17:17381992(+) A-I      intronic chr17:17381374(+) A-I      intronic chr17:17387143(+) A-I      intronic chr17:17387172(+) A-I      intronic chr17:17387140(+) A-I      intronic chr17:17387131(+) A-I      intronic chr17:17387130(+) A-I      intronic chr17:17383099(+) A-I      intronic chr17:17382092(+) A-I      intronic chr17:17382091(+) A-I      intronic chr17:17382064(+) A-I      intronic chr17:17382056(+) A-I      intronic chr17:17381422(+) A-I      intronic chr17:17388467(+) A-I      intronic chr17:17387101(+) A-I      intronic chr17:17392155(+) A-I      intronic chr17:17388651(+) A-I      intronic chr17:17388583(+) A-I      intronic chr17:17383031(+) A-I      intronic chr17:17382024(+) A-I      intronic chr17:17381396(+) A-I      intronic chr17:17388445(+) A-I      intronic chr17:17383909(+) A-I      intronic chr17:17382006(+) A-I      intronic chr17:17383021(+) A-I      intronic chr17:17388606(+) A-I      intronic chr17:17381331(+) A-I      intronic chr17:17388412(+) A-I      intronic chr17:17381918(+) A-I      intronic chr17:17388373(+) A-I      intronic chr17:17387089(+) A-I      intronic chr17:17381435(+) A-I      intronic chr17:17386991(+) A-I      intronic chr17:17381410(+) A-I      intronic chr17:17381363(+) A-I      intronic chr17:17381439(+) A-I      intronic chr17:17381484(+) A-I      intronic chr17:17392104(+) A-I      intronic chr17:17382953(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MED9	chr17:17381363(+) A-G intron -    22484847 chr17:17383021(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MED9	chr17:17380696-17380697(+) m6A exon//intron       24209618//25456834 chr17:17380702-17380703(+) m6A exon//intron       24209618//25456834 chr17:17380731-17380732(+) m6A exon//intron       25456834 chr17:17380740-17380741(+) m6A exon//intron       25456834 chr17:17394597-17394598(+) m6A 3'UTR//CDS       - chr17:17394603-17394604(+) m6A 3'UTR//CDS       - chr17:17394624-17394625(+) m6A 3'UTR//CDS       24284625 chr17:17394703-17394704(+) m6A 3'UTR//CDS       24284625//24209618//22575960//22608085 chr17:17394746-17394747(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:17394901-17394902(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr17:17395096-17395097(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr17:17395275-17395276(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr17:17395376-17395377(+) m6A 3'UTR       24284625//22608085 chr17:17395414-17395415(+) m6A 3'UTR       24284625//22608085 chr17:17396130-17396131(+) m6A 3'UTR       24209618//24981863//22608085 chr17:17396170-17396171(+) m6A 3'UTR       24209618//24981863//27773535//22608085 chr17:17396215-17396216(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:17396259-17396260(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:17396276-17396277(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:17396361-17396362(+) m6A 3'UTR       24209618//24981863//22608085 chr17:17396377-17396378(+) m6A 3'UTR       24209618//24981863//22608085 chr17:17396385-17396386(+) m6A 3'UTR       24209618//24981863//22608085 chr17:17396421-17396422(+) m6A 3'UTR       24209618//24981863//22608085 chr17:17396496-17396497(+) m6A 3'UTR       24981863//22608085 chr17:17396512-17396513(+) m6A 3'UTR       24981863//22608085 chr17:17396534-17396535(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MED9	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART13-3p
Interactor2: MED9

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	cRep//miRanda//PITA//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).