Basic Information:

  VIRBase ID:  

VHID00348810

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:  MIMAT0003424          UBQLN1:  NM_053067     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART13-3p	UBQLN1
miRBase Accession/Entrez ID	MIMAT0003424	29979
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DA41//DSK2//PLIC-1//UBQN//XDRP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBQLN1	chr9:86293101(-) A-I      intronic chr9:86312779(-) A-I      intronic chr9:86312678(-) A-I      intronic chr9:86299139(-) A-I      intronic chr9:86298771(-) A-I      intronic chr9:86298745(-) A-I      intronic chr9:86293225(-) A-I      intronic chr9:86299238(-) A-I      intronic chr9:86293075(-) A-I      intronic chr9:86293069(-) A-I      intronic chr9:86292394(-) A-I      intronic chr9:86312461(-) A-I      intronic chr9:86288892(-) A-I      intronic chr9:86299186(-) A-I      intronic chr9:86311471(-) A-I      intronic chr9:86299383(-) A-I      intronic chr9:86299391(-) A-I      intronic chr9:86299482(-) A-I      intronic chr9:86288747(-) A-I      intronic chr9:86299484(-) A-I      intronic chr9:86299563(-) A-I      intronic chr9:86299498(-) A-I      intronic chr9:86299501(-) A-I      intronic chr9:86299510(-) A-I      intronic chr9:86299673(-) A-I      intronic chr9:86288884(-) A-I      intronic chr9:86310284(-) A-I      intronic chr9:86310314(-) A-I      intronic chr9:86288978(-) A-I      intronic chr9:86319679(-) A-I      intronic chr9:86313719(-) A-I      intronic chr9:86311442(-) A-I      intronic chr9:86288887(-) A-I      intronic chr9:86313716(-) A-I      intronic chr9:86320437(-) A-I      intronic chr9:86319678(-) A-I      intronic chr9:86313815(-) A-I      intronic chr9:86313785(-) A-I      intronic chr9:86313783(-) A-I      intronic chr9:86313782(-) A-I      intronic chr9:86313746(-) A-I      intronic chr9:86319647(-) A-I      intronic chr9:86313673(-) A-I      intronic chr9:86299172(-) A-I      intronic chr9:86312883(-) A-I      intronic chr9:86313657(-) A-I      intronic chr9:86313617(-) A-I      intronic chr9:86310216(-) A-I      intronic chr9:86312367(-) A-I      intronic chr9:86320338(-) A-I      intronic chr9:86312821(-) A-I      intronic chr9:86310273(-) A-I      intronic chr9:86319618(-) A-I      intronic chr9:86299303(-) A-I      intronic chr9:86288870(-) A-I      intronic chr9:86312603(-) A-I      intronic chr9:86320422(-) A-I      intronic chr9:86312274(-) A-I      intronic chr9:86319600(-) A-I      intronic chr9:86298138(-) A-I      intronic chr9:86298779(-) A-I      intronic chr9:86311986(-) A-I      intronic chr9:86313571(-) A-I      intronic chr9:86319591(-) A-I      intronic chr9:86313579(-) A-I      intronic chr9:86279642(-) A-I      intronic chr9:86288922(-) A-I      intronic chr9:86288801(-) A-I      intronic chr9:86320253(-) A-I      intronic chr9:86288941(-) A-I      intronic chr9:86288965(-) A-I      intronic chr9:86299618(-) A-I      intronic chr9:86288033(-) A-I      intronic chr9:86312300(-) A-I      intronic chr9:86299717(-) A-I      intronic chr9:86285957(-) A-I      intronic chr9:86319560(-) A-I      intronic chr9:86313745(-) A-I      intronic chr9:86288082(-) A-I      intronic chr9:86277763(-) A-I      intronic chr9:86311954(-) A-I      intronic chr9:86319592(-) A-I      intronic chr9:86310252(-) A-I      intronic chr9:86312556(-) A-I      intronic chr9:86314335(-) A-I      intronic chr9:86298876(-) A-I      intronic chr9:86299248(-) A-I      intronic chr9:86319497(-) A-I      intronic chr9:86303774(-) A-I      intronic chr9:86320425(-) A-I      intronic chr9:86299314(-) A-I      intronic chr9:86319684(-) A-I      intronic chr9:86320302(-) A-I      intronic chr9:86320451(-) A-I      intronic chr9:86320431(-) A-I      intronic chr9:86288881(-) A-I      intronic chr9:86288132(-) A-I      intronic chr9:86320344(-) A-I      intronic chr9:86312355(-) A-I      intronic chr9:86299304(-) A-I      intronic chr9:86297385(-) A-I      intronic chr9:86288397(-) A-I      intronic chr9:86288852(-) A-I      intronic chr9:86319630(-) A-I      intronic chr9:86319697(-) A-I      intronic chr9:86313703(-) A-I      intronic chr9:86312923(-) A-I      intronic chr9:86312283(-) A-I      intronic chr9:86310297(-) A-I      intronic chr9:86287962(-) A-I      intronic chr9:86288061(-) A-I      intronic chr9:86299389(-) A-I      intronic chr9:86312819(-) A-I      intronic chr9:86288820(-) A-I      intronic chr9:86319620(-) A-I      intronic chr9:86312824(-) A-I      intronic chr9:86319568(-) A-I      intronic chr9:86312319(-) A-I      intronic chr9:86299188(-) A-I      intronic chr9:86299470(-) A-I      intronic chr9:86312772(-) A-I      intronic chr9:86288203(-) A-I      intronic chr9:86288877(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBQLN1	chr9:86288855(-) A-G intron -    22484847 chr9:86288922(-) A-G intron -    22484847 chr9:86319491(-) A-G intron -    22484847 chr9:86319497(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBQLN1	chr9:86276068-86276069(-) m6A 3'UTR//exon       26404942 chr9:86276157-86276158(-) m6A 3'UTR//exon       26404942 chr9:86276647-86276648(-) m6A 3'UTR//exon       26404942//22575960 chr9:86276777-86276778(-) m6A CDS//exon       26404942 chr9:86276789-86276790(-) m6A CDS//exon       26404942 chr9:86276815-86276816(-) m6A CDS//exon       26404942 chr9:86278908-86278909(-) m6A CDS//exon       26404942 chr9:86279978-86279979(-) m6A CDS//exon       26404942 chr9:86280025-86280026(-) m6A CDS//exon       26404942 chr9:86280269-86280270(-) m6A exon//intron       24981863 chr9:86281291-86281292(-) m6A CDS//exon//intron       24981863 chr9:86281300-86281301(-) m6A CDS//exon//intron       24981863 chr9:86292764-86292765(-) m6A CDS//exon       26404942 chr9:86293382-86293383(-) m6A CDS//exon       26404942 chr9:86293458-86293459(-) m6A CDS//exon       26404942 chr9:86293464-86293465(-) m6A CDS//exon       26404942 chr9:86293505-86293506(-) m6A CDS//exon       26404942 chr9:86294692-86294693(-) m6A CDS//exon//intron       26404942 chr9:86294782-86294783(-) m6A CDS//exon//intron       26404942 chr9:86322467-86322468(-) m6A CDS       22575960 chr9:86322817-86322818(-) m6A 5'UTR       24209618//25456834//24981863//27371828//22575960//22608085 chr9:86323069-86323070(-) m6A 5'UTR       22608085 chr9:86323076-86323077(-) m6A 5'UTR       22608085 chr9:86323113-86323114(-) m6A 5'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBQLN1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART13-3p
Interactor2: UBQLN1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.