Detail Information

Basic Information:


  VIRBase ID:  

VHID00347703

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART13-3p:           PURB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART13-3p PURB
miRBase
Accession/Entrez ID		 MIMAT0003424 5814
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - PURBETA

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PURB
chr7:44917139(-) A-I      3'UTR
chr7:44917356(-) A-I      3'UTR
chr7:44917340(-) A-I      3'UTR
chr7:44917259(-) A-I      3'UTR
chr7:44918003(-) A-I      3'UTR
chr7:44918670(-) A-I      3'UTR
chr7:44917149(-) A-I      3'UTR
chr7:44917321(-) A-I      3'UTR
chr7:44917143(-) A-I      3'UTR
chr7:44917294(-) A-I      3'UTR
chr7:44918728(-) A-I      3'UTR
chr7:44918736(-) A-I      3'UTR
chr7:44918740(-) A-I      3'UTR
chr7:44918768(-) A-I      3'UTR
chr7:44917157(-) A-I      3'UTR
chr7:44917406(-) A-I      3'UTR
chr7:44917156(-) A-I      3'UTR
chr7:44918804(-) A-I      3'UTR
chr7:44918778(-) A-I      3'UTR
chr7:44917232(-) A-I      3'UTR
chr7:44917320(-) A-I      3'UTR
chr7:44917281(-) A-I      3'UTR
chr7:44918708(-) A-I      3'UTR
chr7:44917158(-) A-I      3'UTR
chr7:44917239(-) A-I      3'UTR
chr7:44917291(-) A-I      3'UTR
chr7:44917145(-) A-I      3'UTR
chr7:44917236(-) A-I      3'UTR
chr7:44917351(-) A-I      3'UTR
chr7:44918898(-) A-I      3'UTR
chr7:44917279(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PURB
chr7:44917232(-) A-I exon 3'UTR    15258596
chr7:44917236(-) A-I exon 3'UTR    15342557   //15258596
chr7:44917239(-) A-I exon 3'UTR    15342557   //15258596
chr7:44917245(-) A-I exon 3'UTR    15258596
chr7:44917278(-) A-I exon 3'UTR    15342557   //15258596
chr7:44917279(-) A-I exon 3'UTR    15342557   //15258596
chr7:44917281(-) A-I exon 3'UTR    15342557   //15258596
chr7:44917291(-) A-I exon 3'UTR    15342557   //15258596
chr7:44917644(-) A-I exon 3'UTR    15342557
chr7:44918899(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PURB
chr7:44915976-44915977(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr7:44916032-44916033(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085
chr7:44916044-44916045(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085
chr7:44916092-44916093(-) m6A 3'UTR       24284625//27773535//27371828//22608085
chr7:44916222-44916223(-) m6A 3'UTR       24284625
chr7:44918735-44918736(-) m6A 3'UTR       24981863
chr7:44918975-44918976(-) m6A 3'UTR       24981863
chr7:44919000-44919001(-) m6A 3'UTR       24981863
chr7:44922308-44922309(-) m6A 3'UTR       24284625
chr7:44922434-44922435(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr7:44922592-44922593(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr7:44922661-44922662(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr7:44922764-44922765(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr7:44922870-44922871(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr7:44922961-44922962(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr7:44922969-44922970(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr7:44923139-44923140(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr7:44923332-44923333(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr7:44923338-44923339(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr7:44923381-44923382(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr7:44923425-44923426(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr7:44923641-44923642(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr7:44923660-44923661(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr7:44923714-44923715(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr7:44923735-44923736(-) Y 3'UTR       26075521
chr7:44923778-44923779(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr7:44923804-44923805(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr7:44923836-44923837(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr7:44923846-44923847(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr7:44923885-44923886(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr7:44924264-44924265(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:44924436-44924437(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr7:44924534-44924535(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr7:44924546-44924547(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr7:44924564-44924565(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr7:44924671-44924672(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr7:44924819-44924820(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr7:44924828-44924829(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PURB
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART13-3p
Interactor2: PURB

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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