Basic Information:

  VIRBase ID:  

VHID00333333

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:  MIMAT0003420          FGD4:  NM_001384132     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART10-3p	FGD4
miRBase Accession/Entrez ID	MIMAT0003420	121512
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CMT4H//FRABP//ZFYVE6

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FGD4	chr12:32703533(+) A-I      intronic chr12:32703520(+) A-I      intronic chr12:32691913(+) A-I      intronic chr12:32691909(+) A-I      intronic chr12:32691908(+) A-I      intronic chr12:32691894(+) A-I      intronic chr12:32691881(+) A-I      intronic chr12:32691877(+) A-I      intronic chr12:32763382(+) A-I      intronic chr12:32798453(+) A-I      3'UTR chr12:32763379(+) A-I      intronic chr12:32798472(+) A-I      3'UTR chr12:32763381(+) A-I      intronic chr12:32798477(+) A-I      3'UTR chr12:32798518(+) A-I      3'UTR chr12:32763354(+) A-I      intronic chr12:32763345(+) A-I      intronic chr12:32763335(+) A-I      intronic chr12:32747915(+) A-I      intronic chr12:32760290(+) A-I      intronic chr12:32760548(+) A-I      intronic chr12:32673450(+) A-I      intronic chr12:32731375(+) A-I      intronic chr12:32731373(+) A-I      intronic chr12:32731372(+) A-I      intronic chr12:32706836(+) A-I      intronic chr12:32726236(+) A-I      intronic chr12:32731509(+) A-I      intronic chr12:32731614(+) A-I      intronic chr12:32740554(+) A-I      intronic chr12:32740547(+) A-I      intronic chr12:32740466(+) A-I      intronic chr12:32740418(+) A-I      intronic chr12:32797973(+) A-I      3'UTR chr12:32798463(+) A-I      3'UTR chr12:32724334(+) A-I      intronic chr12:32691867(+) A-I      intronic chr12:32723125(+) A-I      intronic chr12:32691873(+) A-I      intronic chr12:32723120(+) A-I      intronic chr12:32723116(+) A-I      intronic chr12:32723096(+) A-I      intronic chr12:32723087(+) A-I      intronic chr12:32723081(+) A-I      intronic chr12:32723064(+) A-I      intronic chr12:32703559(+) A-I      intronic chr12:32703546(+) A-I      intronic chr12:32697244(+) A-I      intronic chr12:32697296(+) A-I      intronic chr12:32786818(+) A-I      intronic chr12:32786801(+) A-I      intronic chr12:32697314(+) A-I      intronic chr12:32697560(+) A-I      intronic chr12:32740508(+) A-I      intronic chr12:32784543(+) A-I      intronic chr12:32784539(+) A-I      intronic chr12:32740534(+) A-I      intronic chr12:32697647(+) A-I      intronic chr12:32743103(+) A-I      intronic chr12:32760537(+) A-I      intronic chr12:32760274(+) A-I      intronic chr12:32700299(+) A-I      intronic chr12:32700860(+) A-I      intronic chr12:32760232(+) A-I      intronic chr12:32700908(+) A-I      intronic chr12:32743111(+) A-I      intronic chr12:32743119(+) A-I      intronic chr12:32703592(+) A-I      intronic chr12:32784519(+) A-I      intronic chr12:32706919(+) A-I      intronic chr12:32708610(+) A-I      intronic chr12:32784503(+) A-I      intronic chr12:32745117(+) A-I      intronic chr12:32723452(+) A-I      intronic chr12:32783720(+) A-I      intronic chr12:32723456(+) A-I      intronic chr12:32723462(+) A-I      intronic chr12:32723469(+) A-I      intronic chr12:32723609(+) A-I      intronic chr12:32783702(+) A-I      intronic chr12:32723618(+) A-I      intronic chr12:32724210(+) A-I      intronic chr12:32750896(+) A-I      intronic chr12:32724211(+) A-I      intronic chr12:32754839(+) A-I      intronic chr12:32724242(+) A-I      intronic chr12:32783691(+) A-I      intronic chr12:32724243(+) A-I      intronic chr12:32724304(+) A-I      intronic chr12:32724309(+) A-I      intronic chr12:32783656(+) A-I      intronic chr12:32724317(+) A-I      intronic chr12:32774108(+) A-I      intronic chr12:32724924(+) A-I      intronic chr12:32724956(+) A-I      intronic chr12:32731605(+) A-I      intronic chr12:32731606(+) A-I      intronic chr12:32754840(+) A-I      intronic chr12:32731608(+) A-I      intronic chr12:32732042(+) A-I      intronic chr12:32732055(+) A-I      intronic chr12:32760632(+) A-I      intronic chr12:32732127(+) A-I      intronic chr12:32732164(+) A-I      intronic chr12:32760629(+) A-I      intronic chr12:32732212(+) A-I      intronic chr12:32732240(+) A-I      intronic chr12:32737976(+) A-I      intronic chr12:32760588(+) A-I      intronic chr12:32754928(+) A-I      intronic chr12:32738081(+) A-I      intronic chr12:32738793(+) A-I      intronic chr12:32739905(+) A-I      intronic chr12:32739929(+) A-I      intronic chr12:32739948(+) A-I      intronic chr12:32760547(+) A-I      intronic chr12:32739954(+) A-I      intronic chr12:32739966(+) A-I      intronic chr12:32760544(+) A-I      intronic chr12:32740081(+) A-I      intronic chr12:32740094(+) A-I      intronic chr12:32740499(+) A-I      intronic chr12:32667469(+) A-I      intronic chr12:32667549(+) A-I      intronic chr12:32667886(+) A-I      intronic chr12:32667903(+) A-I      intronic chr12:32790409(+) A-I      intronic chr12:32787760(+) A-I      intronic chr12:32677271(+) A-I      intronic chr12:32677577(+) A-I      intronic chr12:32677620(+) A-I      intronic chr12:32682656(+) A-I      intronic chr12:32787714(+) A-I      intronic chr12:32682666(+) A-I      intronic chr12:32682670(+) A-I      intronic chr12:32754934(+) A-I      intronic chr12:32738794(+) A-I      intronic chr12:32665260(+) A-I      intronic chr12:32789320(+) A-I      intronic chr12:32786837(+) A-I      intronic chr12:32740429(+) A-I      intronic chr12:32737916(+) A-I      intronic chr12:32732050(+) A-I      intronic chr12:32738042(+) A-I      intronic chr12:32745060(+) A-I      intronic chr12:32738606(+) A-I      intronic chr12:32703456(+) A-I      intronic chr12:32669299(+) A-I      intronic chr12:32736137(+) A-I      intronic chr12:32774094(+) A-I      intronic chr12:32774054(+) A-I      intronic chr12:32786798(+) A-I      intronic chr12:32760280(+) A-I      intronic chr12:32737993(+) A-I      intronic chr12:32778356(+) A-I      intronic chr12:32786757(+) A-I      intronic chr12:32672035(+) A-I      intronic chr12:32700718(+) A-I      intronic chr12:32740442(+) A-I      intronic chr12:32723048(+) A-I      intronic chr12:32740560(+) A-I      intronic chr12:32731715(+) A-I      intronic chr12:32738589(+) A-I      intronic chr12:32683369(+) A-I      intronic chr12:32745073(+) A-I      intronic chr12:32738647(+) A-I      intronic chr12:32750920(+) A-I      intronic chr12:32780287(+) A-I      intronic chr12:32731673(+) A-I      intronic chr12:32723061(+) A-I      intronic chr12:32798601(+) A-I      3'UTR chr12:32798575(+) A-I      3'UTR chr12:32798471(+) A-I      3'UTR chr12:32798574(+) A-I      3'UTR chr12:32756882(+) A-I      intronic chr12:32740411(+) A-I      intronic chr12:32665293(+) A-I      intronic chr12:32732147(+) A-I      intronic chr12:32709973(+) A-I      intronic chr12:32682630(+) A-I      intronic chr12:32774053(+) A-I      intronic chr12:32752743(+) A-I      intronic chr12:32683374(+) A-I      intronic chr12:32723597(+) A-I      intronic chr12:32781581(+) A-I      intronic chr12:32732037(+) A-I      intronic chr12:32740425(+) A-I      intronic chr12:32750963(+) A-I      intronic chr12:32788825(+) A-I      intronic chr12:32750934(+) A-I      intronic chr12:32783678(+) A-I      intronic chr12:32732252(+) A-I      intronic chr12:32774131(+) A-I      intronic chr12:32723013(+) A-I      intronic chr12:32731699(+) A-I      intronic chr12:32722999(+) A-I      intronic chr12:32781477(+) A-I      intronic chr12:32665261(+) A-I      intronic chr12:32691095(+) A-I      intronic chr12:32743086(+) A-I      intronic chr12:32745040(+) A-I      intronic chr12:32731617(+) A-I      intronic chr12:32724224(+) A-I      intronic chr12:32703490(+) A-I      intronic chr12:32740065(+) A-I      intronic chr12:32665333(+) A-I      intronic chr12:32684027(+) A-I      intronic chr12:32773806(+) A-I      intronic chr12:32732261(+) A-I      intronic chr12:32779862(+) A-I      intronic chr12:32781478(+) A-I      intronic chr12:32774047(+) A-I      intronic chr12:32697410(+) A-I      intronic chr12:32723399(+) A-I      intronic chr12:32669330(+) A-I      intronic chr12:32674142(+) A-I      intronic chr12:32723643(+) A-I      intronic chr12:32783531(+) A-I      intronic chr12:32667860(+) A-I      intronic chr12:32740428(+) A-I      intronic chr12:32786878(+) A-I      intronic chr12:32783532(+) A-I      intronic chr12:32724941(+) A-I      intronic chr12:32779838(+) A-I      intronic chr12:32790423(+) A-I      intronic chr12:32780362(+) A-I      intronic chr12:32664326(+) A-I      intronic chr12:32740424(+) A-I      intronic chr12:32723031(+) A-I      intronic chr12:32674249(+) A-I      intronic chr12:32731730(+) A-I      intronic chr12:32724268(+) A-I      intronic chr12:32783507(+) A-I      intronic chr12:32731413(+) A-I      intronic chr12:32740559(+) A-I      intronic chr12:32778378(+) A-I      intronic chr12:32699272(+) A-I      intronic chr12:32724352(+) A-I      intronic chr12:32738045(+) A-I      intronic chr12:32740577(+) A-I      intronic chr12:32709984(+) A-I      intronic chr12:32779121(+) A-I      intronic chr12:32779915(+) A-I      intronic chr12:32752413(+) A-I      intronic chr12:32681599(+) A-I      intronic chr12:32750860(+) A-I      intronic chr12:32783670(+) A-I      intronic chr12:32740402(+) A-I      intronic chr12:32731371(+) A-I      intronic chr12:32671990(+) A-I      intronic chr12:32667546(+) A-I      intronic chr12:32737945(+) A-I      intronic chr12:32731500(+) A-I      intronic chr12:32745146(+) A-I      intronic chr12:32705490(+) A-I      intronic chr12:32783529(+) A-I      intronic chr12:32775007(+) A-I      intronic chr12:32783869(+) A-I      intronic chr12:32774133(+) A-I      intronic chr12:32697489(+) A-I      intronic chr12:32703422(+) A-I      intronic chr12:32750924(+) A-I      intronic chr12:32731625(+) A-I      intronic chr12:32703419(+) A-I      intronic chr12:32774150(+) A-I      intronic chr12:32738728(+) A-I      intronic chr12:32722989(+) A-I      intronic chr12:32738009(+) A-I      intronic chr12:32783867(+) A-I      intronic chr12:32736160(+) A-I      intronic chr12:32773794(+) A-I      intronic chr12:32740490(+) A-I      intronic chr12:32724310(+) A-I      intronic chr12:32749748(+) A-I      intronic chr12:32667532(+) A-I      intronic chr12:32745182(+) A-I      intronic chr12:32731409(+) A-I      intronic chr12:32738688(+) A-I      intronic chr12:32723100(+) A-I      intronic chr12:32731530(+) A-I      intronic chr12:32709605(+) A-I      intronic chr12:32740017(+) A-I      intronic chr12:32760469(+) A-I      intronic chr12:32779306(+) A-I      intronic chr12:32739960(+) A-I      intronic chr12:32783494(+) A-I      intronic chr12:32781471(+) A-I      intronic chr12:32783341(+) A-I      intronic chr12:32732110(+) A-I      intronic chr12:32677504(+) A-I      intronic chr12:32783785(+) A-I      intronic chr12:32691094(+) A-I      intronic chr12:32732161(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FGD4	chr12:32730471(+) A-I intron -    21960545 chr12:32780199(+) C-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FGD4	chr12:32552638-32552639(+) m6A 5'UTR       25456834 chr12:32734937-32734938(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863//22608085 chr12:32734954-32734955(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:32734995-32734996(+) m6A 5'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735044-32735045(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:32735059-32735060(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:32735093-32735094(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:32735160-32735161(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735203-32735204(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735234-32735235(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735272-32735273(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735320-32735321(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735326-32735327(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735367-32735368(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735381-32735382(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735413-32735414(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr12:32735434-32735435(+) m6A 3'UTR//exon//intron       25456834//24981863 chr12:32793276-32793277(+) m6A 3'UTR//CDS       25456834//24981863//22608085 chr12:32793295-32793296(+) m6A 3'UTR//CDS       25456834//24981863//22608085 chr12:32793333-32793334(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr12:32793343-32793344(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr12:32793392-32793393(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//22608085 chr12:32793442-32793443(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//22608085 chr12:32793467-32793468(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793478-32793479(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793504-32793505(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793518-32793519(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793594-32793595(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr12:32793676-32793677(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FGD4	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART10-3p
Interactor2: FGD4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.