Basic Information:

  VIRBase ID:  

VHID00332926

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:  MIMAT0003420          COPS7B:  NM_022730     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART10-3p	COPS7B
miRBase Accession/Entrez ID	MIMAT0003420	64708
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CSN7B//SGN7b

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	COPS7B	chr2:232657055(+) A-I      intronic chr2:232669775(+) A-I      intronic chr2:232671159(+) A-I      intronic chr2:232671147(+) A-I      intronic chr2:232671182(+) A-I      intronic chr2:232669794(+) A-I      intronic chr2:232669802(+) A-I      intronic chr2:232670559(+) A-I      intronic chr2:232657016(+) A-I      intronic chr2:232657051(+) A-I      intronic chr2:232669770(+) A-I      intronic chr2:232670510(+) A-I      intronic chr2:232671183(+) A-I      intronic chr2:232657134(+) A-I      intronic chr2:232671226(+) A-I      intronic chr2:232669788(+) A-I      intronic chr2:232670452(+) A-I      intronic chr2:232671132(+) A-I      intronic chr2:232659517(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	COPS7B	chr2:232659517(+) A-G intron -    22484847 chr2:232666340(+) C-T intron -    22484847 chr2:232669770(+) A-G intron -    22484847 chr2:232669802(+) A-G intron -    22484847 chr2:232670307(+) A-G intron -    22484847 chr2:232671133(+) A-G intron -    22484847 chr2:232671156(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	COPS7B	chr2:232646418-232646419(+) m6A 5'UTR//exon       24981863 chr2:232646454-232646455(+) m6A 5'UTR//exon       24981863 chr2:232646490-232646491(+) m6A 5'UTR//exon       24981863 chr2:232646497-232646498(+) m6A 5'UTR//exon       24981863 chr2:232646510-232646511(+) m6A 5'UTR//exon       24981863 chr2:232646571-232646572(+) m6A 5'UTR//CDS//exon       25456834//24981863 chr2:232646577-232646578(+) m6A 5'UTR//CDS//exon       25456834//24981863 chr2:232651141-232651142(+) m6A 5'UTR//intron       25456834//24981863 chr2:232651227-232651228(+) m6A 5'UTR//exon//intron       24209618//25456834//24981863//22608085 chr2:232651244-232651245(+) m6A 5'UTR//exon//intron       24209618//25456834//24981863//22608085 chr2:232653291-232653292(+) m6A 5'UTR//CDS//exon//intron       24209618//25456834//24981863//22608085 chr2:232653297-232653298(+) m6A 5'UTR//CDS//exon//intron       24209618//25456834//24981863//22608085 chr2:232656403-232656404(+) m6A exon//intron       - chr2:232656422-232656423(+) m6A exon//intron       - chr2:232656482-232656483(+) m6A 3'UTR//CDS//exon//intron       - chr2:232656499-232656500(+) m6A 3'UTR//CDS//exon//intron       - chr2:232656544-232656545(+) m6A exon//intron       - chr2:232661004-232661005(+) m6A 3'UTR//CDS//exon       - chr2:232663639-232663640(+) m6A 3'UTR//CDS//exon       - chr2:232663650-232663651(+) m6A 3'UTR//CDS//exon       - chr2:232672214-232672215(+) m6A 3'UTR//CDS//exon       - chr2:232672406-232672407(+) m6A 3'UTR//exon//intron       24284625 chr2:232672453-232672454(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr2:232672508-232672509(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr2:232672558-232672559(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr2:232672588-232672589(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr2:232672598-232672599(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr2:232672778-232672779(+) Y 3'UTR//exon//intron       26075521 chr2:232673149-232673150(+) m6A 3'UTR//CDS//exon       24284625 chr2:232673245-232673246(+) m6A 3'UTR//CDS//exon       24284625//25456834 chr2:232673332-232673333(+) m6A 3'UTR//exon       24284625//25456834//24981863 chr2:232673342-232673343(+) m6A 3'UTR//exon       25456834//24981863 chr2:232673350-232673351(+) m6A 3'UTR//exon       25456834//24981863 chr2:232673356-232673357(+) m6A 3'UTR//exon       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	COPS7B	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART10-3p
Interactor2: COPS7B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BCBL-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.