Basic Information:

  VIRBase ID:  

VHID00332910

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:  MIMAT0003420          LMBR1:  NR_146958     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART10-3p	LMBR1
miRBase Accession/Entrez ID	MIMAT0003420	64327
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACHP//C7orf2//DIF14//LSS//PPD2//THYP//TPT//ZRS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LMBR1	chr7:156502710(-) A-I      intronic chr7:156502696(-) A-I      intronic chr7:156487800(-) A-I      intronic chr7:156487799(-) A-I      intronic chr7:156580883(-) A-I      intronic chr7:156633543(-) A-I      intronic chr7:156580653(-) A-I      intronic chr7:156505496(-) A-I      intronic chr7:156580650(-) A-I      intronic chr7:156580641(-) A-I      intronic chr7:156580638(-) A-I      intronic chr7:156636902(-) A-I      intronic chr7:156636906(-) A-I      intronic chr7:156638971(-) A-I      intronic chr7:156648749(-) A-I      intronic chr7:156660706(-) A-I      intronic chr7:156660948(-) A-I      intronic chr7:156660999(-) A-I      intronic chr7:156580635(-) A-I      intronic chr7:156575963(-) A-I      intronic chr7:156575958(-) A-I      intronic chr7:156575948(-) A-I      intronic chr7:156525575(-) A-I      intronic chr7:156575494(-) A-I      intronic chr7:156575273(-) A-I      intronic chr7:156567480(-) A-I      intronic chr7:156563004(-) A-I      intronic chr7:156562963(-) A-I      intronic chr7:156661602(-) A-I      intronic chr7:156525831(-) A-I      intronic chr7:156525590(-) A-I      intronic chr7:156562950(-) A-I      intronic chr7:156673602(-) A-I      intronic chr7:156673550(-) A-I      intronic chr7:156673529(-) A-I      intronic chr7:156549756(-) A-I      intronic chr7:156549689(-) A-I      intronic chr7:156542552(-) A-I      intronic chr7:156542551(-) A-I      intronic chr7:156525833(-) A-I      intronic chr7:156636467(-) A-I      intronic chr7:156673526(-) A-I      intronic chr7:156673525(-) A-I      intronic chr7:156673439(-) A-I      intronic chr7:156672246(-) A-I      intronic chr7:156672236(-) A-I      intronic chr7:156672191(-) A-I      intronic chr7:156661564(-) A-I      intronic chr7:156661008(-) A-I      intronic chr7:156580163(-) A-I      intronic chr7:156580175(-) A-I      intronic chr7:156580178(-) A-I      intronic chr7:156683790(-) A-I      intronic chr7:156580724(-) A-I      intronic chr7:156633537(-) A-I      intronic chr7:156617431(-) A-I      intronic chr7:156617364(-) A-I      intronic chr7:156608972(-) A-I      intronic chr7:156608968(-) A-I      intronic chr7:156525825(-) A-I      intronic chr7:156525633(-) A-I      intronic chr7:156522339(-) A-I      intronic chr7:156522279(-) A-I      intronic chr7:156522264(-) A-I      intronic chr7:156521765(-) A-I      intronic chr7:156521694(-) A-I      intronic chr7:156521682(-) A-I      intronic chr7:156521666(-) A-I      intronic chr7:156511345(-) A-I      intronic chr7:156511336(-) A-I      intronic chr7:156511280(-) A-I      intronic chr7:156503999(-) A-I      intronic chr7:156503921(-) A-I      intronic chr7:156503840(-) A-I      intronic chr7:156503831(-) A-I      intronic chr7:156503815(-) A-I      intronic chr7:156608895(-) A-I      intronic chr7:156607790(-) A-I      intronic chr7:156607774(-) A-I      intronic chr7:156607666(-) A-I      intronic chr7:156604216(-) A-I      intronic chr7:156603709(-) A-I      intronic chr7:156603708(-) A-I      intronic chr7:156603193(-) A-I      intronic chr7:156603192(-) A-I      intronic chr7:156680860(-) A-I      intronic chr7:156681102(-) A-I      intronic chr7:156603172(-) A-I      intronic chr7:156581660(-) A-I      intronic chr7:156581633(-) A-I      intronic chr7:156580899(-) A-I      intronic chr7:156503783(-) A-I      intronic chr7:156502763(-) A-I      intronic chr7:156502755(-) A-I      intronic chr7:156502718(-) A-I      intronic chr7:156607639(-) A-I      intronic chr7:156607787(-) A-I      intronic chr7:156661219(-) A-I      intronic chr7:156522296(-) A-I      intronic chr7:156562986(-) A-I      intronic chr7:156683628(-) A-I      intronic chr7:156522332(-) A-I      intronic chr7:156580631(-) A-I      intronic chr7:156581634(-) A-I      intronic chr7:156580961(-) A-I      intronic chr7:156581630(-) A-I      intronic chr7:156680982(-) A-I      intronic chr7:156681041(-) A-I      intronic chr7:156681057(-) A-I      intronic chr7:156680937(-) A-I      intronic chr7:156609040(-) A-I      intronic chr7:156680946(-) A-I      intronic chr7:156609038(-) A-I      intronic chr7:156521757(-) A-I      intronic chr7:156525672(-) A-I      intronic chr7:156588490(-) A-I      intronic chr7:156525593(-) A-I      intronic chr7:156521569(-) A-I      intronic chr7:156680992(-) A-I      intronic chr7:156603163(-) A-I      intronic chr7:156563436(-) A-I      intronic chr7:156525634(-) A-I      intronic chr7:156680960(-) A-I      intronic chr7:156680915(-) A-I      intronic chr7:156633464(-) A-I      intronic chr7:156605889(-) A-I      intronic chr7:156604182(-) A-I      intronic chr7:156525655(-) A-I      intronic chr7:156680940(-) A-I      intronic chr7:156502845(-) A-I      intronic chr7:156609069(-) A-I      intronic chr7:156616697(-) A-I      intronic chr7:156609037(-) A-I      intronic chr7:156522362(-) A-I      intronic chr7:156523567(-) A-I      intronic chr7:156580705(-) A-I      intronic chr7:156509771(-) A-I      intronic chr7:156561025(-) A-I      intronic chr7:156618811(-) A-I      intronic chr7:156661313(-) A-I      intronic chr7:156603678(-) A-I      intronic chr7:156521562(-) A-I      intronic chr7:156522439(-) A-I      intronic chr7:156631946(-) A-I      intronic chr7:156560801(-) A-I      intronic chr7:156502794(-) A-I      intronic chr7:156486965(-) A-I      intronic chr7:156673484(-) A-I      intronic chr7:156521810(-) A-I      intronic chr7:156603669(-) A-I      intronic chr7:156523578(-) A-I      intronic chr7:156629761(-) A-I      intronic chr7:156661025(-) A-I      intronic chr7:156661244(-) A-I      intronic chr7:156604256(-) A-I      intronic chr7:156521797(-) A-I      intronic chr7:156525800(-) A-I      intronic chr7:156560975(-) A-I      intronic chr7:156661195(-) A-I      intronic chr7:156605854(-) A-I      intronic chr7:156502737(-) A-I      intronic chr7:156672169(-) A-I      intronic chr7:156511428(-) A-I      intronic chr7:156604221(-) A-I      intronic chr7:156507828(-) A-I      intronic chr7:156630731(-) A-I      intronic chr7:156607634(-) A-I      intronic chr7:156521824(-) A-I      intronic chr7:156502836(-) A-I      intronic chr7:156541258(-) A-I      intronic chr7:156607630(-) A-I      intronic chr7:156651691(-) A-I      intronic chr7:156521672(-) A-I      intronic chr7:156660985(-) A-I      intronic chr7:156638957(-) A-I      intronic chr7:156507724(-) A-I      intronic chr7:156549690(-) A-I      intronic chr7:156617508(-) A-I      intronic chr7:156567940(-) A-I      intronic chr7:156525808(-) A-I      intronic chr7:156638417(-) A-I      intronic chr7:156569693(-) A-I      intronic chr7:156680071(-) A-I      intronic chr7:156646608(-) A-I      intronic chr7:156660990(-) A-I      intronic chr7:156605895(-) A-I      intronic chr7:156549791(-) A-I      intronic chr7:156631947(-) A-I      intronic chr7:156521737(-) A-I      intronic chr7:156525727(-) A-I      intronic chr7:156604191(-) A-I      intronic chr7:156503928(-) A-I      intronic chr7:156577924(-) A-I      intronic chr7:156588363(-) A-I      intronic chr7:156580960(-) A-I      intronic chr7:156521570(-) A-I      intronic chr7:156522448(-) A-I      intronic chr7:156569715(-) A-I      intronic chr7:156607767(-) A-I      intronic chr7:156580911(-) A-I      intronic chr7:156523548(-) A-I      intronic chr7:156502833(-) A-I      intronic chr7:156521793(-) A-I      intronic chr7:156680075(-) A-I      intronic chr7:156523376(-) A-I      intronic chr7:156503837(-) A-I      intronic chr7:156580743(-) A-I      intronic chr7:156503941(-) A-I      intronic chr7:156609064(-) A-I      intronic chr7:156509738(-) A-I      intronic chr7:156487887(-) A-I      intronic chr7:156638386(-) A-I      intronic chr7:156525635(-) A-I      intronic chr7:156661048(-) A-I      intronic chr7:156554571(-) A-I      intronic chr7:156603579(-) A-I      intronic chr7:156608996(-) A-I      intronic chr7:156661281(-) A-I      intronic chr7:156580959(-) A-I      intronic chr7:156549693(-) A-I      intronic chr7:156607768(-) A-I      intronic chr7:156542602(-) A-I      intronic chr7:156503895(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LMBR1	chr7:156680915(-) A-I intron -    22028664 chr7:156680937(-) A-I intron -    22028664 chr7:156680940(-) A-I intron -    22028664 chr7:156680946(-) A-I intron -    22028664 chr7:156680960(-) A-I intron -    22028664 chr7:156680982(-) A-I intron -    22028664 chr7:156680992(-) A-I intron -    22028664 chr7:156681041(-) A-I intron -    22028664 chr7:156681057(-) A-I intron -    22028664 chr7:156505306(-) A-G intron -    22484847 chr7:156512927(-) A-G intron -    22484847 chr7:156631346(-) A-G intron -    22484847 chr7:156487996(-) A-G intron -    22484847 chr7:156502836(-) A-G intron -    22484847 chr7:156502845(-) A-G intron -    22484847 chr7:156503837(-) A-G intron -    22484847 chr7:156503895(-) A-G intron -    22484847 chr7:156503928(-) A-G intron -    22484847 chr7:156509771(-) A-G intron -    22484847 chr7:156521569(-) A-G intron -    22484847 chr7:156521570(-) A-G intron -    22484847 chr7:156521662(-) A-G intron -    22484847 chr7:156521672(-) A-G intron -    22484847 chr7:156521737(-) A-G intron -    22484847 chr7:156521757(-) A-G intron -    22484847 chr7:156521824(-) A-G intron -    22484847 chr7:156522306(-) A-G intron -    22484847 chr7:156522332(-) A-G intron -    22484847 chr7:156522362(-) A-G intron -    22484847 chr7:156525800(-) A-G intron -    22484847 chr7:156525808(-) A-G intron -    22484847 chr7:156542602(-) A-G intron -    22484847 chr7:156542620(-) A-G intron -    22484847 chr7:156549693(-) A-G intron -    22484847 chr7:156549713(-) A-G intron -    22484847 chr7:156554571(-) A-G intron -    22484847 chr7:156554670(-) G-T intron -    22484847 chr7:156563436(-) A-G intron -    22484847 chr7:156580631(-) A-G intron -    22484847 chr7:156580643(-) T-C intron -    22484847 chr7:156580677(-) G-C intron -    22484847 chr7:156580705(-) A-G intron -    22484847 chr7:156580718(-) A-G intron -    22484847 chr7:156580743(-) A-G intron -    22484847 chr7:156580763(-) A-G intron -    22484847 chr7:156580908(-) A-G intron -    22484847 chr7:156580911(-) A-G intron -    22484847 chr7:156580959(-) A-G intron -    22484847 chr7:156580960(-) A-G intron -    22484847 chr7:156581630(-) A-G intron -    22484847 chr7:156581634(-) A-G intron -    22484847 chr7:156581735(-) A-G intron -    22484847 chr7:156588490(-) A-G intron -    22484847 chr7:156603669(-) A-G intron -    22484847 chr7:156603674(-) A-G intron -    22484847 chr7:156604191(-) A-G intron -    22484847 chr7:156604221(-) A-G intron -    22484847 chr7:156604256(-) A-G intron -    22484847 chr7:156607728(-) A-G intron -    22484847 chr7:156607767(-) A-G intron -    22484847 chr7:156607768(-) A-G intron -    22484847 chr7:156607787(-) A-G intron -    22484847 chr7:156608976(-) A-G intron -    22484847 chr7:156608997(-) A-G intron -    22484847 chr7:156609064(-) A-G intron -    22484847 chr7:156616595(-) A-G intron -    22484847 chr7:156616697(-) A-G intron -    22484847 chr7:156618811(-) A-G intron -    22484847 chr7:156631946(-) A-G intron -    22484847 chr7:156631947(-) A-G intron -    22484847 chr7:156638386(-) A-G intron -    22484847 chr7:156638957(-) A-G intron -    22484847 chr7:156646543(-) G-A intron -    22484847 chr7:156659400(-) T-A intron -    22484847 chr7:156660985(-) A-G intron -    22484847 chr7:156660990(-) A-G intron -    22484847 chr7:156661281(-) A-G intron -    22484847 chr7:156661348(-) A-G intron -    22484847 chr7:156672169(-) A-G intron -    22484847 chr7:156673484(-) A-G intron -    22484847 chr7:156673485(-) A-G intron -    22484847 chr7:156673620(-) A-G intron -    22484847 chr7:156680071(-) A-G intron -    22484847 chr7:156680075(-) A-G intron -    22484847 chr7:156680082(-) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LMBR1	chr7:156461776-156461777(-) m6A exon       27773535 chr7:156461915-156461916(-) m6A exon       27371828 chr7:156461945-156461946(-) m6A exon       27371828//22608085 chr7:156469005-156469006(-) m6A exon//intron       24284625//25456834//24981863//27371828//27773536//22608085 chr7:156469020-156469021(-) m6A exon//intron       24284625//25456834//24981863//27371828//27773536//22608085 chr7:156469035-156469036(-) m6A exon//intron       24284625//25456834//24981863//27371828//27773536//22608085 chr7:156469047-156469048(-) m6A exon//intron       24284625//25456834//24981863//27371828//27773536//22608085 chr7:156469220-156469221(-) m6A exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:156469235-156469236(-) m6A exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr7:156469249-156469250(-) m6A exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr7:156469268-156469269(-) m6A exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr7:156469303-156469304(-) m6A exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr7:156470676-156470677(-) m6A 3'UTR//exon//intron       25456834//27773535//22608085 chr7:156470716-156470717(-) m6A 3'UTR//exon//intron       27773535//22608085 chr7:156470866-156470867(-) m6A 3'UTR//exon//intron       27773535 chr7:156473034-156473035(-) m6A 3'UTR//intron       27773535 chr7:156473176-156473177(-) m6A 3'UTR//exon       27773535 chr7:156473239-156473240(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27773536//22608085 chr7:156473261-156473262(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27773536//22608085 chr7:156473266-156473267(-) m6A 3'UTR//exon       27773535//22608085 chr7:156473297-156473298(-) m6A 3'UTR//intron       22608085 chr7:156473490-156473491(-) m6A 3'UTR//intron       27773535 chr7:156474271-156474272(-) m6A 3'UTR//intron       24284625//27773535 chr7:156474451-156474452(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr7:156474515-156474516(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr7:156474570-156474571(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr7:156474630-156474631(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr7:156474722-156474723(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr7:156474739-156474740(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:156474746-156474747(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:156474854-156474855(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:156474911-156474912(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:156476423-156476424(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr7:156476431-156476432(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr7:156476511-156476512(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr7:156476530-156476531(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr7:156476539-156476540(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr7:156476576-156476577(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr7:156476619-156476620(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr7:156476657-156476658(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:156476663-156476664(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:156476730-156476731(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:156476738-156476739(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085 chr7:156476812-156476813(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr7:156476846-156476847(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr7:156480739-156480740(-) m6A 3'UTR//CDS//intron       24284625 chr7:156685262-156685263(-) m6A exon//intron       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LMBR1	Chromatin HCC cell line (HepG2)|K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART10-3p
Interactor2: LMBR1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.