Basic Information:

  VIRBase ID:  

VHID00332804

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:  MIMAT0003420          HECW2:  NM_001348768     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART10-3p	HECW2
miRBase Accession/Entrez ID	MIMAT0003420	57520
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	NDHSAL//NEDL2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HECW2	chr2:197122916(-) A-I      intronic chr2:197171394(-) A-I      intronic chr2:197100578(-) A-I      intronic chr2:197100579(-) A-I      intronic chr2:197119789(-) A-I      intronic chr2:197100588(-) A-I      intronic chr2:197119799(-) A-I      intronic chr2:197119794(-) A-I      intronic chr2:197119793(-) A-I      intronic chr2:197100632(-) A-I      intronic chr2:197119782(-) A-I      intronic chr2:197100623(-) A-I      intronic chr2:197119735(-) A-I      intronic chr2:197119733(-) A-I      intronic chr2:197100577(-) A-I      intronic chr2:197100648(-) A-I      intronic chr2:197119933(-) A-I      intronic chr2:197266813(-) A-I      intronic chr2:197266735(-) A-I      intronic chr2:197263652(-) A-I      intronic chr2:197249799(-) A-I      intronic chr2:197263647(-) A-I      intronic chr2:197276733(-) A-I      intronic chr2:197275843(-) A-I      intronic chr2:197275825(-) A-I      intronic chr2:197272198(-) A-I      intronic chr2:197272049(-) A-I      intronic chr2:197266911(-) A-I      intronic chr2:197266878(-) A-I      intronic chr2:197266868(-) A-I      intronic chr2:197266849(-) A-I      intronic chr2:197266843(-) A-I      intronic chr2:197249761(-) A-I      intronic chr2:197249646(-) A-I      intronic chr2:197241623(-) A-I      intronic chr2:197130122(-) A-I      intronic chr2:197130087(-) A-I      intronic chr2:197130085(-) A-I      intronic chr2:197224090(-) A-I      intronic chr2:197214979(-) A-I      intronic chr2:197212035(-) A-I      intronic chr2:197212034(-) A-I      intronic chr2:197211956(-) A-I      intronic chr2:197211675(-) A-I      intronic chr2:197211646(-) A-I      intronic chr2:197211588(-) A-I      intronic chr2:197130061(-) A-I      intronic chr2:197276634(-) A-I      intronic chr2:197276626(-) A-I      intronic chr2:197130127(-) A-I      intronic chr2:197130204(-) A-I      intronic chr2:197134060(-) A-I      intronic chr2:197137889(-) A-I      intronic chr2:197147771(-) A-I      intronic chr2:197130046(-) A-I      intronic chr2:197130004(-) A-I      intronic chr2:197129965(-) A-I      intronic chr2:197127401(-) A-I      intronic chr2:197120633(-) A-I      intronic chr2:197111888(-) A-I      intronic chr2:197111866(-) A-I      intronic chr2:197111822(-) A-I      intronic chr2:197111793(-) A-I      intronic chr2:197111765(-) A-I      intronic chr2:197111730(-) A-I      intronic chr2:197111351(-) A-I      intronic chr2:197111319(-) A-I      intronic chr2:197108482(-) A-I      intronic chr2:197108409(-) A-I      intronic chr2:197108389(-) A-I      intronic chr2:197108367(-) A-I      intronic chr2:197108317(-) A-I      intronic chr2:197096605(-) A-I      intronic chr2:197096604(-) A-I      intronic chr2:197096601(-) A-I      intronic chr2:197096591(-) A-I      intronic chr2:197096478(-) A-I      intronic chr2:197096468(-) A-I      intronic chr2:197276622(-) A-I      intronic chr2:197147874(-) A-I      intronic chr2:197134127(-) A-I      intronic chr2:197336951(-) A-I      intronic chr2:197148238(-) A-I      intronic chr2:197086497(-) A-I      intronic chr2:197336949(-) A-I      intronic chr2:197120710(-) A-I      intronic chr2:197111233(-) A-I      intronic chr2:197249102(-) A-I      intronic chr2:197249887(-) A-I      intronic chr2:197099150(-) A-I      intronic chr2:197377643(-) A-I      intronic chr2:197405332(-) A-I      intronic chr2:197126950(-) A-I      intronic chr2:197406820(-) A-I      intronic chr2:197148211(-) A-I      intronic chr2:197130093(-) A-I      intronic chr2:197249171(-) A-I      intronic chr2:197332897(-) A-I      intronic chr2:197269687(-) A-I      intronic chr2:197134061(-) A-I      intronic chr2:197147864(-) A-I      intronic chr2:197405456(-) A-I      intronic chr2:197263642(-) A-I      intronic chr2:197119942(-) A-I      intronic chr2:197267668(-) A-I      intronic chr2:197278243(-) A-I      intronic chr2:197377589(-) A-I      intronic chr2:197074662(-) A-I      intronic chr2:197377595(-) A-I      intronic chr2:197119870(-) A-I      intronic chr2:197212160(-) A-I      intronic chr2:197267782(-) A-I      intronic chr2:197147891(-) A-I      intronic chr2:197211481(-) A-I      intronic chr2:197130123(-) A-I      intronic chr2:197360062(-) A-I      intronic chr2:197119962(-) A-I      intronic chr2:197337484(-) A-I      intronic chr2:197074656(-) A-I      intronic chr2:197437044(-) A-I      intronic chr2:197272075(-) A-I      intronic chr2:197108109(-) A-I      intronic chr2:197120715(-) A-I      intronic chr2:197431288(-) A-I      intronic chr2:197312764(-) A-I      intronic chr2:197120666(-) A-I      intronic chr2:197083320(-) A-I      intronic chr2:197074603(-) A-I      intronic chr2:197267734(-) A-I      intronic chr2:197408533(-) A-I      intronic chr2:197275861(-) A-I      intronic chr2:197111343(-) A-I      intronic chr2:197249917(-) A-I      intronic chr2:197377598(-) A-I      intronic chr2:197276732(-) A-I      intronic chr2:197111349(-) A-I      intronic chr2:197119988(-) A-I      intronic chr2:197099986(-) A-I      intronic chr2:197211610(-) A-I      intronic chr2:197100103(-) A-I      intronic chr2:197120711(-) A-I      intronic chr2:197249855(-) A-I      intronic chr2:197211914(-) A-I      intronic chr2:197377629(-) A-I      intronic chr2:197249120(-) A-I      intronic chr2:197278234(-) A-I      intronic chr2:197249157(-) A-I      intronic chr2:197214831(-) A-I      intronic chr2:197276001(-) A-I      intronic chr2:197283124(-) A-I      intronic chr2:197427672(-) A-I      intronic chr2:197120685(-) A-I      intronic chr2:197120673(-) A-I      intronic chr2:197267730(-) A-I      intronic chr2:197332907(-) A-I      intronic chr2:197148206(-) A-I      intronic chr2:197316511(-) A-I      intronic chr2:197437149(-) A-I      intronic chr2:197249835(-) A-I      intronic chr2:197120667(-) A-I      intronic chr2:197377313(-) A-I      intronic chr2:197120720(-) A-I      intronic chr2:197276625(-) A-I      intronic chr2:197316501(-) A-I      intronic chr2:197377213(-) A-I      intronic chr2:197119989(-) A-I      intronic chr2:197135537(-) A-I      intronic chr2:197211645(-) A-I      intronic chr2:197329608(-) A-I      intronic chr2:197074667(-) A-I      intronic chr2:197148363(-) A-I      intronic chr2:197263621(-) A-I      intronic chr2:197148237(-) A-I      intronic chr2:197211543(-) A-I      intronic chr2:197146132(-) A-I      intronic chr2:197277929(-) A-I      intronic chr2:197111867(-) A-I      intronic chr2:197111247(-) A-I      intronic chr2:197433954(-) A-I      intronic chr2:197148202(-) A-I      intronic chr2:197431385(-) A-I      intronic chr2:197147817(-) A-I      intronic chr2:197436384(-) A-I      intronic chr2:197406823(-) A-I      intronic chr2:197136301(-) A-I      intronic chr2:197377578(-) A-I      intronic chr2:197446239(-) A-I      intronic chr2:197111273(-) A-I      intronic chr2:197119918(-) A-I      intronic chr2:197111348(-) A-I      intronic chr2:197267682(-) A-I      intronic chr2:197406743(-) A-I      intronic chr2:197135542(-) A-I      intronic chr2:197119983(-) A-I      intronic chr2:197405205(-) A-I      intronic chr2:197377280(-) A-I      intronic chr2:197211474(-) A-I      intronic chr2:197111768(-) A-I      intronic chr2:197275932(-) A-I      intronic chr2:197096565(-) A-I      intronic chr2:197083319(-) A-I      intronic chr2:197249117(-) A-I      intronic chr2:197135522(-) A-I      intronic chr2:197111209(-) A-I      intronic chr2:197249791(-) A-I      intronic chr2:197136384(-) A-I      intronic chr2:197431368(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HECW2	chr2:197119908(-) A-I intron -    15342557 chr2:197119927(-) A-I intron -    15342557 chr2:197119942(-) A-I intron -    15342557 chr2:197119962(-) A-I intron -    15342557 chr2:197119983(-) A-I intron -    15342557 chr2:197119988(-) A-I intron -    15342557 chr2:197119989(-) A-I intron -    15342557 chr2:197120546(-) A-I intron -    15342557 chr2:197120592(-) A-I intron -    15342557 chr2:197120662(-) A-I intron -    15342557 chr2:197120666(-) A-I intron -    15342557 chr2:197120667(-) A-I intron -    15342557 chr2:197120673(-) A-I intron -    15342557 chr2:197120685(-) A-I intron -    15342557 chr2:197120688(-) A-I intron -    15342557 chr2:197120697(-) A-I intron -    15342557 chr2:197120710(-) A-I intron -    15342557 chr2:197120711(-) A-I intron -    15342557 chr2:197120714(-) A-I intron -    15342557 chr2:197120715(-) A-I intron -    15342557 chr2:197120720(-) A-I intron -    15342557 chr2:197120728(-) A-I intron -    15342557 chr2:197083319(-) A-G intron -    22484847 chr2:197086464(-) A-T intron -    22484847 chr2:197096456(-) A-G intron -    22484847 chr2:197111233(-) A-G intron -    22484847 chr2:197111241(-) A-G intron -    22484847 chr2:197111247(-) A-G intron -    22484847 chr2:197111273(-) A-G intron -    22484847 chr2:197111343(-) A-G intron -    22484847 chr2:197111348(-) A-G intron -    22484847 chr2:197111349(-) A-G intron -    22484847 chr2:197111768(-) A-G intron -    22484847 chr2:197111892(-) A-G intron -    22484847 chr2:197120711(-) A-G intron -    22484847 chr2:197134043(-) A-G intron -    22484847 chr2:197134061(-) A-G intron -    22484847 chr2:197134126(-) A-G intron -    22484847 chr2:197134127(-) A-G intron -    22484847 chr2:197140474(-) A-T intron -    22484847 chr2:197147795(-) A-G intron -    22484847 chr2:197147817(-) A-G intron -    22484847 chr2:197147820(-) A-G intron -    22484847 chr2:197147864(-) A-G intron -    22484847 chr2:197147891(-) A-G intron -    22484847 chr2:197148202(-) A-G intron -    22484847 chr2:197148206(-) A-G intron -    22484847 chr2:197148238(-) A-G intron -    22484847 chr2:197148363(-) A-G intron -    22484847 chr2:197164480(-) G-A intron -    22484847 chr2:197211474(-) A-G intron -    22484847 chr2:197211480(-) A-G intron -    22484847 chr2:197211481(-) A-G intron -    22484847 chr2:197211543(-) A-G intron -    22484847 chr2:197211610(-) A-G intron -    22484847 chr2:197211645(-) A-G intron -    22484847 chr2:197211914(-) A-G intron -    22484847 chr2:197211915(-) A-G intron -    22484847 chr2:197212079(-) A-G intron -    22484847 chr2:197212231(-) A-G intron -    22484847 chr2:197224804(-) T-C intron -    22484847 chr2:197249102(-) A-G intron -    22484847 chr2:197249117(-) A-G intron -    22484847 chr2:197249120(-) A-G intron -    22484847 chr2:197249157(-) A-G intron -    22484847 chr2:197249171(-) A-G intron -    22484847 chr2:197249182(-) A-G intron -    22484847 chr2:197249265(-) A-G intron -    22484847 chr2:197249733(-) A-G intron -    22484847 chr2:197249792(-) A-G intron -    22484847 chr2:197249835(-) A-G intron -    22484847 chr2:197249855(-) A-G intron -    22484847 chr2:197249887(-) A-G intron -    22484847 chr2:197249917(-) A-G intron -    22484847 chr2:197263621(-) A-G intron -    22484847 chr2:197263642(-) A-G intron -    22484847 chr2:197267730(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HECW2	chr2:197064040-197064041(-) m6A 3'UTR       27773535 chr2:197065356-197065357(-) m6A 3'UTR       27773535 chr2:197065448-197065449(-) m6A 3'UTR       27773535 chr2:197065465-197065466(-) m6A 3'UTR       27773535 chr2:197065634-197065635(-) m6A 3'UTR       24981863//27773535//22608085 chr2:197065662-197065663(-) m6A 3'UTR       24981863//27773535//22608085 chr2:197065680-197065681(-) m6A 3'UTR       24981863//28052920//27773535//22608085 chr2:197065716-197065717(-) m6A 3'UTR       24209618//25456834//24981863//28052920//27773535//22608085 chr2:197065726-197065727(-) m6A 3'UTR       24209618//25456834//24981863//28052920//27773535//22608085 chr2:197065752-197065753(-) m6A 3'UTR       24209618//25456834//24981863//28052920//27773535//22608085 chr2:197065793-197065794(-) m6A 3'UTR       24209618//25456834//24981863//28052920//27773535//22608085 chr2:197065844-197065845(-) m6A 3'UTR       24209618//25456834//24981863//28052920//27773535//22608085 chr2:197065868-197065869(-) m6A 3'UTR       24209618//25456834//24981863//28052920//27773535//22608085 chr2:197065931-197065932(-) m6A 3'UTR       25456834//24981863//27773535//22608085 chr2:197065971-197065972(-) m6A 3'UTR       24981863//22608085 chr2:197066009-197066010(-) m6A CDS       24981863//22608085 chr2:197066023-197066024(-) m6A CDS       24981863//22608085 chr2:197066045-197066046(-) m6A CDS       24209618//24981863//22608085 chr2:197084782-197084783(-) m6A CDS       27773535 chr2:197084800-197084801(-) m6A CDS       27773535 chr2:197084835-197084836(-) m6A CDS       27773535 chr2:197085547-197085548(-) m6A CDS       24981863 chr2:197085609-197085610(-) m6A CDS       24981863 chr2:197086971-197086972(-) m6A CDS       27773535 chr2:197086995-197086996(-) m6A CDS       27773535 chr2:197143314-197143315(-) m6A CDS//exon       24981863 chr2:197183643-197183644(-) m6A CDS       25456834 chr2:197183749-197183750(-) m6A CDS       25456834//24981863//28052920//27773536//22608085 chr2:197183768-197183769(-) m6A CDS       25456834//24981863//28052920//27773536//22608085 chr2:197183773-197183774(-) m6A CDS       25456834//24981863//28052920//27773536//22608085 chr2:197183821-197183822(-) m6A CDS       24209618//25456834//24981863//27773536//22608085 chr2:197183863-197183864(-) m6A CDS       24209618//25456834//24981863//27773536//22608085 chr2:197183871-197183872(-) m6A CDS       24209618//25456834//24981863//27773536//22608085 chr2:197183915-197183916(-) m6A CDS       24209618//24981863//22608085 chr2:197184189-197184190(-) m6A CDS       - chr2:197184245-197184246(-) m6A CDS       24981863//22608085 chr2:197184275-197184276(-) m6A CDS       25456834//24981863//22608085 chr2:197184316-197184317(-) m6A CDS       25456834//24981863//28052920//22608085 chr2:197184341-197184342(-) m6A CDS       24209618//25456834//24981863//28052920//22608085 chr2:197184397-197184398(-) m6A CDS       24981863//22608085 chr2:197184429-197184430(-) m6A CDS       24981863//22608085 chr2:197184451-197184452(-) m6A CDS       24981863//22608085 chr2:197184472-197184473(-) m6A CDS       24981863//22608085 chr2:197184489-197184490(-) m6A CDS       24981863//22608085 chr2:197184546-197184547(-) m6A 5'UTR//CDS       24981863 chr2:197184573-197184574(-) m6A 5'UTR//CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HECW2	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART10-3p
Interactor2: HECW2

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	cRep//miRanda//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).