Detail Information

Basic Information:


  VIRBase ID:  

VHID00332779

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:           PBXIP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART10-3p PBXIP1
miRBase
Accession/Entrez ID		 MIMAT0003420 57326
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - HPIP

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PBXIP1
chr1:154926888(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PBXIP1
chr1:154916630-154916631(-) m6A 3'UTR       27773535
chr1:154917064-154917065(-) m6A 3'UTR       -
chr1:154917318-154917319(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr1:154917423-154917424(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr1:154917578-154917579(-) m6A CDS       24209618//24981863//27773535//27371828//27773536
chr1:154918065-154918066(-) m6A CDS       24209618//27773535//27371828//27773536
chr1:154918092-154918093(-) m6A CDS       24209618//27773535//27371828//27773536
chr1:154918126-154918127(-) m6A CDS       27773535//27371828
chr1:154918155-154918156(-) m6A CDS       27773535//27371828
chr1:154918288-154918289(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536
chr1:154918452-154918453(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22608085
chr1:154918459-154918460(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22608085
chr1:154918529-154918530(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr1:154918620-154918621(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr1:154918638-154918639(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr1:154918642-154918643(-) m1A CDS       26863196
chr1:154918672-154918673(-) Am CDS       -
chr1:154918676-154918677(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr1:154918698-154918699(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr1:154918803-154918804(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536
chr1:154918815-154918816(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536
chr1:154918832-154918833(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536
chr1:154918881-154918882(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536
chr1:154918994-154918995(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536
chr1:154919018-154919019(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536
chr1:154919605-154919606(-) m6A 3'UTR//intron       24209618//27371828//27773536
chr1:154919676-154919677(-) m6A 3'UTR//intron       27371828//27773536
chr1:154919920-154919921(-) m6A CDS//exon       24209618
chr1:154919926-154919927(-) m6A CDS//exon       24209618
chr1:154919944-154919945(-) m6A CDS//exon       24209618//27773536
chr1:154919962-154919963(-) m6A CDS//exon       24209618//27773536
chr1:154920009-154920010(-) m6A CDS//exon       24284625//24209618//27773536
chr1:154920124-154920125(-) m6A CDS//exon       24284625//24209618//27773536
chr1:154920151-154920152(-) m6A 3'UTR//CDS//exon       24209618//27773536
chr1:154920460-154920461(-) m6A 3'UTR//CDS//exon       24209618//27773536
chr1:154920712-154920713(-) m6A 3'UTR//CDS//exon       24209618//27371828//27773536
chr1:154920787-154920788(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535//27371828//27773536
chr1:154923757-154923758(-) m6A CDS//exon       24284625//24209618//27773535//27371828//27773536
chr1:154923766-154923767(-) m6A CDS//exon       24284625//24209618//27773535//27371828//27773536
chr1:154923771-154923772(-) m6A CDS//exon       24284625//24209618//27773535//27371828//27773536
chr1:154923794-154923795(-) m6A CDS//exon       24284625//24209618//27773535//27371828//27773536
chr1:154923805-154923806(-) m6A CDS//exon       24284625//24209618//27773535//27371828//27773536
chr1:154923823-154923824(-) m6A CDS//exon       24284625//24209618//27773535//27371828//27773536
chr1:154923957-154923958(-) m6A CDS//exon       24284625//24209618//27773535
chr1:154923996-154923997(-) m6A CDS//exon       24284625//27773535
chr1:154924076-154924077(-) m6A exon//intron       27773535
chr1:154924143-154924144(-) m6A exon//intron       27773535
chr1:154924285-154924286(-) m6A CDS//exon//intron       24284625//27773535//27371828
chr1:154924309-154924310(-) m6A CDS//exon//intron       24284625//27773535//27371828
chr1:154924356-154924357(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828
chr1:154924381-154924382(-) m6A 5'UTR//CDS//exon//intron       24284625//24981863//27773535//27371828
chr1:154926180-154926181(-) m6A CDS//exon//intron       24284625//24981863//27371828
chr1:154926208-154926209(-) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27371828
chr1:154928565-154928566(-) m6A 5'UTR       24284625//24981863//26404942//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PBXIP1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART10-3p
Interactor2: PBXIP1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

Starting a new search, please wait ...