Basic Information:

  VIRBase ID:  

VHID00332692

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:  MIMAT0003420          MBNL3:  NM_001386891     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART10-3p	MBNL3
miRBase Accession/Entrez ID	MIMAT0003420	55796
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHCR//MBLX//MBLX39//MBXL

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MBNL3	chrX:131568981(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MBNL3	chrX:131503521-131503522(-) m6A 3'UTR       27773535//22608085 chrX:131503527-131503528(-) m6A 3'UTR       27773535//22575960//22608085 chrX:131503611-131503612(-) m6A 3'UTR       27773535//22575960//22608085 chrX:131503666-131503667(-) m6A 3'UTR       27773535//22608085 chrX:131503671-131503672(-) m6A 3'UTR       27773535//22608085 chrX:131503689-131503690(-) m6A 3'UTR       27773535//22608085 chrX:131503842-131503843(-) m6A 3'UTR       27773535 chrX:131503848-131503849(-) m6A 3'UTR       27773535 chrX:131503893-131503894(-) m6A 3'UTR       27773535 chrX:131507461-131507462(-) m6A 3'UTR       27773535 chrX:131513561-131513562(-) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MBNL3	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART10-3p
Interactor2: MBNL3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.