Basic Information:

  VIRBase ID:  

VHID00332669

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:  MIMAT0003420          MREG:  NM_018000     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART10-3p	MREG
miRBase Accession/Entrez ID	MIMAT0003420	55686
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DSU//WDT2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MREG	chr2:216809006(-) A-I      3'UTR chr2:216833536(-) A-I      intronic chr2:216824950(-) A-I      intronic chr2:216825324(-) A-I      intronic chr2:216825369(-) A-I      intronic chr2:216852036(-) A-I      intronic chr2:216825377(-) A-I      intronic chr2:216825419(-) A-I      intronic chr2:216861722(-) A-I      intronic chr2:216861700(-) A-I      intronic chr2:216852513(-) A-I      intronic chr2:216852498(-) A-I      intronic chr2:216852488(-) A-I      intronic chr2:216852486(-) A-I      intronic chr2:216852424(-) A-I      intronic chr2:216852359(-) A-I      intronic chr2:216852118(-) A-I      intronic chr2:216852094(-) A-I      intronic chr2:216852054(-) A-I      intronic chr2:216852037(-) A-I      intronic chr2:216833733(-) A-I      intronic chr2:216833689(-) A-I      intronic chr2:216833683(-) A-I      intronic chr2:216833544(-) A-I      intronic chr2:216833514(-) A-I      intronic chr2:216825448(-) A-I      intronic chr2:216829124(-) A-I      intronic chr2:216825449(-) A-I      intronic chr2:216825481(-) A-I      intronic chr2:216814039(-) A-I      intronic chr2:216875719(-) A-I      intronic chr2:216875775(-) A-I      intronic chr2:216814048(-) A-I      intronic chr2:216814065(-) A-I      intronic chr2:216814172(-) A-I      intronic chr2:216824741(-) A-I      intronic chr2:216875772(-) A-I      intronic chr2:216824881(-) A-I      intronic chr2:216875743(-) A-I      intronic chr2:216875707(-) A-I      intronic chr2:216870277(-) A-I      intronic chr2:216829160(-) A-I      intronic chr2:216870260(-) A-I      intronic chr2:216870210(-) A-I      intronic chr2:216861723(-) A-I      intronic chr2:216824817(-) A-I      intronic chr2:216824848(-) A-I      intronic chr2:216824873(-) A-I      intronic chr2:216825564(-) A-I      intronic chr2:216824904(-) A-I      intronic chr2:216808395(-) A-I      3'UTR chr2:216808856(-) A-I      3'UTR chr2:216808897(-) A-I      3'UTR chr2:216808935(-) A-I      3'UTR chr2:216808763(-) A-I      3'UTR chr2:216808415(-) A-I      3'UTR chr2:216808351(-) A-I      3'UTR chr2:216808383(-) A-I      3'UTR chr2:216808910(-) A-I      3'UTR chr2:216808322(-) A-I      3'UTR chr2:216808922(-) A-I      3'UTR chr2:216808368(-) A-I      3'UTR chr2:216808921(-) A-I      3'UTR chr2:216852587(-) A-I      intronic chr2:216831596(-) A-I      intronic chr2:216826422(-) A-I      intronic chr2:216870272(-) A-I      intronic chr2:216825470(-) A-I      intronic chr2:216869254(-) A-I      intronic chr2:216825435(-) A-I      intronic chr2:216852477(-) A-I      intronic chr2:216813721(-) A-I      intronic chr2:216852514(-) A-I      intronic chr2:216829144(-) A-I      intronic chr2:216827602(-) A-I      intronic chr2:216825302(-) A-I      intronic chr2:216827667(-) A-I      intronic chr2:216808907(-) A-I      3'UTR chr2:216808750(-) A-I      3'UTR chr2:216808840(-) A-I      3'UTR chr2:216808841(-) A-I      3'UTR chr2:216808397(-) A-I      3'UTR chr2:216808879(-) A-I      3'UTR chr2:216808755(-) A-I      3'UTR chr2:216808481(-) A-I      3'UTR chr2:216808299(-) A-I      3'UTR chr2:216808526(-) A-I      3'UTR chr2:216808528(-) A-I      3'UTR chr2:216808873(-) A-I      3'UTR chr2:216808872(-) A-I      3'UTR chr2:216808811(-) A-I      3'UTR chr2:216808320(-) A-I      3'UTR chr2:216808330(-) A-I      3'UTR chr2:216808321(-) A-I      3'UTR chr2:216808464(-) A-I      3'UTR chr2:216808477(-) A-I      3'UTR chr2:216808800(-) A-I      3'UTR chr2:216808416(-) A-I      3'UTR chr2:216808502(-) A-I      3'UTR chr2:216808699(-) A-I      3'UTR chr2:216808880(-) A-I      3'UTR chr2:216808881(-) A-I      3'UTR chr2:216808712(-) A-I      3'UTR chr2:216808831(-) A-I      3'UTR chr2:216808827(-) A-I      3'UTR chr2:216808440(-) A-I      3'UTR chr2:216808982(-) A-I      3'UTR chr2:216808375(-) A-I      3'UTR chr2:216808876(-) A-I      3'UTR chr2:216808406(-) A-I      3'UTR chr2:216808808(-) A-I      3'UTR chr2:216808482(-) A-I      3'UTR chr2:216808452(-) A-I      3'UTR chr2:216808898(-) A-I      3'UTR chr2:216808442(-) A-I      3'UTR chr2:216808882(-) A-I      3'UTR chr2:216808308(-) A-I      3'UTR chr2:216808501(-) A-I      3'UTR chr2:216808957(-) A-I      3'UTR chr2:216808973(-) A-I      3'UTR chr2:216824843(-) A-I      intronic chr2:216831325(-) A-I      intronic chr2:216824712(-) A-I      intronic chr2:216824807(-) A-I      intronic chr2:216825475(-) A-I      intronic chr2:216872404(-) A-I      intronic chr2:216825505(-) A-I      intronic chr2:216825409(-) A-I      intronic chr2:216852510(-) A-I      intronic chr2:216813939(-) A-I      intronic chr2:216869253(-) A-I      intronic chr2:216824776(-) A-I      intronic chr2:216824883(-) A-I      intronic chr2:216872255(-) A-I      intronic chr2:216829176(-) A-I      intronic chr2:216870280(-) A-I      intronic chr2:216826423(-) A-I      intronic chr2:216821462(-) A-I      intronic chr2:216852544(-) A-I      intronic chr2:216828002(-) A-I      intronic chr2:216827599(-) A-I      intronic chr2:216875575(-) A-I      intronic chr2:216821297(-) A-I      intronic chr2:216824907(-) A-I      intronic chr2:216813669(-) A-I      intronic chr2:216870271(-) A-I      intronic chr2:216833681(-) A-I      intronic chr2:216869220(-) A-I      intronic chr2:216852259(-) A-I      intronic chr2:216852504(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MREG	chr2:216808308(-) A-I exon 3'UTR    22327324 chr2:216808320(-) A-I exon 3'UTR    22327324 chr2:216808375(-) A-I exon 3'UTR    22327324 chr2:216808400(-) A-I exon 3'UTR    22327324 chr2:216808406(-) A-I exon 3'UTR    22327324 chr2:216808481(-) A-I exon 3'UTR    22327324 chr2:216808840(-) A-I exon 3'UTR    21960545   //22327324 chr2:216808841(-) A-I exon 3'UTR    21960545   //22327324 chr2:216808867(-) A-I exon 3'UTR    22327324 chr2:216808882(-) A-I exon 3'UTR    22327324 chr2:216808906(-) A-I exon 3'UTR    22327324 chr2:216808973(-) A-I exon 3'UTR    22327324 chr2:216808974(-) A-I exon 3'UTR    21960545 chr2:216851352(-) A-G intron -    22484847 chr2:216808308(-) A-G exon 3'UTR    22484847 chr2:216808320(-) A-G exon 3'UTR    22484847 chr2:216808321(-) A-G exon 3'UTR    22484847 chr2:216808330(-) A-G exon 3'UTR    22484847 chr2:216808375(-) A-G exon 3'UTR    22484847 chr2:216808400(-) A-G exon 3'UTR    22484847 chr2:216808406(-) A-G exon 3'UTR    22484847 chr2:216808416(-) A-G exon 3'UTR    22484847 chr2:216808440(-) A-G exon 3'UTR    22484847 chr2:216808442(-) A-G exon 3'UTR    22484847 chr2:216808445(-) A-G exon 3'UTR    22484847 chr2:216808452(-) A-G exon 3'UTR    22484847 chr2:216808477(-) A-G exon 3'UTR    22484847 chr2:216808481(-) A-G exon 3'UTR    22484847 chr2:216808482(-) A-G exon 3'UTR    22484847 chr2:216808502(-) A-G exon 3'UTR    22484847 chr2:216808526(-) A-G exon 3'UTR    22484847 chr2:216808561(-) G-T exon 3'UTR    22484847 chr2:216808755(-) A-G exon 3'UTR    22484847 chr2:216808781(-) A-G exon 3'UTR    22484847 chr2:216808800(-) A-G exon 3'UTR    22484847 chr2:216808811(-) A-G exon 3'UTR    22484847 chr2:216808827(-) A-G exon 3'UTR    22484847 chr2:216808831(-) A-G exon 3'UTR    22484847 chr2:216808835(-) A-G exon 3'UTR    22484847 chr2:216808840(-) A-G exon 3'UTR    22484847 chr2:216808841(-) A-G exon 3'UTR    22484847 chr2:216808863(-) A-G exon 3'UTR    22484847 chr2:216808867(-) A-G exon 3'UTR    22484847 chr2:216808873(-) A-G exon 3'UTR    22484847 chr2:216808876(-) A-G exon 3'UTR    22484847 chr2:216808878(-) A-G exon 3'UTR    22484847 chr2:216808879(-) A-G exon 3'UTR    22484847 chr2:216808880(-) A-G exon 3'UTR    22484847 chr2:216808881(-) A-G exon 3'UTR    22484847 chr2:216808882(-) A-G exon 3'UTR    22484847 chr2:216808898(-) A-G exon 3'UTR    22484847 chr2:216808906(-) A-G exon 3'UTR    22484847 chr2:216808907(-) A-G exon 3'UTR    22484847 chr2:216808951(-) A-G exon 3'UTR    22484847 chr2:216808952(-) A-G exon 3'UTR    22484847 chr2:216808957(-) A-G exon 3'UTR    22484847 chr2:216808973(-) A-G exon 3'UTR    22484847 chr2:216808974(-) A-G exon 3'UTR    22484847 chr2:216808982(-) A-G exon 3'UTR    22484847 chr2:216809000(-) G-T exon 3'UTR    22484847 chr2:216821462(-) A-G intron -    22484847 chr2:216824712(-) A-G intron -    22484847 chr2:216824776(-) A-G intron -    22484847 chr2:216824782(-) A-G intron -    22484847 chr2:216824807(-) A-G intron -    22484847 chr2:216824883(-) A-G intron -    22484847 chr2:216824884(-) A-G intron -    22484847 chr2:216825296(-) A-G intron -    22484847 chr2:216825409(-) A-G intron -    22484847 chr2:216825435(-) A-G intron -    22484847 chr2:216825445(-) A-G intron -    22484847 chr2:216825470(-) A-G intron -    22484847 chr2:216825475(-) A-G intron -    22484847 chr2:216825505(-) A-G intron -    22484847 chr2:216826422(-) A-G intron -    22484847 chr2:216827667(-) A-G intron -    22484847 chr2:216827674(-) A-G intron -    22484847 chr2:216828174(-) T-A intron -    22484847 chr2:216829209(-) T-C intron -    22484847 chr2:216833681(-) A-G intron -    22484847 chr2:216837280(-) C-T intron -    22484847 chr2:216852098(-) A-G intron -    22484847 chr2:216852114(-) A-G intron -    22484847 chr2:216852173(-) A-G intron -    22484847 chr2:216852259(-) A-G intron -    22484847 chr2:216852362(-) T-C intron -    22484847 chr2:216852504(-) A-G intron -    22484847 chr2:216852510(-) A-G intron -    22484847 chr2:216852514(-) A-G intron -    22484847 chr2:216852543(-) A-G intron -    22484847 chr2:216852544(-) A-G intron -    22484847 chr2:216852574(-) A-G intron -    22484847 chr2:216852587(-) A-G intron -    22484847 chr2:216869253(-) A-G intron -    22484847 chr2:216870272(-) A-G intron -    22484847 chr2:216870280(-) A-G intron -    22484847 chr2:216874511(-) C-T intron -    22484847 chr2:216875099(-) C-A intron -    22484847 chr2:216875737(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MREG	chr2:216809226-216809227(-) m6A 3'UTR       24981863//22608085 chr2:216809244-216809245(-) m6A 3'UTR       24981863//22608085 chr2:216809429-216809430(-) m6A 3'UTR       24981863//27773535//22608085 chr2:216809521-216809522(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27773535//22608085 chr2:216809544-216809545(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27773535//22608085 chr2:216809615-216809616(-) m6A CDS       25456834//24981863//28052920//27773535//22608085 chr2:216809665-216809666(-) m6A CDS       25456834//24981863//22608085 chr2:216878257-216878258(-) m6A 5'UTR//intron       25456834//24981863 chr2:216878270-216878271(-) m6A 5'UTR//intron       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MREG	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART10-3p
Interactor2: MREG

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	cRep//miRanda//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).