Detail Information

Basic Information:


  VIRBase ID:  

VHID00332375

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:           GEMIN4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART10-3p GEMIN4
miRBase
Accession/Entrez ID		 MIMAT0003420 50628
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - HC56//HCAP1//HHRF-1//NEDMCR//p97

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GEMIN4
chr17:653433(-) A-I      intronic
chr17:653361(-) A-I      intronic
chr17:653407(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GEMIN4
chr17:653361(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GEMIN4
chr17:647702-647703(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647744-647745(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647760-647761(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647889-647890(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr17:647958-647959(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr17:647976-647977(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr17:647991-647992(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:648134-648135(-) m6A CDS       24284625//24209618//24981863//26404942//27371828//27773536//22575960//22608085
chr17:648230-648231(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648242-648243(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648260-648261(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648373-648374(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr17:648384-648385(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr17:648427-648428(-) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr17:648459-648460(-) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr17:648472-648473(-) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr17:648530-648531(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:648648-648649(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr17:648741-648742(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr17:648878-648879(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:648977-648978(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:648982-648983(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:648990-648991(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649046-649047(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649165-649166(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649211-649212(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649253-649254(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649279-649280(-) m6A CDS       24284625//24981863//22608085
chr17:649374-649375(-) m6A CDS       24284625//22608085
chr17:649396-649397(-) m6A CDS       24284625
chr17:649665-649666(-) m6A CDS       24284625//22575960
chr17:649708-649709(-) m6A CDS       24284625//22575960
chr17:649816-649817(-) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085
chr17:649904-649905(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649927-649928(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649994-649995(-) m1A 3'UTR//CDS       26863410//26863196
chr17:650035-650036(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650095-650096(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650128-650129(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650167-650168(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650191-650192(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650261-650262(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650348-650349(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650361-650362(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650446-650447(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650452-650453(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650482-650483(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650665-650666(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:650755-650756(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:650844-650845(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650862-650863(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650913-650914(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650998-650999(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:651014-651015(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:651262-651263(-) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085
chr17:651270-651271(-) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085
chr17:651313-651314(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085
chr17:651350-651351(-) m6A 5'UTR//intron       24284625//25456834//24981863
chr17:651366-651367(-) m6A 5'UTR//intron       24284625//24981863
chr17:651791-651792(-) m6A 5'UTR//intron       24284625
chr17:655265-655266(-) m6A 5'UTR//intron       24284625//24981863
chr17:655377-655378(-) m6A 5'UTR//CDS//intron       24284625//24981863
chr17:655859-655860(-) m6A 5'UTR//intron       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate GEMIN4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART10-3p
Interactor2: GEMIN4

Evidence Support:


Weak-Evidence HITS-CLIP
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22473208 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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