Basic Information:

  VIRBase ID:  

VHID00332130

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:  MIMAT0003420          FAM120A:  NM_001286722     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART10-3p	FAM120A
miRBase Accession/Entrez ID	MIMAT0003420	23196
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C9orf10//HBVPTPAP//OSSA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM120A	chr9:96234383(+) A-I      intronic chr9:96234438(+) A-I      intronic chr9:96310594(+) A-I      intronic chr9:96322470(+) A-I      intronic chr9:96311245(+) A-I      intronic chr9:96311205(+) A-I      intronic chr9:96247604(+) A-I      intronic chr9:96248335(+) A-I      intronic chr9:96235802(+) A-I      intronic chr9:96235496(+) A-I      intronic chr9:96235364(+) A-I      intronic chr9:96234386(+) A-I      intronic chr9:96234388(+) A-I      intronic chr9:96311204(+) A-I      intronic chr9:96248342(+) A-I      intronic chr9:96248388(+) A-I      intronic chr9:96248545(+) A-I      intronic chr9:96310512(+) A-I      intronic chr9:96236611(+) A-I      intronic chr9:96310574(+) A-I      intronic chr9:96235392(+) A-I      intronic chr9:96234343(+) A-I      intronic chr9:96234389(+) A-I      intronic chr9:96234422(+) A-I      intronic chr9:96234450(+) A-I      intronic chr9:96234502(+) A-I      intronic chr9:96235380(+) A-I      intronic chr9:96235417(+) A-I      intronic chr9:96235706(+) A-I      intronic chr9:96234395(+) A-I      intronic chr9:96235410(+) A-I      intronic chr9:96234451(+) A-I      intronic chr9:96247782(+) A-I      intronic chr9:96247765(+) A-I      intronic chr9:96247653(+) A-I      intronic chr9:96247622(+) A-I      intronic chr9:96234550(+) A-I      intronic chr9:96323789(+) A-I      intronic chr9:96246477(+) A-I      intronic chr9:96235471(+) A-I      intronic chr9:96235482(+) A-I      intronic chr9:96247090(+) A-I      intronic chr9:96311143(+) A-I      intronic chr9:96237060(+) A-I      intronic chr9:96235662(+) A-I      intronic chr9:96235837(+) A-I      intronic chr9:96310413(+) A-I      intronic chr9:96323725(+) A-I      intronic chr9:96282495(+) A-I      intronic chr9:96247077(+) A-I      intronic chr9:96234286(+) A-I      intronic chr9:96316970(+) A-I      intronic chr9:96322456(+) A-I      intronic chr9:96322391(+) A-I      intronic chr9:96311139(+) A-I      intronic chr9:96311138(+) A-I      intronic chr9:96234287(+) A-I      intronic chr9:96235319(+) A-I      intronic chr9:96310468(+) A-I      intronic chr9:96310443(+) A-I      intronic chr9:96235846(+) A-I      intronic chr9:96310603(+) A-I      intronic chr9:96282374(+) A-I      intronic chr9:96235353(+) A-I      intronic chr9:96247867(+) A-I      intronic chr9:96235727(+) A-I      intronic chr9:96234492(+) A-I      intronic chr9:96235358(+) A-I      intronic chr9:96235399(+) A-I      intronic chr9:96235374(+) A-I      intronic chr9:96323938(+) A-I      intronic chr9:96235652(+) A-I      intronic chr9:96311307(+) A-I      intronic chr9:96310644(+) A-I      intronic chr9:96247758(+) A-I      intronic chr9:96247036(+) A-I      intronic chr9:96246436(+) A-I      intronic chr9:96247696(+) A-I      intronic chr9:96323916(+) A-I      intronic chr9:96234419(+) A-I      intronic chr9:96235400(+) A-I      intronic chr9:96235528(+) A-I      intronic chr9:96282392(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM120A	chr9:96325167(+) A-I intron -    15342557 chr9:96325181(+) A-I intron -    15342557 chr9:96325209(+) A-I intron -    15342557 chr9:96325223(+) A-I intron -    15342557 chr9:96325237(+) A-I intron -    15342557 chr9:96326423(+) A-I intron -    15342557 chr9:96326736(+) A-I exon CDS    15342557 chr9:96235358(+) A-G intron -    22484847 chr9:96235644(+) G-C intron -    22484847 chr9:96235837(+) A-G intron -    22484847 chr9:96241639(+) C-G intron -    22484847 chr9:96310525(+) A-G intron -    22484847 chr9:96316796(+) A-G intron -    22484847 chr9:96323789(+) A-G intron -    22484847 chr9:96323816(+) A-G intron -    22484847 chr9:96323938(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM120A	chr9:96214015-96214016(+) m6A 5'UTR       24209618//24981863 chr9:96214219-96214220(+) m6A CDS       24209618//25456834//24981863 chr9:96214320-96214321(+) m6A CDS       24981863//22575960 chr9:96214411-96214412(+) m6A CDS       22575960 chr9:96214579-96214580(+) m6A CDS       25456834//27371828//27773536//22575960//22608085 chr9:96233559-96233560(+) m6A CDS       24981863//26404942//22575960 chr9:96233627-96233628(+) m6A CDS       22575960 chr9:96259831-96259832(+) m6A CDS       - chr9:96261077-96261078(+) m6A CDS       - chr9:96277955-96277956(+) m6A CDS       - chr9:96278349-96278350(+) m6A CDS       24284625 chr9:96278379-96278380(+) m6A CDS       24284625 chr9:96285587-96285588(+) m6A intron       24284625//22575960 chr9:96289450-96289451(+) m6A CDS       22575960 chr9:96289504-96289505(+) m6A CDS       22575960 chr9:96289513-96289514(+) m6A CDS       22575960 chr9:96289518-96289519(+) m6A CDS       22575960 chr9:96291743-96291744(+) m6A CDS       22575960 chr9:96291752-96291753(+) m6A CDS//exon       22575960 chr9:96294568-96294569(+) m6A CDS//exon       24981863 chr9:96294576-96294577(+) m6A CDS//exon       24981863 chr9:96294593-96294594(+) m6A CDS//exon       24981863 chr9:96294794-96294795(+) m6A 3'UTR//exon//intron       24981863 chr9:96305595-96305596(+) m6A CDS       22575960 chr9:96305641-96305642(+) m6A CDS       22575960 chr9:96305647-96305648(+) m6A CDS       22575960 chr9:96305678-96305679(+) Gm CDS       - chr9:96305686-96305687(+) m6A CDS       22575960 chr9:96318843-96318844(+) m6A CDS       - chr9:96320944-96320945(+) m6A CDS//intron       22575960 chr9:96320981-96320982(+) m6A CDS//intron       - chr9:96323421-96323422(+) m6A CDS       - chr9:96323520-96323521(+) m6A CDS       - chr9:96324526-96324527(+) m6A CDS       - chr9:96324569-96324570(+) m6A CDS       - chr9:96326515-96326516(+) m6A CDS       - chr9:96326554-96326555(+) m6A CDS       - chr9:96326763-96326764(+) m6A CDS       24284625//24981863//26404942//22608085 chr9:96326822-96326823(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr9:96326938-96326939(+) m6A 3'UTR       24981863//27773535//22608085 chr9:96326979-96326980(+) m6A 3'UTR       24981863//27773535 chr9:96327028-96327029(+) m6A 3'UTR       24981863//27773535 chr9:96327097-96327098(+) m6A 3'UTR       24981863 chr9:96327134-96327135(+) m6A 3'UTR       24981863 chr9:96327146-96327147(+) m6A 3'UTR       24981863 chr9:96327604-96327605(+) Y 3'UTR       25219674 chr9:96328285-96328286(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM120A	Chromatin K562 cells     - Cytoplasm HepG2 cells     32755630 Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HepG2 cells     32755630 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART10-3p
Interactor2: FAM120A

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).