Detail Information

Basic Information:


  VIRBase ID:  

VHID00331220

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART10-3p:           NOTCH1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART10-3p NOTCH1
miRBase
Accession/Entrez ID		 MIMAT0003420 4851
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - AOS5//AOVD1//hN1//TAN1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NOTCH1
chr9:139418701(-) A-I      intronic
chr9:139418736(-) A-I      intronic
chr9:139418676(-) A-I      intronic
chr9:139418671(-) A-I      intronic
chr9:139398768(-) A-I      intronic
chr9:139432082(-) A-I      intronic
chr9:139418711(-) A-I      intronic
chr9:139418750(-) A-I      intronic
chr9:139419218(-) A-I      intronic
chr9:139432165(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NOTCH1
chr9:139389468-139389469(-) m6A 3'UTR       25456834//27371828
chr9:139389504-139389505(-) m6A 3'UTR       24284625//25456834//27371828//27773536
chr9:139389614-139389615(-) m6A 3'UTR       24284625//25456834//24981863//27371828
chr9:139389670-139389671(-) m6A 3'UTR       24284625//25456834//24981863//27371828
chr9:139389685-139389686(-) m6A 3'UTR       24284625//25456834//24981863//27371828
chr9:139390202-139390203(-) m6A 3'UTR       24981863//27773535
chr9:139390273-139390274(-) m6A 3'UTR       24981863//27773535
chr9:139390294-139390295(-) m6A 3'UTR       24284625//24981863//27773535
chr9:139390343-139390344(-) m6A 3'UTR       24284625//24981863//27773535
chr9:139390423-139390424(-) m6A 3'UTR       24284625//24981863//27773535
chr9:139390504-139390505(-) m6A 3'UTR       24284625//24981863
chr9:139390706-139390707(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960
chr9:139390988-139390989(-) m6A CDS       24284625//24209618//25456834//24981863//27371828
chr9:139391003-139391004(-) m6A CDS       24284625//24209618//25456834//24981863//27371828
chr9:139391024-139391025(-) m6A CDS       24284625//24209618//25456834//24981863//27371828
chr9:139391046-139391047(-) m6A CDS       24284625//24209618//25456834//24981863//27371828
chr9:139391228-139391229(-) m6A CDS       24284625//25456834//24981863//27371828
chr9:139391388-139391389(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr9:139391588-139391589(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr9:139391615-139391616(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr9:139391666-139391667(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr9:139391909-139391910(-) m6A CDS       24284625//24981863//27371828//22575960
chr9:139391927-139391928(-) m6A CDS       24284625//24981863//27371828//22575960
chr9:139391945-139391946(-) m6A CDS       24284625//24981863//27371828//22575960
chr9:139391964-139391965(-) m6A CDS       24284625//22575960
chr9:139392003-139392004(-) m6A CDS       24284625//22575960
chr9:139393357-139393358(-) m6A CDS       24284625//22575960
chr9:139393414-139393415(-) m6A CDS       24284625
chr9:139393607-139393608(-) m6A CDS       24284625
chr9:139393685-139393686(-) m6A CDS       24284625
chr9:139393697-139393698(-) m6A CDS       24284625
chr9:139395064-139395065(-) m6A CDS       24284625
chr9:139395149-139395150(-) m6A CDS       -
chr9:139395167-139395168(-) m6A CDS       -
chr9:139396307-139396308(-) m6A CDS       27371828
chr9:139396325-139396326(-) m6A CDS       27371828
chr9:139396466-139396467(-) m6A CDS       27371828
chr9:139396474-139396475(-) m6A CDS       27371828
chr9:139399142-139399143(-) m6A CDS//exon       -
chr9:139399463-139399464(-) m6A CDS       24284625//25456834//24981863//27371828
chr9:139399529-139399530(-) m6A CDS       24284625//25456834//27371828
chr9:139399881-139399882(-) m6A CDS       27371828
chr9:139400061-139400062(-) m6A CDS       24284625//27371828
chr9:139400143-139400144(-) m6A CDS       24284625//22575960
chr9:139404319-139404320(-) m6A CDS       27371828
chr9:139405128-139405129(-) m6A CDS       27371828
chr9:139405187-139405188(-) m6A CDS       27371828
chr9:139405251-139405252(-) m6A CDS       27371828
chr9:139405644-139405645(-) m6A CDS       27371828
chr9:139407887-139407888(-) m6A CDS       27371828
chr9:139407954-139407955(-) m6A CDS       27371828
chr9:139409783-139409784(-) Am CDS       -
chr9:139409785-139409786(-) m6A CDS       -
chr9:139409940-139409941(-) m6A CDS       -
chr9:139409978-139409979(-) m6A CDS       24284625
chr9:139410033-139410034(-) m6A CDS       24284625
chr9:139410140-139410141(-) m6A CDS       -
chr9:139413968-139413969(-) m6A CDS       -
chr9:139414001-139414002(-) m6A CDS       -
chr9:139417158-139417159(-) m6A exon//intron       -
chr9:139418263-139418264(-) m6A CDS//exon       24284625
chr9:139418320-139418321(-) m6A CDS//exon       24284625
chr9:139418338-139418339(-) m6A CDS//exon       24284625
chr9:139418354-139418355(-) m6A CDS       24284625
chr9:139418395-139418396(-) m6A CDS       24284625
chr9:139438527-139438528(-) m6A CDS       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate NOTCH1
Chromatin K562 cells     -
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART10-3p
Interactor2: NOTCH1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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