Basic Information:

  VIRBase ID:  

VHID00329038

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-3p:  MIMAT0003419          SLC35F6:  NM_017877     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-3p	SLC35F6
miRBase Accession/Entrez ID	MIMAT0003419	54978
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ANT2BP//C2orf18//TANGO9

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC35F6	chr2:27001935(+) A-I      3'UTR chr2:27001980(+) A-I      3'UTR chr2:27002058(+) A-I      3'UTR chr2:27002087(+) A-I      3'UTR chr2:27002471(+) A-I      3'UTR chr2:27002525(+) A-I      3'UTR chr2:27002790(+) A-I      3'UTR chr2:27002815(+) A-I      3'UTR chr2:27002823(+) A-I      3'UTR chr2:27002872(+) A-I      3'UTR chr2:27002897(+) A-I      3'UTR chr2:27002909(+) A-I      3'UTR chr2:27002914(+) A-I      3'UTR chr2:27002935(+) A-I      3'UTR chr2:27002936(+) A-I      3'UTR chr2:27001902(+) A-I      3'UTR chr2:27001948(+) A-I      3'UTR chr2:27001908(+) A-I      3'UTR chr2:27001909(+) A-I      3'UTR chr2:27001913(+) A-I      3'UTR chr2:26996741(+) A-I      intronic chr2:26996291(+) A-I      intronic chr2:26996152(+) A-I      intronic chr2:26991650(+) A-I      intronic chr2:26991423(+) A-I      intronic chr2:26991636(+) A-I      intronic chr2:26991711(+) A-I      intronic chr2:26991543(+) A-I      intronic chr2:27002910(+) A-I      3'UTR chr2:27001997(+) A-I      3'UTR chr2:27002017(+) A-I      3'UTR chr2:27002861(+) A-I      3'UTR chr2:27002949(+) A-I      3'UTR chr2:27002059(+) A-I      3'UTR chr2:27002937(+) A-I      3'UTR chr2:27002071(+) A-I      3'UTR chr2:27002073(+) A-I      3'UTR chr2:27002776(+) A-I      3'UTR chr2:27002802(+) A-I      3'UTR chr2:27001827(+) A-I      3'UTR chr2:27002967(+) A-I      3'UTR chr2:27001829(+) A-I      3'UTR chr2:27001926(+) A-I      3'UTR chr2:27002848(+) A-I      3'UTR chr2:27001938(+) A-I      3'UTR chr2:27001950(+) A-I      3'UTR chr2:26996707(+) A-I      intronic chr2:26993426(+) A-I      intronic chr2:26996681(+) A-I      intronic chr2:26996664(+) A-I      intronic chr2:26991581(+) A-I      intronic chr2:26996095(+) A-I      intronic chr2:27002513(+) A-I      3'UTR chr2:27001825(+) A-I      3'UTR chr2:27002716(+) A-I      3'UTR chr2:27001994(+) A-I      3'UTR chr2:27002523(+) A-I      3'UTR chr2:27002927(+) A-I      3'UTR chr2:27001886(+) A-I      3'UTR chr2:27002490(+) A-I      3'UTR chr2:27002807(+) A-I      3'UTR chr2:27002806(+) A-I      3'UTR chr2:26996119(+) A-I      intronic chr2:26991801(+) A-I      intronic chr2:26993093(+) A-I      intronic chr2:26993424(+) A-I      intronic chr2:26990623(+) A-I      intronic chr2:26996250(+) A-I      intronic chr2:26996581(+) A-I      intronic chr2:26991369(+) A-I      intronic chr2:26991637(+) A-I      intronic chr2:26991371(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC35F6	chr2:26987160-26987161(+) m6A 5'UTR//exon       24284625//24981863 chr2:26987199-26987200(+) m6A 5'UTR//exon       24284625//24981863 chr2:26987226-26987227(+) m6A CDS//exon       24284625//24981863 chr2:26997126-26997127(+) m6A CDS//intron       24284625//24981863 chr2:26997990-26997991(+) m6A CDS//intron       24284625 chr2:26998002-26998003(+) m6A 3'UTR//CDS//intron       24284625 chr2:26998064-26998065(+) m6A 3'UTR//CDS//intron       24284625 chr2:26998337-26998338(+) m6A 3'UTR//CDS//exon       24284625 chr2:27000984-27000985(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960//22608085 chr2:27000995-27000996(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960//22608085 chr2:27001120-27001121(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:27001149-27001150(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:27001336-27001337(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:27001427-27001428(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr2:27001499-27001500(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr2:27001611-27001612(+) m6A 3'UTR       24284625//24209618 chr2:27001626-27001627(+) m6A 3'UTR       24284625//24209618 chr2:27001703-27001704(+) m6A 3'UTR       - chr2:27003406-27003407(+) m6A 3'UTR       26404942 chr2:27003493-27003494(+) m6A 3'UTR       24284625//24981863 chr2:27003622-27003623(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:27003632-27003633(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:27003667-27003668(+) m6A 3'UTR       24284625//24981863 chr2:27003687-27003688(+) m6A 3'UTR       24284625 chr2:27003716-27003717(+) m6A 3'UTR       24284625 chr2:27003909-27003910(+) m6A 3'UTR       24981863//27773535//22608085 chr2:27003929-27003930(+) m6A 3'UTR       24981863//27773535//22608085 chr2:27003950-27003951(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC35F6	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-3p
Interactor2: SLC35F6

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.