Basic Information:

  VIRBase ID:  

VHID00328366

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8941

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-3p:  MIMAT0003419          MALT1:  NM_173844     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-3p	MALT1
miRBase Accession/Entrez ID	MIMAT0003419	10892
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD12//MLT//MLT1//PCASP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MALT1	chr18:56398323(+) A-I      intronic chr18:56398313(+) A-I      intronic chr18:56418390(+) A-I      3'UTR chr18:56419846(+) A-I      3'UTR chr18:56398310(+) A-I      intronic chr18:56403338(+) A-I      intronic chr18:56400236(+) A-I      intronic chr18:56394639(+) A-I      intronic chr18:56356223(+) A-I      intronic chr18:56356222(+) A-I      intronic chr18:56356208(+) A-I      intronic chr18:56356169(+) A-I      intronic chr18:56356206(+) A-I      intronic chr18:56356183(+) A-I      intronic chr18:56373623(+) A-I      intronic chr18:56419977(+) A-I      3'UTR chr18:56372556(+) A-I      intronic chr18:56386971(+) A-I      intronic chr18:56398365(+) A-I      intronic chr18:56398341(+) A-I      intronic chr18:56398372(+) A-I      intronic chr18:56398371(+) A-I      intronic chr18:56398368(+) A-I      intronic chr18:56370335(+) A-I      intronic chr18:56370341(+) A-I      intronic chr18:56368124(+) A-I      intronic chr18:56340780(+) A-I      intronic chr18:56360517(+) A-I      intronic chr18:56347994(+) A-I      intronic chr18:56347978(+) A-I      intronic chr18:56347971(+) A-I      intronic chr18:56347216(+) A-I      intronic chr18:56340873(+) A-I      intronic chr18:56347183(+) A-I      intronic chr18:56346909(+) A-I      intronic chr18:56346865(+) A-I      intronic chr18:56346805(+) A-I      intronic chr18:56405091(+) A-I      intronic chr18:56405058(+) A-I      intronic chr18:56405037(+) A-I      intronic chr18:56404908(+) A-I      intronic chr18:56404865(+) A-I      intronic chr18:56342718(+) A-I      intronic chr18:56342716(+) A-I      intronic chr18:56404505(+) A-I      intronic chr18:56404504(+) A-I      intronic chr18:56404479(+) A-I      intronic chr18:56400309(+) A-I      intronic chr18:56400308(+) A-I      intronic chr18:56394827(+) A-I      intronic chr18:56393288(+) A-I      intronic chr18:56392529(+) A-I      intronic chr18:56371882(+) A-I      intronic chr18:56371864(+) A-I      intronic chr18:56371815(+) A-I      intronic chr18:56342710(+) A-I      intronic chr18:56371806(+) A-I      intronic chr18:56371789(+) A-I      intronic chr18:56371788(+) A-I      intronic chr18:56371710(+) A-I      intronic chr18:56370538(+) A-I      intronic chr18:56370478(+) A-I      intronic chr18:56370427(+) A-I      intronic chr18:56368225(+) A-I      intronic chr18:56370411(+) A-I      intronic chr18:56404563(+) A-I      intronic chr18:56420032(+) A-I      3'UTR chr18:56420674(+) A-I      3'UTR chr18:56419893(+) A-I      3'UTR chr18:56418459(+) A-I      3'UTR chr18:56420014(+) A-I      3'UTR chr18:56418514(+) A-I      3'UTR chr18:56420673(+) A-I      3'UTR chr18:56419782(+) A-I      3'UTR chr18:56419801(+) A-I      3'UTR chr18:56418500(+) A-I      3'UTR chr18:56420625(+) A-I      3'UTR chr18:56420573(+) A-I      3'UTR chr18:56419815(+) A-I      3'UTR chr18:56419880(+) A-I      3'UTR chr18:56420562(+) A-I      3'UTR chr18:56419747(+) A-I      3'UTR chr18:56420033(+) A-I      3'UTR chr18:56346946(+) A-I      intronic chr18:56393146(+) A-I      intronic chr18:56342700(+) A-I      intronic chr18:56404564(+) A-I      intronic chr18:56369495(+) A-I      intronic chr18:56413293(+) A-I      intronic chr18:56405076(+) A-I      intronic chr18:56404670(+) A-I      intronic chr18:56356125(+) A-I      intronic chr18:56355691(+) A-I      intronic chr18:56393190(+) A-I      intronic chr18:56368098(+) A-I      intronic chr18:56356174(+) A-I      intronic chr18:56369359(+) A-I      intronic chr18:56404980(+) A-I      intronic chr18:56369382(+) A-I      intronic chr18:56370510(+) A-I      intronic chr18:56403329(+) A-I      intronic chr18:56351339(+) A-I      intronic chr18:56400323(+) A-I      intronic chr18:56369591(+) A-I      intronic chr18:56371825(+) A-I      intronic chr18:56346929(+) A-I      intronic chr18:56371828(+) A-I      intronic chr18:56404521(+) A-I      intronic chr18:56404944(+) A-I      intronic chr18:56404914(+) A-I      intronic chr18:56370413(+) A-I      intronic chr18:56404457(+) A-I      intronic chr18:56400243(+) A-I      intronic chr18:56371782(+) A-I      intronic chr18:56405089(+) A-I      intronic chr18:56373347(+) A-I      intronic chr18:56370468(+) A-I      intronic chr18:56371873(+) A-I      intronic chr18:56404367(+) A-I      intronic chr18:56351348(+) A-I      intronic chr18:56404876(+) A-I      intronic chr18:56420591(+) A-I      3'UTR chr18:56369536(+) A-I      intronic chr18:56420660(+) A-I      3'UTR chr18:56419797(+) A-I      3'UTR chr18:56418542(+) A-I      3'UTR chr18:56419934(+) A-I      3'UTR chr18:56403242(+) A-I      intronic chr18:56418566(+) A-I      3'UTR chr18:56419764(+) A-I      3'UTR chr18:56419755(+) A-I      3'UTR chr18:56420470(+) A-I      3'UTR chr18:56418643(+) A-I      3'UTR chr18:56420020(+) A-I      3'UTR chr18:56405050(+) A-I      intronic chr18:56369509(+) A-I      intronic chr18:56420701(+) A-I      3'UTR chr18:56419756(+) A-I      3'UTR chr18:56420636(+) A-I      3'UTR chr18:56418415(+) A-I      3'UTR chr18:56419825(+) A-I      3'UTR chr18:56419452(+) A-I      3'UTR chr18:56420715(+) A-I      3'UTR chr18:56419788(+) A-I      3'UTR chr18:56405004(+) A-I      intronic chr18:56419911(+) A-I      3'UTR chr18:56420488(+) A-I      3'UTR chr18:56420713(+) A-I      3'UTR chr18:56403257(+) A-I      intronic chr18:56419885(+) A-I      3'UTR chr18:56418570(+) A-I      3'UTR chr18:56418464(+) A-I      3'UTR chr18:56420565(+) A-I      3'UTR chr18:56368277(+) A-I      intronic chr18:56371750(+) A-I      intronic chr18:56420619(+) A-I      3'UTR chr18:56404956(+) A-I      intronic chr18:56404612(+) A-I      intronic chr18:56419869(+) A-I      3'UTR chr18:56420567(+) A-I      3'UTR chr18:56420505(+) A-I      3'UTR chr18:56418493(+) A-I      3'UTR chr18:56419761(+) A-I      3'UTR chr18:56420555(+) A-I      3'UTR chr18:56371956(+) A-I      intronic chr18:56420526(+) A-I      3'UTR chr18:56418583(+) A-I      3'UTR chr18:56404954(+) A-I      intronic chr18:56419928(+) A-I      3'UTR chr18:56420553(+) A-I      3'UTR chr18:56419971(+) A-I      3'UTR chr18:56420525(+) A-I      3'UTR chr18:56420458(+) A-I      3'UTR chr18:56420506(+) A-I      3'UTR chr18:56420659(+) A-I      3'UTR chr18:56418445(+) A-I      3'UTR chr18:56418561(+) A-I      3'UTR chr18:56400269(+) A-I      intronic chr18:56419783(+) A-I      3'UTR chr18:56418424(+) A-I      3'UTR chr18:56420606(+) A-I      3'UTR chr18:56420700(+) A-I      3'UTR chr18:56418642(+) A-I      3'UTR chr18:56419465(+) A-I      3'UTR chr18:56418450(+) A-I      3'UTR chr18:56377778(+) A-I      intronic chr18:56420019(+) A-I      3'UTR chr18:56370329(+) A-I      intronic chr18:56418449(+) A-I      3'UTR chr18:56369426(+) A-I      intronic chr18:56419992(+) A-I      3'UTR chr18:56368164(+) A-I      intronic chr18:56419935(+) A-I      3'UTR chr18:56418517(+) A-I      3'UTR chr18:56419834(+) A-I      3'UTR chr18:56419886(+) A-I      3'UTR chr18:56419451(+) A-I      3'UTR chr18:56420616(+) A-I      3'UTR chr18:56356237(+) A-I      intronic chr18:56373237(+) A-I      intronic chr18:56420624(+) A-I      3'UTR chr18:56403300(+) A-I      intronic chr18:56371819(+) A-I      intronic chr18:56347234(+) A-I      intronic chr18:56404371(+) A-I      intronic chr18:56400196(+) A-I      intronic chr18:56400343(+) A-I      intronic chr18:56405024(+) A-I      intronic chr18:56353542(+) A-I      intronic chr18:56370438(+) A-I      intronic chr18:56371818(+) A-I      intronic chr18:56404941(+) A-I      intronic chr18:56404571(+) A-I      intronic chr18:56404555(+) A-I      intronic chr18:56355664(+) A-I      intronic chr18:56369535(+) A-I      intronic chr18:56400260(+) A-I      intronic chr18:56371854(+) A-I      intronic chr18:56400229(+) A-I      intronic chr18:56370495(+) A-I      intronic chr18:56393128(+) A-I      intronic chr18:56370514(+) A-I      intronic chr18:56404317(+) A-I      intronic chr18:56371720(+) A-I      intronic chr18:56371938(+) A-I      intronic chr18:56368117(+) A-I      intronic chr18:56368039(+) A-I      intronic chr18:56394782(+) A-I      intronic chr18:56396546(+) A-I      intronic chr18:56404526(+) A-I      intronic chr18:56370332(+) A-I      intronic chr18:56368123(+) A-I      intronic chr18:56405015(+) A-I      intronic chr18:56369603(+) A-I      intronic chr18:56404683(+) A-I      intronic chr18:56404863(+) A-I      intronic chr18:56404587(+) A-I      intronic chr18:56405049(+) A-I      intronic chr18:56368211(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MALT1	chr18:56370329(+) A-I intron -    22327324 chr18:56386252(+) A-I intron -    22327324 chr18:56404434(+) A-I intron -    22327324 chr18:56404571(+) A-I intron -    22327324 chr18:56386252(+) A-G intron -    22484847 chr18:56369328(+) A-G intron -    22484847 chr18:56369335(+) A-G intron -    22484847 chr18:56369495(+) A-G intron -    22484847 chr18:56369536(+) A-G intron -    22484847 chr18:56370329(+) A-G intron -    22484847 chr18:56370438(+) A-G intron -    22484847 chr18:56370469(+) A-G intron -    22484847 chr18:56370503(+) C-T intron -    22484847 chr18:56371750(+) A-G intron -    22484847 chr18:56371801(+) A-G intron -    22484847 chr18:56403300(+) A-G intron -    22484847 chr18:56403304(+) A-G intron -    22484847 chr18:56403318(+) A-G intron -    22484847 chr18:56404434(+) A-G intron -    22484847 chr18:56404457(+) A-G intron -    22484847 chr18:56404571(+) A-G intron -    22484847 chr18:56404587(+) A-G intron -    22484847 chr18:56404670(+) A-G intron -    22484847 chr18:56404863(+) A-G intron -    22484847 chr18:56404876(+) A-G intron -    22484847 chr18:56404914(+) A-G intron -    22484847 chr18:56405004(+) A-G intron -    22484847 chr18:56405024(+) A-G intron -    22484847 chr18:56405049(+) A-G intron -    22484847 chr18:56405077(+) A-G intron -    22484847 chr18:56386976(+) A-G intron -    22484847 chr18:56386985(+) A-G intron -    22484847 chr18:56387006(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MALT1	chr18:56338698-56338699(+) m6A 5'UTR       24981863 chr18:56338891-56338892(+) m6A CDS       24209618 chr18:56400765-56400766(+) m6A CDS//exon       22575960 chr18:56400770-56400771(+) m6A CDS//exon       22575960 chr18:56414638-56414639(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr18:56414700-56414701(+) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr18:56414725-56414726(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:56414745-56414746(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414771-56414772(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414783-56414784(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414862-56414863(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr18:56414942-56414943(+) m6A CDS//exon       24284625//24981863//26404942//22575960//22608085 chr18:56415017-56415018(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr18:56415144-56415145(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr18:56415206-56415207(+) m6A 3'UTR//exon       24981863//22608085 chr18:56415214-56415215(+) m6A 3'UTR//exon       24981863//22608085 chr18:56415250-56415251(+) m6A 3'UTR//exon       24981863//22608085 chr18:56416178-56416179(+) m6A 3'UTR       24981863 chr18:56416183-56416184(+) m6A 3'UTR       24981863 chr18:56416196-56416197(+) m6A 3'UTR       24981863 chr18:56416226-56416227(+) m6A 3'UTR       24981863 chr18:56417096-56417097(+) m6A 3'UTR       24981863 chr18:56417137-56417138(+) m6A 3'UTR       24981863 chr18:56417286-56417287(+) m6A 3'UTR       27773535 chr18:56417630-56417631(+) m6A 3'UTR       - chr18:56417660-56417661(+) m6A 3'UTR       - chr18:56417678-56417679(+) m6A 3'UTR       - chr18:56417691-56417692(+) m6A 3'UTR       - chr18:56417743-56417744(+) m6A 3'UTR       - chr18:56417764-56417765(+) m6A 3'UTR       - chr18:56417786-56417787(+) m6A 3'UTR       - chr18:56417791-56417792(+) m6A 3'UTR       - chr18:56417805-56417806(+) m6A 3'UTR       - chr18:56417894-56417895(+) m6A 3'UTR       - chr18:56417978-56417979(+) m6A 3'UTR       - chr18:56417998-56417999(+) m6A 3'UTR       - chr18:56418012-56418013(+) m6A 3'UTR       - chr18:56418058-56418059(+) m6A 3'UTR       - chr18:56418091-56418092(+) m6A 3'UTR       - chr18:56418107-56418108(+) m6A 3'UTR       - chr18:56418140-56418141(+) m6A 3'UTR       - chr18:56418214-56418215(+) m6A 3'UTR       - chr18:56418222-56418223(+) m6A 3'UTR       - chr18:56418271-56418272(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MALT1	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-3p
Interactor2: MALT1

Evidence Support:

Strong-Evidence	3'UTR indicator assay
Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

[1]PMID	30615681	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	293T cells	Interactor2 expression	None
Description	Luciferase knockdown was observed for 12 out of 15 PAR-CLIP-identified miRNA interactions, confirming these cellular 3'UTRs as targets of the EBV miRNAs (Fig 3A-3C).

[2]PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.