Basic Information:

  VIRBase ID:  

VHID00326671

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART8-3p:  MIMAT0003418          FAM177A1:  NM_001079519     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART8-3p	FAM177A1
miRBase Accession/Entrez ID	MIMAT0003418	283635
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf24

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM177A1	chr14:35532568(+) A-I      intronic chr14:35518263(+) A-I      intronic chr14:35518249(+) A-I      intronic chr14:35518244(+) A-I      intronic chr14:35532571(+) A-I      intronic chr14:35519492(+) A-I      intronic chr14:35518923(+) A-I      intronic chr14:35518306(+) A-I      intronic chr14:35519467(+) A-I      intronic chr14:35519495(+) A-I      intronic chr14:35519489(+) A-I      intronic chr14:35532602(+) A-I      intronic chr14:35532633(+) A-I      intronic chr14:35535328(+) A-I      intronic chr14:35535710(+) A-I      intronic chr14:35535714(+) A-I      intronic chr14:35539635(+) A-I      intronic chr14:35536139(+) A-I      intronic chr14:35519330(+) A-I      intronic chr14:35536212(+) A-I      intronic chr14:35538548(+) A-I      intronic chr14:35538609(+) A-I      intronic chr14:35538665(+) A-I      intronic chr14:35518978(+) A-I      intronic chr14:35539653(+) A-I      intronic chr14:35518979(+) A-I      intronic chr14:35520893(+) A-I      intronic chr14:35522021(+) A-I      intronic chr14:35528271(+) A-I      intronic chr14:35540410(+) A-I      intronic chr14:35539490(+) A-I      intronic chr14:35532704(+) A-I      intronic chr14:35528353(+) A-I      intronic chr14:35519398(+) A-I      intronic chr14:35518200(+) A-I      intronic chr14:35518262(+) A-I      intronic chr14:35518294(+) A-I      intronic chr14:35518750(+) A-I      intronic chr14:35519424(+) A-I      intronic chr14:35518780(+) A-I      intronic chr14:35518826(+) A-I      intronic chr14:35518897(+) A-I      intronic chr14:35518903(+) A-I      intronic chr14:35521689(+) A-I      intronic chr14:35521949(+) A-I      intronic chr14:35543468(+) A-I      intronic chr14:35518814(+) A-I      intronic chr14:35527900(+) A-I      intronic chr14:35518948(+) A-I      intronic chr14:35528091(+) A-I      intronic chr14:35518726(+) A-I      intronic chr14:35539510(+) A-I      intronic chr14:35524787(+) A-I      intronic chr14:35518277(+) A-I      intronic chr14:35527438(+) A-I      intronic chr14:35522037(+) A-I      intronic chr14:35527349(+) A-I      intronic chr14:35544175(+) A-I      intronic chr14:35528009(+) A-I      intronic chr14:35521859(+) A-I      intronic chr14:35524898(+) A-I      intronic chr14:35516844(+) A-I      intronic chr14:35524795(+) A-I      intronic chr14:35524766(+) A-I      intronic chr14:35519342(+) A-I      intronic chr14:35524826(+) A-I      intronic chr14:35524062(+) A-I      intronic chr14:35528039(+) A-I      intronic chr14:35521884(+) A-I      intronic chr14:35524063(+) A-I      intronic chr14:35521899(+) A-I      intronic chr14:35516808(+) A-I      intronic chr14:35521977(+) A-I      intronic chr14:35533179(+) A-I      intronic chr14:35544188(+) A-I      intronic chr14:35522936(+) A-I      intronic chr14:35528259(+) A-I      intronic chr14:35533505(+) A-I      intronic chr14:35532592(+) A-I      intronic chr14:35524378(+) A-I      intronic chr14:35538657(+) A-I      intronic chr14:35544151(+) A-I      intronic chr14:35528028(+) A-I      intronic chr14:35518359(+) A-I      intronic chr14:35523039(+) A-I      intronic chr14:35518971(+) A-I      intronic chr14:35538658(+) A-I      intronic chr14:35516793(+) A-I      intronic chr14:35544164(+) A-I      intronic chr14:35524765(+) A-I      intronic chr14:35533186(+) A-I      intronic chr14:35543649(+) A-I      intronic chr14:35516779(+) A-I      intronic chr14:35524744(+) A-I      intronic chr14:35528222(+) A-I      intronic chr14:35539745(+) A-I      intronic chr14:35527826(+) A-I      intronic chr14:35539207(+) A-I      intronic chr14:35524714(+) A-I      intronic chr14:35519245(+) A-I      intronic chr14:35541387(+) A-I      intronic chr14:35520467(+) A-I      intronic chr14:35524250(+) A-I      intronic chr14:35528281(+) A-I      intronic chr14:35539639(+) A-I      intronic chr14:35523149(+) A-I      intronic chr14:35524703(+) A-I      intronic chr14:35528206(+) A-I      intronic chr14:35533927(+) A-I      intronic chr14:35528087(+) A-I      intronic chr14:35539242(+) A-I      intronic chr14:35519237(+) A-I      intronic chr14:35543625(+) A-I      intronic chr14:35528203(+) A-I      intronic chr14:35539795(+) A-I      intronic chr14:35543993(+) A-I      intronic chr14:35523919(+) A-I      intronic chr14:35533937(+) A-I      intronic chr14:35539616(+) A-I      intronic chr14:35539046(+) A-I      intronic chr14:35519358(+) A-I      intronic chr14:35533958(+) A-I      intronic chr14:35539223(+) A-I      intronic chr14:35534034(+) A-I      intronic chr14:35534040(+) A-I      intronic chr14:35534049(+) A-I      intronic chr14:35534065(+) A-I      intronic chr14:35521975(+) A-I      intronic chr14:35518158(+) A-I      intronic chr14:35528197(+) A-I      intronic chr14:35535037(+) A-I      intronic chr14:35524389(+) A-I      intronic chr14:35535043(+) A-I      intronic chr14:35544149(+) A-I      intronic chr14:35523925(+) A-I      intronic chr14:35535064(+) A-I      intronic chr14:35535316(+) A-I      intronic chr14:35528307(+) A-I      intronic chr14:35539640(+) A-I      intronic chr14:35523148(+) A-I      intronic chr14:35551534(+) A-I      3'UTR chr14:35551676(+) A-I      3'UTR chr14:35551640(+) A-I      3'UTR chr14:35551679(+) A-I      3'UTR chr14:35551669(+) A-I      3'UTR chr14:35551660(+) A-I      3'UTR chr14:35551634(+) A-I      3'UTR chr14:35551598(+) A-I      3'UTR chr14:35551568(+) A-I      3'UTR chr14:35551563(+) A-I      3'UTR chr14:35551555(+) A-I      3'UTR chr14:35551538(+) A-I      3'UTR chr14:35551533(+) A-I      3'UTR chr14:35551488(+) A-I      3'UTR chr14:35551470(+) A-I      3'UTR chr14:35551500(+) A-I      3'UTR chr14:35551443(+) A-I      3'UTR chr14:35521986(+) A-I      intronic chr14:35544122(+) A-I      intronic chr14:35522007(+) A-I      intronic chr14:35544152(+) A-I      intronic chr14:35533883(+) A-I      intronic chr14:35522085(+) A-I      intronic chr14:35523926(+) A-I      intronic chr14:35544158(+) A-I      intronic chr14:35528045(+) A-I      intronic chr14:35533067(+) A-I      intronic chr14:35544071(+) A-I      intronic chr14:35518128(+) A-I      intronic chr14:35518751(+) A-I      intronic chr14:35528057(+) A-I      intronic chr14:35539146(+) A-I      intronic chr14:35542473(+) A-I      intronic chr14:35520669(+) A-I      intronic chr14:35521882(+) A-I      intronic chr14:35535170(+) A-I      intronic chr14:35532258(+) A-I      intronic chr14:35539120(+) A-I      intronic chr14:35524876(+) A-I      intronic chr14:35532287(+) A-I      intronic chr14:35525727(+) A-I      intronic chr14:35527544(+) A-I      intronic chr14:35528393(+) A-I      intronic chr14:35537105(+) A-I      intronic chr14:35539164(+) A-I      intronic chr14:35524133(+) A-I      intronic chr14:35527848(+) A-I      intronic chr14:35518813(+) A-I      intronic chr14:35524853(+) A-I      intronic chr14:35518995(+) A-I      intronic chr14:35521997(+) A-I      intronic chr14:35518230(+) A-I      intronic chr14:35532591(+) A-I      intronic chr14:35538753(+) A-I      intronic chr14:35528010(+) A-I      intronic chr14:35535087(+) A-I      intronic chr14:35533549(+) A-I      intronic chr14:35521981(+) A-I      intronic chr14:35521875(+) A-I      intronic chr14:35516716(+) A-I      intronic chr14:35544168(+) A-I      intronic chr14:35536044(+) A-I      intronic chr14:35522053(+) A-I      intronic chr14:35535464(+) A-I      intronic chr14:35519387(+) A-I      intronic chr14:35518870(+) A-I      intronic chr14:35519420(+) A-I      intronic chr14:35541266(+) A-I      intronic chr14:35543992(+) A-I      intronic chr14:35532231(+) A-I      intronic chr14:35519450(+) A-I      intronic chr14:35522005(+) A-I      intronic chr14:35524683(+) A-I      intronic chr14:35539636(+) A-I      intronic chr14:35544132(+) A-I      intronic chr14:35535169(+) A-I      intronic chr14:35518732(+) A-I      intronic chr14:35539781(+) A-I      intronic chr14:35536056(+) A-I      intronic chr14:35521916(+) A-I      intronic chr14:35532637(+) A-I      intronic chr14:35521876(+) A-I      intronic chr14:35522103(+) A-I      intronic chr14:35535326(+) A-I      intronic chr14:35539069(+) A-I      intronic chr14:35518115(+) A-I      intronic chr14:35524237(+) A-I      intronic chr14:35527935(+) A-I      intronic chr14:35528185(+) A-I      intronic chr14:35520780(+) A-I      intronic chr14:35544123(+) A-I      intronic chr14:35539224(+) A-I      intronic chr14:35518226(+) A-I      intronic chr14:35539710(+) A-I      intronic chr14:35520744(+) A-I      intronic chr14:35533514(+) A-I      intronic chr14:35535151(+) A-I      intronic chr14:35518812(+) A-I      intronic chr14:35518728(+) A-I      intronic chr14:35533089(+) A-I      intronic chr14:35539725(+) A-I      intronic chr14:35518280(+) A-I      intronic chr14:35518360(+) A-I      intronic chr14:35539062(+) A-I      intronic chr14:35518876(+) A-I      intronic chr14:35521857(+) A-I      intronic chr14:35532664(+) A-I      intronic chr14:35521921(+) A-I      intronic chr14:35527971(+) A-I      intronic chr14:35518809(+) A-I      intronic chr14:35528338(+) A-I      intronic chr14:35518214(+) A-I      intronic chr14:35519235(+) A-I      intronic chr14:35524332(+) A-I      intronic chr14:35541228(+) A-I      intronic chr14:35535373(+) A-I      intronic chr14:35524904(+) A-I      intronic chr14:35519233(+) A-I      intronic chr14:35518201(+) A-I      intronic chr14:35519277(+) A-I      intronic chr14:35524757(+) A-I      intronic chr14:35528069(+) A-I      intronic chr14:35518941(+) A-I      intronic chr14:35521915(+) A-I      intronic chr14:35522920(+) A-I      intronic chr14:35551456(+) A-I      3'UTR chr14:35551458(+) A-I      3'UTR chr14:35551572(+) A-I      3'UTR chr14:35551465(+) A-I      3'UTR chr14:35551510(+) A-I      3'UTR chr14:35551576(+) A-I      3'UTR chr14:35551599(+) A-I      3'UTR chr14:35551668(+) A-I      3'UTR chr14:35551495(+) A-I      3'UTR chr14:35551447(+) A-I      3'UTR chr14:35551604(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM177A1	chr14:35521882(+) A-I intron -    15545495 chr14:35521921(+) A-I intron -    15545495 chr14:35521949(+) A-I intron -    15545495 chr14:35521977(+) A-I intron -    15545495 chr14:35521986(+) A-I intron -    15545495 chr14:35522021(+) A-I intron -    15545495 chr14:35522103(+) A-I intron -    15545495 chr14:35518814(+) A-G intron -    22484847 chr14:35519235(+) A-G intron -    22484847 chr14:35519450(+) A-G intron -    22484847 chr14:35544071(+) A-G intron -    22484847 chr14:35551447(+) A-G intron -    22484847 chr14:35551456(+) A-G intron -    22484847 chr14:35551458(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM177A1	chr14:35515662-35515663(+) m6A 5'UTR//intron       24284625//24981863 chr14:35515742-35515743(+) m6A CDS       24284625//24209618//24981863 chr14:35515987-35515988(+) m6A 3'UTR//intron       24981863 chr14:35516051-35516052(+) m6A 3'UTR//intron       24981863 chr14:35522453-35522454(+) m6A 5'UTR//intron       24981863 chr14:35522515-35522516(+) m6A 3'UTR//CDS       24209618//24981863 chr14:35522579-35522580(+) m6A 3'UTR//CDS       24209618//24981863//27773535 chr14:35550249-35550250(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr14:35550274-35550275(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr14:35550299-35550300(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:35550317-35550318(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:35550332-35550333(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr14:35550381-35550382(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr14:35550458-35550459(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr14:35550488-35550489(+) m6A 3'UTR       24284625//24981863//22608085 chr14:35550513-35550514(+) m6A 3'UTR       24284625//24981863 chr14:35551639-35551640(+) m6A 3'UTR//intron       - chr14:35551708-35551709(+) m6A 3'UTR//intron       - chr14:35551754-35551755(+) m6A 3'UTR//intron       - chr14:35571794-35571795(+) m6A exon//intron       27773535 chr14:35579127-35579128(+) m6A exon//intron       27773535 chr14:35579779-35579780(+) m6A 3'UTR//exon       27773535 chr14:35579815-35579816(+) m6A 3'UTR//exon       27773535 chr14:35579873-35579874(+) m6A exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM177A1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART8-3p
Interactor2: FAM177A1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.