Detail Information

Basic Information:


  VIRBase ID:  

VHID00326662

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART8-3p:           BLOC1S2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART8-3p BLOC1S2
miRBase
Accession/Entrez ID		 MIMAT0003418 282991
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BLOS2//BORCS2//CEAP//CEAP11

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BLOC1S2
chr10:102045111(-) A-I      intronic
chr10:102044706(-) A-I      intronic
chr10:102045222(-) A-I      intronic
chr10:102043585(-) A-I      intronic
chr10:102044173(-) A-I      intronic
chr10:102045157(-) A-I      intronic
chr10:102045127(-) A-I      intronic
chr10:102045072(-) A-I      intronic
chr10:102043532(-) A-I      intronic
chr10:102045306(-) A-I      intronic
chr10:102045116(-) A-I      intronic
chr10:102044187(-) A-I      intronic
chr10:102045192(-) A-I      intronic
chr10:102041228(-) A-I      intronic
chr10:102041277(-) A-I      intronic
chr10:102043556(-) A-I      intronic
chr10:102041324(-) A-I      intronic
chr10:102043507(-) A-I      intronic
chr10:102041354(-) A-I      intronic
chr10:102043632(-) A-I      intronic
chr10:102038590(-) A-I      intronic
chr10:102038608(-) A-I      intronic
chr10:102045220(-) A-I      intronic
chr10:102044417(-) A-I      intronic
chr10:102033959(-) A-I      3'UTR
chr10:102043550(-) A-I      intronic
chr10:102043510(-) A-I      intronic
chr10:102043546(-) A-I      intronic
chr10:102038805(-) A-I      intronic
chr10:102045246(-) A-I      intronic
chr10:102043598(-) A-I      intronic
chr10:102038813(-) A-I      intronic
chr10:102043440(-) A-I      intronic
chr10:102045198(-) A-I      intronic
chr10:102039324(-) A-I      intronic
chr10:102043508(-) A-I      intronic
chr10:102038732(-) A-I      intronic
chr10:102045115(-) A-I      intronic
chr10:102045044(-) A-I      intronic
chr10:102044214(-) A-I      intronic
chr10:102044810(-) A-I      intronic
chr10:102044225(-) A-I      intronic
chr10:102043465(-) A-I      intronic
chr10:102043205(-) A-I      intronic
chr10:102045183(-) A-I      intronic
chr10:102044175(-) A-I      intronic
chr10:102041260(-) A-I      intronic
chr10:102039510(-) A-I      intronic
chr10:102041353(-) A-I      intronic
chr10:102043142(-) A-I      intronic
chr10:102041329(-) A-I      intronic
chr10:102044189(-) A-I      intronic
chr10:102043206(-) A-I      intronic
chr10:102045212(-) A-I      intronic
chr10:102043200(-) A-I      intronic
chr10:102044327(-) A-I      intronic
chr10:102045256(-) A-I      intronic
chr10:102045221(-) A-I      intronic
chr10:102043462(-) A-I      intronic
chr10:102038722(-) A-I      intronic
chr10:102041235(-) A-I      intronic
chr10:102043214(-) A-I      intronic
chr10:102044388(-) A-I      intronic
chr10:102039520(-) A-I      intronic
chr10:102038792(-) A-I      intronic
chr10:102045213(-) A-I      intronic
chr10:102045124(-) A-I      intronic
chr10:102043410(-) A-I      intronic
chr10:102043569(-) A-I      intronic
chr10:102044475(-) A-I      intronic
chr10:102041274(-) A-I      intronic
chr10:102038651(-) A-I      intronic
chr10:102042921(-) A-I      intronic
chr10:102042116(-) A-I      intronic
chr10:102042107(-) A-I      intronic
chr10:102033787(-) A-I      3'UTR
chr10:102044649(-) A-I      intronic
chr10:102035818(-) A-I      intronic
chr10:102042947(-) A-I      intronic
chr10:102043049(-) A-I      intronic
chr10:102042979(-) A-I      intronic
chr10:102042962(-) A-I      intronic
chr10:102044648(-) A-I      intronic
chr10:102043014(-) A-I      intronic
chr10:102045156(-) A-I      intronic
chr10:102043043(-) A-I      intronic
chr10:102043004(-) A-I      intronic
chr10:102033792(-) A-I      3'UTR
chr10:102041846(-) A-I      intronic
chr10:102044672(-) A-I      intronic
chr10:102043549(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BLOC1S2
chr10:102042921(-) A-I intron -    22327324
chr10:102043507(-) A-I intron -    22327324
chr10:102042921(-) A-G intron -    22484847
chr10:102043043(-) A-G intron -    22484847
chr10:102043507(-) A-G intron -    22484847
chr10:102043510(-) A-G intron -    22484847
chr10:102044648(-) A-G intron -    22484847
chr10:102044649(-) A-G intron -    22484847
chr10:102044672(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BLOC1S2
chr10:102034196-102034197(-) m6A 3'UTR       27773535
chr10:102034227-102034228(-) m6A 3'UTR       27773535
chr10:102034534-102034535(-) m6A 3'UTR       27773535
chr10:102034540-102034541(-) m6A 3'UTR       27773535
chr10:102034765-102034766(-) m6A 3'UTR       27773535
chr10:102034770-102034771(-) m6A 3'UTR       27773535
chr10:102034796-102034797(-) m6A 3'UTR       27773535
chr10:102034906-102034907(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr10:102034932-102034933(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr10:102034940-102034941(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr10:102034960-102034961(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102034966-102034967(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035034-102035035(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035046-102035047(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035063-102035064(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035071-102035072(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035091-102035092(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:102035158-102035159(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:102035199-102035200(-) m6A 3'UTR       24209618//24981863//27773535//27371828//27773536//22608085
chr10:102035214-102035215(-) m6A 3'UTR       24209618//24981863//27773535//27371828//27773536//22608085
chr10:102039815-102039816(-) m6A CDS//intron       24981863//27773535//27371828//27773536//22608085
chr10:102039844-102039845(-) m6A CDS//intron       24981863//27773535//27371828//27773536//22608085
chr10:102039884-102039885(-) m6A CDS       27773535//27773536
chr10:102039977-102039978(-) m6A CDS       26404942
chr10:102040698-102040699(-) m6A CDS//exon       26404942
chr10:102040704-102040705(-) m6A CDS//exon       24981863//26404942
chr10:102040713-102040714(-) m6A CDS//exon       24981863//26404942
chr10:102040725-102040726(-) m6A CDS//exon       24981863//26404942
chr10:102040769-102040770(-) m6A CDS//exon       24981863//26404942
chr10:102040797-102040798(-) m6A CDS//exon       24981863//26404942//27371828
chr10:102045860-102045861(-) m6A CDS//exon       24981863//26404942//27371828
chr10:102045897-102045898(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828
chr10:102045952-102045953(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535//27371828
chr10:102045996-102045997(-) m6A 5'UTR//exon//intron       24209618//24981863//27773535//27371828//22608085
chr10:102046036-102046037(-) m6A 5'UTR//exon//intron       24209618//25456834//24981863//27773535//27371828//22608085
chr10:102046105-102046106(-) m6A 5'UTR//intron       24209618//25456834//24981863//27773535//27371828
chr10:102046432-102046433(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BLOC1S2
Chromatin K562 cells     -
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART8-3p
Interactor2: BLOC1S2

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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