Detail Information

Basic Information:


  VIRBase ID:  

VHID00325846

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART8-3p:           RFX7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART8-3p RFX7
miRBase
Accession/Entrez ID		 MIMAT0003418 64864
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - RFXDC2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RFX7
chr15:56479546(-) A-I      intronic
chr15:56449966(-) A-I      intronic
chr15:56408028(-) A-I      intronic
chr15:56407980(-) A-I      intronic
chr15:56450974(-) A-I      intronic
chr15:56407955(-) A-I      intronic
chr15:56407902(-) A-I      intronic
chr15:56407437(-) A-I      intronic
chr15:56450994(-) A-I      intronic
chr15:56459007(-) A-I      intronic
chr15:56496377(-) A-I      intronic
chr15:56407392(-) A-I      intronic
chr15:56407383(-) A-I      intronic
chr15:56407380(-) A-I      intronic
chr15:56459072(-) A-I      intronic
chr15:56479501(-) A-I      intronic
chr15:56407346(-) A-I      intronic
chr15:56407340(-) A-I      intronic
chr15:56406528(-) A-I      intronic
chr15:56406527(-) A-I      intronic
chr15:56406497(-) A-I      intronic
chr15:56406348(-) A-I      intronic
chr15:56399438(-) A-I      intronic
chr15:56399383(-) A-I      intronic
chr15:56399382(-) A-I      intronic
chr15:56399306(-) A-I      intronic
chr15:56481236(-) A-I      intronic
chr15:56481417(-) A-I      intronic
chr15:56441075(-) A-I      intronic
chr15:56481419(-) A-I      intronic
chr15:56481572(-) A-I      intronic
chr15:56476440(-) A-I      intronic
chr15:56406496(-) A-I      intronic
chr15:56491101(-) A-I      intronic
chr15:56491167(-) A-I      intronic
chr15:56492769(-) A-I      intronic
chr15:56407405(-) A-I      intronic
chr15:56492825(-) A-I      intronic
chr15:56492840(-) A-I      intronic
chr15:56492964(-) A-I      intronic
chr15:56494743(-) A-I      intronic
chr15:56494886(-) A-I      intronic
chr15:56496218(-) A-I      intronic
chr15:56496454(-) A-I      intronic
chr15:56496489(-) A-I      intronic
chr15:56521658(-) A-I      intronic
chr15:56521669(-) A-I      intronic
chr15:56521684(-) A-I      intronic
chr15:56521692(-) A-I      intronic
chr15:56521709(-) A-I      intronic
chr15:56406487(-) A-I      intronic
chr15:56494888(-) A-I      intronic
chr15:56408093(-) A-I      intronic
chr15:56450896(-) A-I      intronic
chr15:56408040(-) A-I      intronic
chr15:56406595(-) A-I      intronic
chr15:56481159(-) A-I      intronic
chr15:56481416(-) A-I      intronic
chr15:56481127(-) A-I      intronic
chr15:56476516(-) A-I      intronic
chr15:56481367(-) A-I      intronic
chr15:56449926(-) A-I      intronic
chr15:56408016(-) A-I      intronic
chr15:56441045(-) A-I      intronic
chr15:56441159(-) A-I      intronic
chr15:56441197(-) A-I      intronic
chr15:56449916(-) A-I      intronic
chr15:56441090(-) A-I      intronic
chr15:56459044(-) A-I      intronic
chr15:56481364(-) A-I      intronic
chr15:56449915(-) A-I      intronic
chr15:56450898(-) A-I      intronic
chr15:56476387(-) A-I      intronic
chr15:56527383(-) A-I      intronic
chr15:56407275(-) A-I      intronic
chr15:56494885(-) A-I      intronic
chr15:56510534(-) A-I      intronic
chr15:56523113(-) A-I      intronic
chr15:56411201(-) A-I      intronic
chr15:56408023(-) A-I      intronic
chr15:56407406(-) A-I      intronic
chr15:56421317(-) A-I      intronic
chr15:56433561(-) A-I      intronic
chr15:56494958(-) A-I      intronic
chr15:56494847(-) A-I      intronic
chr15:56441157(-) A-I      intronic
chr15:56451010(-) A-I      intronic
chr15:56496294(-) A-I      intronic
chr15:56476314(-) A-I      intronic
chr15:56450959(-) A-I      intronic
chr15:56496355(-) A-I      intronic
chr15:56449918(-) A-I      intronic
chr15:56523103(-) A-I      intronic
chr15:56459459(-) A-I      intronic
chr15:56479511(-) A-I      intronic
chr15:56494927(-) A-I      intronic
chr15:56407348(-) A-I      intronic
chr15:56510533(-) A-I      intronic
chr15:56523174(-) A-I      intronic
chr15:56473124(-) A-I      intronic
chr15:56521683(-) A-I      intronic
chr15:56450912(-) A-I      intronic
chr15:56450888(-) A-I      intronic
chr15:56496235(-) A-I      intronic
chr15:56481128(-) A-I      intronic
chr15:56407345(-) A-I      intronic
chr15:56408018(-) A-I      intronic
chr15:56481575(-) A-I      intronic
chr15:56523184(-) A-I      intronic
chr15:56407932(-) A-I      intronic
chr15:56521668(-) A-I      intronic
chr15:56481173(-) A-I      intronic
chr15:56407947(-) A-I      intronic
chr15:56421315(-) A-I      intronic
chr15:56476509(-) A-I      intronic
chr15:56439976(-) A-I      intronic
chr15:56494799(-) A-I      intronic
chr15:56494923(-) A-I      intronic
chr15:56439977(-) A-I      intronic
chr15:56407483(-) A-I      intronic
chr15:56509143(-) A-I      intronic
chr15:56407482(-) A-I      intronic
chr15:56481521(-) A-I      intronic
chr15:56510505(-) A-I      intronic
chr15:56423558(-) A-I      intronic
chr15:56408102(-) A-I      intronic
chr15:56441234(-) A-I      intronic
chr15:56411211(-) A-I      intronic
chr15:56496297(-) A-I      intronic
chr15:56481516(-) A-I      intronic
chr15:56496420(-) A-I      intronic
chr15:56421473(-) A-I      intronic
chr15:56481537(-) A-I      intronic
chr15:56450911(-) A-I      intronic
chr15:56407276(-) A-I      intronic
chr15:56494767(-) A-I      intronic
chr15:56439939(-) A-I      intronic
chr15:56421382(-) A-I      intronic
chr15:56472911(-) A-I      intronic
chr15:56494928(-) A-I      intronic
chr15:56408096(-) A-I      intronic
chr15:56496512(-) A-I      intronic
chr15:56441115(-) A-I      intronic
chr15:56481413(-) A-I      intronic
chr15:56496483(-) A-I      intronic
chr15:56407336(-) A-I      intronic
chr15:56521666(-) A-I      intronic
chr15:56523125(-) A-I      intronic
chr15:56496425(-) A-I      intronic
chr15:56406352(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RFX7
chr15:56496235(-) A-I intron -    15342557
chr15:56496294(-) A-I intron -    15342557
chr15:56496355(-) A-I intron -    15342557
chr15:56496377(-) A-I intron -    15342557
chr15:56496425(-) A-I intron -    15342557
chr15:56496483(-) A-I intron -    15342557
chr15:56496512(-) A-I intron -    15342557
chr15:56525648(-) G-A intron -    22484847
chr15:56451010(-) A-G intron -    22484847
chr15:56465956(-) T-C intron -    22484847
chr15:56481413(-) A-G intron -    22484847
chr15:56509143(-) A-G intron -    22484847
chr15:56523103(-) A-G intron -    22484847
chr15:56531310(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RFX7
chr15:56379623-56379624(-) m6A 3'UTR       25456834//27773535//22608085
chr15:56379637-56379638(-) m6A 3'UTR       25456834//27773535//22608085
chr15:56379656-56379657(-) m6A 3'UTR       25456834//27773535//22608085
chr15:56380150-56380151(-) m6A 3'UTR       27773535
chr15:56382734-56382735(-) m6A 3'UTR//intron       27773535
chr15:56382748-56382749(-) m6A 3'UTR//intron       27773535
chr15:56382758-56382759(-) m6A 3'UTR//intron       27773535
chr15:56382844-56382845(-) m6A 3'UTR//intron       27773535
chr15:56382922-56382923(-) m6A 3'UTR//intron       27773535
chr15:56383019-56383020(-) m6A 3'UTR//intron       24981863
chr15:56383072-56383073(-) m6A 3'UTR//intron       24981863
chr15:56384471-56384472(-) m6A 3'UTR//intron       27773535
chr15:56384481-56384482(-) m6A 3'UTR//intron       27773535
chr15:56384505-56384506(-) m6A 3'UTR//intron       27773535
chr15:56384804-56384805(-) m6A 3'UTR//intron       27773535
chr15:56384902-56384903(-) m6A 3'UTR//intron       27773535
chr15:56385504-56385505(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr15:56385570-56385571(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr15:56385686-56385687(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56385723-56385724(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56385732-56385733(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56385844-56385845(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56385855-56385856(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56385870-56385871(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56385988-56385989(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr15:56386061-56386062(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr15:56386113-56386114(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56386157-56386158(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr15:56386191-56386192(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr15:56386225-56386226(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr15:56386465-56386466(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr15:56386508-56386509(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr15:56386589-56386590(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:56386613-56386614(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:56386637-56386638(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:56386650-56386651(-) m6A CDS       24284625//24981863//22575960//22608085
chr15:56386661-56386662(-) m6A CDS       24284625//24981863//22575960//22608085
chr15:56386747-56386748(-) m6A CDS       24284625//27773535//22608085
chr15:56386772-56386773(-) m6A CDS       24284625//27773535
chr15:56386784-56386785(-) m6A CDS       24284625//27773535
chr15:56386966-56386967(-) m6A CDS       24284625//24209618//24981863//27773535//27371828
chr15:56387223-56387224(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr15:56387282-56387283(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr15:56387314-56387315(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr15:56387345-56387346(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr15:56387439-56387440(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr15:56387534-56387535(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:56387622-56387623(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr15:56387648-56387649(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr15:56387683-56387684(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:56387690-56387691(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:56387812-56387813(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:56387838-56387839(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:56387858-56387859(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:56387891-56387892(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr15:56387903-56387904(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr15:56387926-56387927(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr15:56387982-56387983(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:56388036-56388037(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr15:56388127-56388128(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:56388182-56388183(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr15:56388235-56388236(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr15:56388261-56388262(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:56388298-56388299(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:56388305-56388306(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:56388331-56388332(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:56388424-56388425(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:56388455-56388456(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:56388550-56388551(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22608085
chr15:56388612-56388613(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr15:56388620-56388621(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr15:56388694-56388695(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr15:56388707-56388708(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr15:56388808-56388809(-) m6A CDS       24284625//24981863//27773535//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate RFX7
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART8-3p
Interactor2: RFX7

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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